
Originally Posted by
Youthful55guy
I'll try. It is a somewhat complicated subject.
Guys who have low SHBG burn through T much faster than guys with normal or high SHBG. For a couple days after the injection, their Free T skyrockets and that drives Red blood cell (RBC) production. Hemoglobin and hematocrit are 2 ways to measure RBC production. Both T and DHT (to a grater extent) will push up your RBC production, so the more free T that is available, the more RBCs you produce.
The problem is that you burn through T so quickly, that with standard doses (e.g., 100mg in once weekly injections), you do not have a sufficient amount of T left in you system at the end of the week, so you feel like crap. To compensate (if you stick with once weekly injections), you inject larger and lager amounts of T so that you have something left at the end of the week to feel somewhat normal. However, this pushes your post-injection spike in blood T levels higher and high, and this drives RBC production faster and faster. Sometimes to dangerous levels.
Again, I have the opposite problem with SHBG, so I can only go off of what I've heard other guys discuss in various forums. The consensus among these guys is that when you have low SHBG, you are better off with more frequent injections of T rather than increasing the dose. So, for example, instead of bumping the weekly dose up to 200mg, you might consider injecting 20mg per day which equates to 140mg/week. This will help keep your Free T levels in the normal range throughout the week without driving huge spikes in Free T as you would with a larger 200mg once weekly dose. This will slow down RBC product to a more normal rate.