
Originally Posted by
powerliftmike
Anadrol is one of the best, especially in strength sports. Anadrol has about double the half life of dianabol so does not require such frequent dosing. Twice per day should suffice. Regarding hepatoxicity, that is the nature of the recommendation to use sporadically (as the liver is both robust and regenerative); let us not forget however that part of the basis of the recommendation is not solely AST/ALT enzymes, bile, and liver stress, but the detrimental effect on HDL and hypercholesterolemia. Long term status of this can greatly effect endothelial tissue and thus raise the risk of heart disease. Of course this is a classic AAS to raise blood pressure by different routes and long term hypertension destroys the kidneys in particular.
This leads into the trenbolone advisories: tren is actually pretty toxic to the body in general. In fact, as far as I am aware it is the only AAS that has shown to be toxic to the brain (i.e. "17β-trenbolone induces apoptosis of primary hippocampal neurons" [Ma & Liu, 2015]). Testosterone is actually protective of neurological tissue. Tren can cause significant hypertension and lead to the aforemented heart disease and kidney disease risks.
Ma, F. & Liu, D. (2015) 17β-trenbolone, an anabolic–androgenic steroid as well as an environmental hormone, contributes to neurodegeneration. Toxicology and Applied Pharmacology, 282, 1; pgs 68-76.