Estrogen hinder gains

[Obs]

I already did

Regarding estrogen competing with free testosterone,
https://forums.steroid.com/before-yo...ould-know.html

But on nolva? Does the same occour? I know you mentioned it before

[cousinmuscles]

But on nolva? Does the same occour? I know you mentioned it before

I mentioned nolva lowering IGF1. So a small increase in IGF1 from higher estrogen is negated by nolva since it lowers IGF1. Aha, you want a source, of course, think I just pull this stuff out of my ass, lol... https://www.ncbi.nlm.nih.gov/pubmed/1421427 https://www.ncbi.nlm.nih.gov/pubmed/11299809 Since it acts as an antiestrogen on the liver, where IGF1 is produced, it inhibits the production of it.

[Obs]

I mentioned nolva lowering IGF1. So a small increase in IGF1 from higher estrogen is negated by nolva since it lowers IGF1. Aha, you want a source, of course, think I just pull this stuff out of my ass, lol... https://www.ncbi.nlm.nih.gov/pubmed/1421427 https://www.ncbi.nlm.nih.gov/pubmed/11299809 Since it acts as an antiestrogen on the liver, where IGF1 is produced, it inhibits the production of it.

No I trusted what you said before. I phrased my question improperly.

I mean if you are on nolva during cycle does estrogen still compete for testosterone receptors?

[cousinmuscles]

No I trusted what you said before. I phrased my question improperly.

I mean if you are on nolva during cycle does estrogen still compete for testosterone receptors?

Well nolvadex doesn't lower serum estrogen, meaning all the estrogen in your blood. It just blocks estrogen receptors in some tissues. There is nothing saying it does anything to the androgen receptor either. So whatever estrogen does on the androgen receptor it will do when nolvadex is used too.

Haven't read how much (to which degree) estrogen negates free testosterone, nor any real comparisons using an AI/no AI with test cycles... I don't get gyno but wouldn't even try a full cycle.

[cousinmuscles]

Well nolvadex doesn't lower serum estrogen, meaning all the estrogen in your blood. It just blocks estrogen receptors in some tissues. There is nothing saying it does anything to the androgen receptor either. So whatever estrogen does on the androgen receptor it will do when nolvadex is used too.

Haven't read how much (to which degree) estrogen negates free testosterone, nor any real comparisons using an AI/no AI with test cycles... I don't get gyno but wouldn't even try a full cycle.

Correction: I don't know about that. It seems it does in some tissue like in the prostate.