I use 23g on every site, some are way less comfortable than others. I go nice and slow, .25ml then wait 5 long seconds then another .25 then wait and repeat too it's all in.
That's something about a 21g that I really don't like. A lot of oil or water could be dumped into the muscle at a rapid rate. Something I think would also be something to consider with pain. I use a 25g to ensure a slow and steady pace.