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Thread: Anti psychotics and increased prolactin.

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  1. #1
    Join Date
    Jul 2009
    Location
    Europe
    Posts
    1,561
    There's something I don't understand here.

    The main medication to reduce prolactin is Dostinex (sold as Cabergoline). Dostinex works as a dopamine agonist (if I understand correctly), just like the modern so-called antipsychotics do (e.g. olanzapine, risperidone). The difference is that dostinex doesn't have a mental effect because it doesn't cross the blood-brain barrier.

    So if dostinex reduces prolactin, and if major tranquilisers like olanzapine do the same thing, then I would expect seroquel to decrease prolactin.

    I'm not a doc or anything but I'm surprised your prolactin is up instead of down.

  2. #2
    Join Date
    Jan 2018
    Posts
    306
    The only dopaminergetic system stabilizing medication is aripiprazole, it makes to produce more dopamine if you are deficient and also blocks dopamine release if you have it too much. Like I said it's very often prescribed in combination with neuroleptic medications like risperidone, haloperidol and olanzapine, to protect from a complete dopamine realise blockade and also positively improves prolactin - dopamine ratio. Well if your doc is against prescribing it there is also dopamine agonist medication called bromocriptine, I think you will not need to add more than 2.5 mg to restore prolactin in normal range.

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