I think it’s two fold. I’m parroting here so take this with a grain of salt. Like to give that caveat. From what I understand, the diphenhydramine down regulates beta receptors keeping the tolerance to clen from increasing. Benadryl slows desensitization of Beta receptors, so there is essentially a synergistic effect. The additional benefit is the anxiety and insomnia that comes with Clen and the diphenhydramine is also useful in circumventing those two sides.





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