TRT - Without HCG

[macmathews]

They work by very different mechanisms.

HCG is a protein hormone that binds to both LH and FSH receptors to mimic the missing gonadotropins LH and FSG.

Nolvadex (tamoxifen citrate) is a Selective Estrogen Receptor Modulator (SERM) that binds to estrogen receptors but has little estrogenic activity. This prevents E2 from binding and exerting its affect. Tamoxifen has mostly peripheral activity but does bind to hypothalamic receptors too, so yes, it may have a benefit similar to Clomid in stimulating the release of GnRH and thus, LH and FSH.

Clomid, is also a SERM but it is more selective to the hypothalamus.

The reason SERMs have not become popular as a replacement for HCG in maintaining testicular size and function is that they also have some mild estrogenic side-effects. In my experiments with Clomid, I found that the side-effects were tolerable up to a dose of about 12.5 mg (1/4 tablet) daily. I also noticed (subjectively) that there was minimal loss of testicular size over the approximate 6 week test period. At doses higher than 12.5 mg daily, I noticed some Central Nervous System side-effects similar to High E/Low T symptoms (mood, libido, energy, etc.).

What did you noticed Libido wise ?
I once tried clomid 25mg EOD for a period of 4 months or so.. It raised my Libido even slightly more than just Test injections.
And even got my total T fairly high but since it raised my SHBG so much my free T was barely in Range.

[Youthful55guy]

What did you noticed Libido wise ?
I once tried clomid 25mg EOD for a period of 4 months or so.. It raised my Libido even slightly more than just Test injections.
And even got my total T fairly high but since it raised my SHBG so much my free T was barely in Range.

Just the opposite with me. Libido and ED issues were part of the estrogenic effects that I referred to as negative side-effects of clomid for me. At 12.5 mg daily, it was tolerable, but definitely not enhanced like with TRT.