Anti psychotics and increased prolactin.

[edmundo22]

Hey Socio.
you know your stuff, my diagnosis is major depression and paranoid psychosis, I got both from getting addicted to huffing leaded gasoline as a kid. Iv ran through a bunch of anti psych meds over the past 10 years none have really helped, it's only cuz I suggested clozapine to my doc that there finally putting me on it, it's meant to be the best and most effective, I can deal with drooling at night, feeling drowsy but don't want fatigue / lack of strength. Iv read clozapine works differently from all the rest in that it doesn't affect dopamine receptors which I think is the cause of increased prolactin, I'm also looking into nuerogenic drugs to heal whatever damage I have in my brain, currently taking NSI 189 and looking into ISRIB next, I workout mostly cause it helps depression just don't want to be held back due to psych meds hindering my progress.

My doc says it does increase prolactin, it could be minimal but I can't find anything online that gives exact figures, what's metabolic syndrome?, getting fat?

[SocioMachiavelli]

Hey Socio.
you know your stuff, my diagnosis is major depression and paranoid psychosis, I got both from getting addicted to huffing leaded gasoline as a kid. Iv ran through a bunch of anti psych meds over the past 10 years none have really helped, it's only cuz I suggested clozapine to my doc that there finally putting me on it, it's meant to be the best and most effective, I can deal with drooling at night, feeling drowsy but don't want fatigue / lack of strength. Iv read clozapine works differently from all the rest in that it doesn't affect dopamine receptors which I think is the cause of increased prolactin, I'm also looking into nuerogenic drugs to heal whatever damage I have in my brain, currently taking NSI 189 and looking into ISRIB next, I workout mostly cause it helps depression just don't want to be held back due to psych meds hindering my progress.

My doc says it does increase prolactin, it could be minimal but I can't find anything online that gives exact figures, what's metabolic syndrome?, getting fat?

Cardiovascular exercise can cause neurogenesis, to combat the depression running would be better than lifting.... but both would be best.

What are you like when you are off of your meds? I'm sure that you are aware that you have to be slowly titrated onto the clozapine and you should be having both pre and post clozapine observations.... This consists of BP/Heart rate/temp/resp rate etc. I am interested how this will be facilitated outside of a hospital, Unless I am mistaken and you are in one. You will also require routine blood tests to check for agranulocytosis, also if you are smoker this can inhibit the concentration levels of the drug in your system... So if you do smoke and decide to stop talk to the doc first.

Clozapine can be incredibly effective at treating resistant psychotic symptoms, however on average men with schizophrenia die on average 18.6 years younger than those without it... A lot of this is down to lifestyle choice but also due to iatrogenic illness (illness caused by the psych meds). If you could find a way of making it work without the clozapine I would definitely do that, I appreciate you have spent ten years trying to find the right meds... but I'd advise keep looking and take up running.

You can also be prescribed procyclidine to combat the extra pyramidal side effects such as excess salivation etc