I've been meaning to share this information with you all for a couple weeks now, but i've been pretty busy with the holidays and what not.
Anyhow, my personal research as well as my university studies have lead me to some interesting information on Anavar and its effects on HPTA suppression, and the real hard truth behind it. Anavar has always been touted as a very 'mild' compound. For the most part, it is. But too many people have for decades been using the world 'mild' to describe every effect and aspect of this compound. Anavar is NOT 'mild' in the realm of HPTA function, nor is it 'mild' in terms of its anabolic effects (it is actually quite the powerful anabolic steroid, perhaps more so than Anadrol in fact), however that's a story for another day. The focus of my quick post here is Anavar's effects on the HPTA since that is one of the most expounded descriptions of one of the areas Anavar is frequently said to be 'mild' in. Well, i'm here to tell you all that this is absolutely not the case. Anavar is just as suppressive as any anabolic steroid out there in existance.
In my program, shortly before the Christmas break, we actually covered Anavar!!! I was extremely excited (and surprised) to see that here in a pre-med university program, we're actually covering (albeit very briefly) an anabolic steroid and its effects on the endocrine system. As anyone familiar with life-sciences programs and med school programs knows, there is no such thing as an 'anabolic steroid' course or class. So I was pretty ecstatic, even though this was very brief. We covered some of its actions in muscle tissue and other tissues, we covered its medical applications and its beneficial results in patients suffering from trauma and its use as an osteoperosis medication. A guest speaker covered most of this with us, who is a former proffessor and is a current MD involved in research in the Division of Endocrinology and Metabolism. After everything was over, I had a chance to speak to him and ask him to share/exchange information concerning Anavar and such. Of course the guy is very busy and had only a half hour to spare with me, which I thought was very generous of him. So we discussed a whole ton of AAS-related topics, of which 30 minutes was just not enough time, and man was I blown away. But where Anavar is concerned, he told me quite a few eye-opening details, and provided me with a bunch of clinical studies to investigate for my own personal amusement.
It seems as though Anavar is commonly labelled by all of the gym bros for decades as 'mildly' suppressive to the HPTA, but there is only a sliver of truth to this. This seems to only be the case with the absolute lowest of medical prescription doses (such as 5mg daily administered to children). Bodybuilding doses, which is what we are all concerned with here, is a whole different ball game and in studies demonstrate very strong suppression of endogenous Testosterone production. The most prominent study I saw was one involving 6 young male test subjects that were administered Anavar had shown that after only 5 days of Anavar administration (at only 15mg/day), the Testosterone levels ofthese 6 subjects dropped DRASTICALLY by day 5 from 449ng/dl to 282ng/dl – a 37% reduction of Testosterone in just 5 days(1). That is a massive drop after such a small period of time at a dose that isn't even considered a 'bodybuilding' dose. If this is what Anavar does at 15mg daily after 5 days of use, ask yourself what bodybuilding doses (30mg MINIMUM daily of Anavar) for weeks will end up doing?
This is a graph from the study conducted. It demonstrates total androgen concentration showing total serum Testosterone (lined areas) and Oxandrolone (black areas) concentrations in five young men on days 0, 3, and 5, Testosterone decreased significantly from days 0 and 3 to day 5 (P < 0.05).
- The first point i'm making of this post is to show all of you newcomers and youngsters here who are under the age of 24 that Anavar is NOT a safe or 'mild' choice to engage in. It very well has the potential for the same amount of shutdown as a Testosterone cycle as far as I am concerned. So if you think that attempting an Anavar-only cycle for your first cycle is going to save you from any potential permanent HPTA problems later on in life, think again!
- The second point i'm making here is to show that Anavar-only cycles are destructive to the body without the inclusion of some form of Testosterone. Anavar necessitates the use of Testosterone in at least a TRT dose in order to maintain normal physiological function in the presence of a suppressed/shutdown HPTA as a result of Anavar use. Will you die if you do an Anavar-only cycle? No. But it's not optimal or healthy for the body, and can cause issues (both noticeable and un-noticeable) when your endogenous production of Testosterone bottoms out.
There exists no 'perfect anabolic steroid', but Anavar is perhaps the anabolic steroid that has come the closest to the 'perfect steroid' - but the point here it that is NOT 'perfect' by any means and still possesses its flaws.
REFERENCES:
1. Short-Term Oxandrolone Administration Stimulates Net Muscle Protein Synthesis in Young Men. Melinda Sheffield-Moore, Randall J. Urban, Steven E. Wolf, J. Jiang, Don H. Catlin, David N. Herndon, Robert R. Wolfe and Arny A. Ferrando. Sheffield-Moore et al. Journal of Clinical Endocrinology & Metabolism. August 1, 1999; 84 (8): 2705
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Originally Posted by kelkel
