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  1. #1
    Giantz11's Avatar
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    ***Discussion*** ATD

    Please only chime in here if you want to have a serious conversation about the above topic. And please no "it's a Legal supp so it sucks", the real world feedback on ATD has been nothing but fantastic and it does have a chance of being banned when the loophole is finally closed.

    The compound is:
    1,4,6 androstatriene-3,17-dione

    There have been thoughts by some very bright minds that ATD is one of the best PCT compounds available as well as some other nice components. Author L Rea states that ATD could be used as a HCG type compound because it acts like a SARM. It block the androgen negative feedback loop in the hypothalamus as well as is Suicide Aromatase Inhibitor, helping keep natty test levels up in two ways. This all appears to be theory at this point but there are some convincing arguments.


    Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.

    Kaplan ME, McGinnis MY.

    Department of Anatomy, Mount Sinai School of Medicine, CUNY, New York 10029.

    The aromatization hypothesis asserts that testosterone (T) must be aromatized to estradiol (E2) to activate copulatory behavior in the male rat. In support of this hypothesis, the aromatization inhibitor, ATD, has been found to suppress male sexual behavior in T-treated rats. In our experiment, we first replicated this finding by peripherally injecting ATD (15 mg/day) or propylene glycol into T-treated (two 10-mm Silastic capsules) or control castrated male rats. In a second experiment, we bilaterally implanted either ATD-filled or blank cannulae into the medial preoptic area (MPOA) of either T-treated or control castrated male rats. With this more local distribution of ATD, a lesser decline in sexual behavior was found, suggesting that other brain areas are involved in the neurohormonal activation of copulatory behavior in the male rat.To determine whether in vivo ATD interacts with androgen or estrogen receptors, we conducted cell nuclear androgen and estrogen receptor binding assays of hypothalamus, preoptic area, amygdala, and septum following treatment with the combinations of systemic T alone.ATD plus T, ATD alone, and blank control. In all four brain areas binding of T to androgen receptors was significantly decreased in the presence of ATD, suggesting that ATD may act both as an androgen receptor blocker and as an aromatization inhibitor. Competitive binding studies indicated that ATD competes in vitro for cytosol androgen receptors, thus substantiating the in vivo antiandrogenic effects of ATD. Cell nuclear estrogen receptor binding was not significantly increased by exposure to T in the physiological range. No agonistic properties of ATD were observed either behaviorally or biochemically. Thus, an alternative explanation for the inhibitory effects of ATD on male sexual behavior is that ATD prevents T from binding to androgen receptors.
    Last edited by Giantz11; 02-23-2006 at 12:36 PM.

  2. #2
    Hackamaniac's Avatar
    Hackamaniac is offline King Without a Crown ~
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    great info giantz

  3. #3
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    Good reads as well, although don't take them as gospel:

    http://www.readthecore.com/200507/htpa.htm

  4. #4
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  5. #5
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  6. #6
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    Very good reads Ive tried the regular ATD and being a metabolite of aromasin it works very nicely!!!

    Im wondering giantz have you taken the 17aa version UHer

  7. #7
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    Quote Originally Posted by Bryan2
    Very good reads Ive tried the regular ATD and being a metabolite of aromasin it works very nicely!!!

    Im wondering giantz have you taken the 17aa version UHer
    No not yet and to be quite honest I didn't see the need for the methylation, ATD is quite effective on its own. Perhaps I will give it a shot though. However using while on cycle is really interesting theory to me.

  8. #8
    dkehzrd is offline New Member
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    would ATD be as effective as letro during cycle to prevent estrogen sides?

  9. #9
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    Quote Originally Posted by dkehzrd
    would ATD be as effective as letro during cycle to prevent estrogen sides?

    I'm positive that it could be, ATD seems to be very effective as an AI.

  10. #10
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    Bump......

  11. #11
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    One more.....

    Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.

    Slama A, Gogan F, Sarrieau A, Vial M, Rostene W, Kordon C.
    Exp Brain Res. 1986;64(3):407-10.

    Prevention of testosterone aromatization in the female rat pups by perinatal treatment with 1,4,6 androstatriene-3,17-dione (ATD) induces an important defeminization as shown by a reduction of fluctuations of LH release after castration and estradiol implantation. The fact that, under our in vitro experimental conditions, ATD is able to displace testosterone binding in the hypothalamus whereas estradiol does not, confirms the hypothesis that ATD acts on aromatase. The most attractive explanation for the defeminization effect of ATD is then an estrogen-like action of ATD.

  12. #12
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    good read

  13. #13
    Milky87 is offline Member
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    Quote Originally Posted by Giantz11
    The compound is:
    androst-4-ene-3,6,17-trione
    That would be 6-Oxo. ATD is, as you stated in a later post, 1,4,6-androstatriene-3,17-dione

  14. #14
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    Wow definitly interesting, but do you think it would have the same effect on HPTA as HCG while on cycle... as in would it work as quickly as HCG?

  15. #15
    SwoleCat is offline AR Hall of Fame
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    Dude, pffft, that's over the counter.

    That shit don't work!!! WTF??



































    ~SC~

  16. #16
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    Quote Originally Posted by Milky87
    That would be 6-Oxo. ATD is, as you stated in a later post, 1,4,6-androstatriene-3,17-dione

    Good call.

  17. #17
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    Quote Originally Posted by SwoleCat
    Dude, pffft, that's over the counter.

    That shit don't work!!! WTF??





































    ~SC~
    We're finished SC. Finished.

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