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  1. #1
    JoCk4LiFe58 is offline New Member
    Join Date
    Jan 2005

    CLeNbUtErOL SaFe Or NoT?

    I have a gland disorder and have a very slow metobolism and cannot lose the weight I want, I am currently about to begin a cycle are there any thoughts on Clen anyone can give me oh its side effects and dosages?? Mainly on the heart?

  2. #2
    Front Runner is offline New Member
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    Jan 2005


    J Appl Physiol. 2004 Dec 10; [Epub ahead of print] Related Articles, Links

    {beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.

    Burniston JG, Tan LB, Goldspink DF.

    Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

    High doses of the beta2-adrenergic receptor (AR) agonist, clenbuterol , can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known if this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections of clenbuterol. Immunohistochemistry was used to detect myocyte specific apoptosis (detected on cryosections using a caspase 3 antibody and confirmed using annexin V, single-strand DNA labelling and TUNEL). Myocyte apoptosis was first detected at 2 h, and peaked 4 h after clenbuterol administration. The lowest dose of clenbuterol to induce cardiomyocyte apoptosis was 1 microg kg(-1), with peak apoptosis (0.35 +/- 0.005 %; P<0.05) occurring in response to 5 mg kg(-1). In the soleus, peak apoptosis (5.8 +/- 2 %; P<0.05) was induced by the lower dose of 10 microg kg(-1). Cardiomyocyte apoptosis occurred throughout the ventricles, atria and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way from the apex towards the base. beta-AR antagonism (involving propranolol, bisoprolol or ICI 118,551) or reserpine was used to show that clenbuterol-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.

  3. #3
    BDTR's Avatar
    BDTR is offline Retired
    Join Date
    Jul 2003
    Clenbuterol is by far one of the more dangerous fatburners on the market, despite what people say. You should see an endocrinologist and have your thyroid function tested. If it's really low, then they will prescribe synthroid or something similiar to make it normal.

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