Is this the right stack for my goals?

[hammerheart]

It seems weird to me, too.

What I do know is I was diagnosed with Hashimotos at 23, 21-hydroxylase deficiency (and resulting elevated testosterone) around age 33-34, and then primary ovarian failure at age 41. Other than this and being pretty friggin overweight, I'm healthy. No diabetes, no insulin resistance, no hypertension, great cholesterol, lowish resting heart rate.

No doctor said it was related to Hashimotos. And the endo who diagnosed the 21-hydroxylase deficiency didn't about CAH or do further testing.

But, given the hypothalamic-pituitary-thyroidal axis I just sort of thought it couldn't be a coincidence. When looking up studies on PubMed I can't find one that examined this axis dysfunction or function in Hashimotos.

I didn't start having serious problem with my metabolism impacting my QOL until I went through early meno.

Thanks four replying!

Noted.

No idea what your endo was thinking when diagnosing without testing, that's above my comprehension.

BTW, deficiences in adrenal hyperplasias are on a spectrum - enzyme activity, despite being lower than normal might still be enough to preserve some functioning, so each patient will have his own presentation and severity of symptoms. If your cortisol is normal and there aren't systemic, classical manifestations of the disease like hypotension, electrolyte disturbances and the sort then my guess is you can do fine without the standard treatment (other than HRT), that is, glucocorticoids (usually dexamethasone) to suppress ACTH. Your Testosterone will still be high but if that isn't giving you any issue then it's only a bonus, imo.

[friedbank]

Noted.

No idea what your endo was thinking when diagnosing without testing, that's above my comprehension.

BTW, deficiences in adrenal hyperplasias are on a spectrum - enzyme activity, despite being lower than normal might still be enough to preserve some functioning, so each patient will have his own presentation and severity of symptoms. If your cortisol is normal and there aren't systemic, classical manifestations of the disease like hypotension, electrolyte disturbances and the sort then my guess is you can do fine without the standard treatment (other than HRT), that is, glucocorticoids (usually dexamethasone) to suppress ACTH. Your Testosterone will still be high but if that isn't giving you any issue then it's only a bonus, imo.

Honestly, I've not had good success finding an endo willing to actually treat me for anything other than the hypothyroidism. Its extremely frustrating.

My cortisol is normal, I'm not hypotensive or ever ran than way.

Right now the only Rxed HRT I'm on is the Armour, which works way better for me than the synthetics. My endo won't Rx anything else. "You're post meno, this is what happens, you'll get used to it". I worry doctor shopping will throw up red flags with insurance, etc.

And, yes, my ACTH is through the roof.

Obviously I'm here because my QOL is in the gutter.