DNP stuff

[GearHeaded]

DNP !!!! what are you crazy, you can't talk about that type of stuff publicly!!
kidding.


below is a brief post I did on another thread that will perhaps bring a tad bit of insight
----

its interesting , the two most dangerous drugs in bodybuilding go very well stacked together , DNP with Insulin

DNP makes you more insulin sensitive , BUT it also stops your body from producing insulin (I'll explain below), so its a catch 22 really. But if you take insulin with DNP then you get the best of both worlds. You get to burn body fat, utilize a shit ton of carbs without being able to put on more body fat, and build muscle .

If exogenous insulin and high amounts of carbs make you fat, then just add DNP. If DNP makes you flat and have high blood sugars cause your body is no longer able to produce insulin from it , then just add insulin. If your worried about losing muscle on a cut with DNP, just add insulin. With insulin present you'll still be able to uptake glucose, amino acids, and other nutrients into muscle cells (that anabolism) , its just that your cell will no longer be able to use that glucose as energy , but you still get the anabolic effect . Running DNP without insulin and you won''t get that effect.
so to a certain degree they are synergistic together.

DNP essentially turns you temporarily into a type 1 diabetic (not able to produce insulin from the pancreas). thats why adding insulin is beneficial when using it. I'll explain

Insulin is released by pancreatic beta cells in response to elevated ATP/ADP ratios . Briefly, when your blood sugar levels rise, your ATP/ADP levels become elevated, inhibiting ATP sensitive potassium ion channels (KATP), altering the membrane potential of the pancreatic cells and causing insulin release. The main thing here is that insulin will not be released unless ATP levels within the cells increase. DNP interferes with the protein complex ATP synthase, which allows for the synthesis of ATP from ADP . Since DNP interferes with a key step in ATP production, obviously ATP levels never elevate within any cell, including pancreatic beta cells. Hence , the feedback system through the KATP channels (at least in regards to insulin release), is disabled, and you effectively make yourself a diabetic while on DNP.

The primary action of insulin in the body is to drive glucose into muscle and liver cells (stored as glycogen) which is converted into ATP. Since DNP reduces ATP production significantly*, it again interferes with insulin production by preventing a significant amount of the glucose that is pushed into cells by insulin from ever being used as energy (at least by the cell). So , what is happening to all of this energy that is being expended through the electron transport chain to turn ADP and Pi into ATP? It’s thrown off as heat, and lots of it . thats the main side effect of DNP, as well as the cause of death if you over dose (over heating from the inside)

*DNP is an uncoupling agent. Stopping ATP is what its designed to do. Fat oxidation becomes the bodies source of energy, and why DNP burns body fat so well


so HoldMyBeer, you can see also why if you run high carb diet while on DNP yet without running insulin, that all those carbs do is get burned up as body heat

[HoldMyBeer]

DNP !!!! what are you crazy, you can't talk about that type of stuff publicly!!
kidding.


below is a brief post I did on another thread that will perhaps bring a tad bit of insight
----

its interesting , the two most dangerous drugs in bodybuilding go very well stacked together , DNP with Insulin

DNP makes you more insulin sensitive , BUT it also stops your body from producing insulin (I'll explain below), so its a catch 22 really. But if you take insulin with DNP then you get the best of both worlds. You get to burn body fat, utilize a shit ton of carbs without being able to put on more body fat, and build muscle .

If exogenous insulin and high amounts of carbs make you fat, then just add DNP. If DNP makes you flat and have high blood sugars cause your body is no longer able to produce insulin from it , then just add insulin. If your worried about losing muscle on a cut with DNP, just add insulin. With insulin present you'll still be able to uptake glucose, amino acids, and other nutrients into muscle cells (that anabolism) , its just that your cell will no longer be able to use that glucose as energy , but you still get the anabolic effect . Running DNP without insulin and you won''t get that effect.
so to a certain degree they are synergistic together.

DNP essentially turns you temporarily into a type 1 diabetic (not able to produce insulin from the pancreas). thats why adding insulin is beneficial when using it. I'll explain

Insulin is released by pancreatic beta cells in response to elevated ATP/ADP ratios . Briefly, when your blood sugar levels rise, your ATP/ADP levels become elevated, inhibiting ATP sensitive potassium ion channels (KATP), altering the membrane potential of the pancreatic cells and causing insulin release. The main thing here is that insulin will not be released unless ATP levels within the cells increase. DNP interferes with the protein complex ATP synthase, which allows for the synthesis of ATP from ADP . Since DNP interferes with a key step in ATP production, obviously ATP levels never elevate within any cell, including pancreatic beta cells. Hence , the feedback system through the KATP channels (at least in regards to insulin release), is disabled, and you effectively make yourself a diabetic while on DNP.

The primary action of insulin in the body is to drive glucose into muscle and liver cells (stored as glycogen) which is converted into ATP. Since DNP reduces ATP production significantly*, it again interferes with insulin production by preventing a significant amount of the glucose that is pushed into cells by insulin from ever being used as energy (at least by the cell). So , what is happening to all of this energy that is being expended through the electron transport chain to turn ADP and Pi into ATP? It’s thrown off as heat, and lots of it . thats the main side effect of DNP, as well as the cause of death if you over dose (over heating from the inside)

*DNP is an uncoupling agent. Stopping ATP is what its designed to do. Fat oxidation becomes the bodies source of energy, and why DNP burns body fat so well


so HoldMyBeer, you can see also why if you run high carb diet while on DNP yet without running insulin, that all those carbs do is get burned up as body heat

Whats the protocol for the insulin? Do I stay on a cal deficit?

[GearHeaded]

Whats the protocol for the insulin? Do I stay on a cal deficit?

while on DNP your natty production of insulin is shut down. the simplest protocol is to try and mimic what endogenous insulin production would be. thats best accomplished with something like a Lantus insulin. you could start out at like 10iu per day. you'll keep your diet low carb and stay in a calorie deficit.
you won't get the muscular fullness that you would with other insulin protocols. but this is a safe basic protocol at an 'insulin replacement dose' sort of speak.

another way is to use a regular acting insulin protocol with your meals. and yes you'd still stay in a calorie deficit. you could start out with 5iu with three of your meals per day.

theres really a lot of ways to do it . depends on many factors and your current physique and insulin sensitivity and a host of other things..

FIRST things first though. I'd go buy a 10$ glucose meter at Walmart and start tracking your blood sugars and get a baseline fasted glucose track going.
start with the glucose meter and go from there, rather then start any other protocols at the exact moment. you need a baseline in which to build a proper protocol around.


NOTE- I'm a advocate for low dose DNP use 'over time'. 200-300mg should get the job done over the period of your cutting phase, e.g, 12 weeks. I don't believe in mega dosing DNP for short term fat loss. so NO I don't recommend you raise the dose.
I'd rather see a well put together and thought out 12+ week long cutting protocol established with diet strategies ready to be implemented.

high dose DNP use is very un-neccessary and as you well know very very dangerous