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  1. #1
    Cycleon is offline AR-Hall of Famer / Retired
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    Thumbs up new drug cuts BM 7% in 7 days! without raising heart rate!

    Excitement over weight loss drug


    Could a human version be produced?
    Monkeys given a new hormone-like compound lost a massive seven per cent of their body weight - in just one week. Researchers are now hopeful that a drug can eventually be developed to tackle the "obesity epidemic" threatening the West.

    The compound, called KB-141, works on the same principle as the hormone produced by the thyroid gland in the neck.

    It is well known that giving this to patients can produce weight loss by boosting the metabolic rate - so that the body burns more calories.

    However, this comes at a price, as the hormone also causes an potentially-dangerous increase in the heart rate.

    Scientists hoped that if they could somehow separate the two effects, then perhaps a drug could be made which would produce the weight loss without the heart problems.

    A team of researchers from the Karolinska Institute in Sweden and the University of California, in San Francisco, believe they have found a way to do this.

    Selective effect

    Thyroid hormone works by stimulating two main receptors on the body's cells.

    One of these, called TR-alpha, appears to control heart rate, while the other, TR-beta, appears to regulate the metabolism.

    They have developed an experimental chemical called KB-141 which they believe stimulates TR-beta, but not TR-alpha.

    Animals given the drug showed decreased cholesterol levels and reduced body weight, but crucially, without a faster heartbeat.

    When the compound was given to monkeys, there was a seven per cent drop in body weight over just seven days - with no effect on heart rate.

    "Our results in three species show that a separation between potential beneficial versus deleterious effects is possible," say the researchers, writing in the Proceedings of the National Academy of Sciences.

    Obese rise

    A drug which could control obesity is a "Holy Grail" for researchers, as record levels of the disease are recorded in many western countries.

    The research needs to proceed with caution - with longer term studies, probably in monkeys

    Professor John Lazarus, president, British Thyroid Association
    Drug companies are racing to find ways to stimulate the body to shed weight, with the promise of vast profits for a successful compound.

    Other areas of research include "gene therapies" designed to tackle genetic mutations that predispose to obesity, and drugs designed to reduce hunger.

    Professor John Lazarus, the president of the British Thyroid Association, said that the finding was "very exciting".

    He said that the effects on the heart meant that it was dangerous to give thyroid hormone supplementation to patients unless it was clear their own gland was not making enough.

    "This certainly shows promise - the amount of weight loss is impressive, although there are question marks over whether this loss could be sustained in a human patient.

    "The research needs to proceed with caution - with longer term studies, probably in monkeys."

    He said that it had to be proven that the new compound avoided another damaging side-effect of getting too much thyroid hormone - bone loss.
    ----------------------------------

    Man I would like to see what the LBM ratio on that is! if it were 80/20 fat to muscle - Good Lord that would change everything we know about BB!

  2. #2
    BDTR's Avatar
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    I'll offer myself to be their guinea pig.

  3. #3
    DF2003's Avatar
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    Wow

    I Am The Guinea Pig! Or Was It Lizard King I Forget. Wow That Would Be Great. Good Read Thx

  4. #4
    gundam675's Avatar
    gundam675 is offline Senior Member
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    what does it do to LBM ? i hope u dont need rediculously high dosages of AAS to keep them !

  5. #5
    MBaraso's Avatar
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    Sounds like the "Magic Pill" :-)

  6. #6
    FatMike is offline New Member
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    Why wait until the test it on guinea pigs or lizard kings, I'm a fuckin' monkey!

  7. #7
    chris1tr69 is offline Banned
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    Great post!

  8. #8
    symatech's Avatar
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    hmmm, While I am inclined to jump on the bandwagon and praise this new drug I must admit I have certain reservations when it comes to the "magic pill" as mbaraso so delicately put it.

  9. #9
    BigGreen's Avatar
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    Quote Originally Posted by gundam675
    what does it do to LBM ? i hope u dont need rediculously high dosages of AAS to keep them !
    That was the first thing I wanted to know...i'd love to get my hands on the official study to see if they measured simple mass loss, or accounted for fat free mass in the equation. I can't believe that something that "effective" could discriminate between fat and LBM.

  10. #10
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    If anyone is interested I dl'ed the entire research paper. It does look promising. I'm an idiot however when it comes to computers so if someone explains how to post it, I will.

    BG

  11. #11
    Cycleon is offline AR-Hall of Famer / Retired
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    baldguy - email it to me and I will post it up.

  12. #12
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    interesting

  13. #13
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    damn, thats a nice drug.. but i would like to know what effect it has on the body mass

  14. #14
    arby is offline Junior Member
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    i am curious about this, so if you want email it to me at arby@elitefitness.com and i will pdf it or whatever and upload it here.

    RB

  15. #15
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    ""When the compound was given to monkeys, there was a seven per cent drop in body weight over just seven days - with no effect on heart rate.""

    Man, that sounds sweet--cause my monkey is a fat ass.

  16. #16
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    I'm sending it to arby. I had to attach an acrobat reader file and couldn't figure out how to send it to you cycleon. Hopefully he'll post it.

    BG

  17. #17
    arby is offline Junior Member
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    The PDF file is too big, so I converted it to 6 seperate GIF files. Here they are.
    Attached Thumbnails Attached Thumbnails new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_1.gif   new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_2.gif   new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_3.gif   new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_4.gif  
    Last edited by arby; 08-03-2003 at 02:45 PM.

  18. #18
    arby is offline Junior Member
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    Errr... maximum of 5 files per post so I split them up.

    I really don't understand the point of these restrictions... the entire PDF was only 300k.
    Attached Thumbnails Attached Thumbnails new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_5.gif   new drug cuts BM 7% in 7 days! without raising heart rate!-kb-141_article_6.gif  
    Last edited by arby; 08-03-2003 at 02:43 PM.

  19. #19
    RON's Avatar
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    Its kinda hard to read like that. Cycle, maybe you can use you magic powers and make it a downloadable PDF or something.

  20. #20
    BajanBastard is offline VET Retired
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    Oh man i can't wait til this drug comes out! T3 will be obsolete! This is what is found on it. YES I KNOW THIS IS AN OLD ASS THREAD but i think it needs a bump.



    Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability.

    Grover GJ, Mellstrom K, Ye L, Malm J, Li YL, Bladh LG, Sleph PG, Smith MA, George R, Vennstrom B, Mookhtiar K, Horvath R, Speelman J, Egan D, Baxter JD.

    Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08534, USA. groverg@bms.com

    Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are desirable. Thyroid hormone receptors (TRs) regulate both body weight and cholesterol levels. However, thyroid hormones also have deleterious effects, particularly on the heart. The TR beta subtype is involved in cholesterol lowering and possibly elevating metabolic rate, whereas TR alpha appears to be more important for control of heart rate (HR). In the current studies, we examined the effect of TR beta activation on metabolic rate and HR with either TR alpha 1-/- mice or the selective TR beta agonist KB-141 in mice, rats, and monkeys. 3,5,3'-triiodi-l-thyronine (T3) had a greater effect on increasing HR in WT than in TR alpha-/- mice (ED15 values of 34 and 469 nmol/kg/day, respectively). T3 increased metabolic rate [whole body oxygen consumption (MVO2)] in both WT and TR alpha-/- mice, but the effect in the TR alpha 1-/- mice at the highest dose was half that of the WT mice. Thus, stimulation of MVO2 is likely due to both TR alpha and -beta. T3 had equivalent potency for cholesterol reduction in WT and TR alpha-/- mice. KB-141 increased MVO2 with selectivities of 16.5- and 11.2-fold vs. HR in WT and TR alpha 1-/- mice, respectively. KB-141 also increased MVO2 with a 10-fold selectivity and lowered cholesterol with a 27-fold selectivity vs. HR in rats. In primates, KB-141 caused significant cholesterol, lipoprotein (a), and body-weight reduction (up to 7% after 1 wk) with no effect on HR. TR beta-selective agonists may constitute a previously uncharacterized class of drugs to treat obesity, hypercholesterolemia, and elevated lipoprotein (a).

    Now the above study kb-141 vs T3 for heart rate, fat loss and cholesterol lowering.

    KB-141 basicly caused mad fat loss WITHOUT the nasty T3 sides increased heart rate etc, this is because KB-141 binds to the receptor to promote fat burning but not the one to control heart rate! It's like taking all of the positives of T3 and none of the negatives, cool stuff.

  21. #21
    tycin's Avatar
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    no shlt any word on when it will hit the streets?

  22. #22
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    Where Do I Sign Up?

  23. #23
    1-Cent's Avatar
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    IMO this will just make people even more lazy...

  24. #24
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    Quote Originally Posted by RON
    Its kinda hard to read like that. Cycle, maybe you can use you magic powers and make it a downloadable PDF or something.
    LoL, that was funny.

  25. #25
    BajanBastard is offline VET Retired
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    Quote Originally Posted by 1-Cent
    IMO this will just make people even more lazy...
    Are you nuts? Who wants to spend hours a week on a facking treadmill when you can take a drug? I sure as hell can find more fun things to do than jumping rope till my heart is ready to burst.
    Last edited by BajanBastard; 12-18-2004 at 09:01 AM.

  26. #26
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    LMAO at Big KLG

    so true

  27. #27
    wannaberipped23 is offline Junior Member
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    Quote Originally Posted by big k.l.g
    Are you nuts? Who wants to spend hours a week on a facking treadmill when you can take a drug? I sure as hell can find more fun things to do than jumping rope till my heart is ready to burst.

    **** RITE BRO,.... FVCK THAT!!

  28. #28
    workdude's Avatar
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    Interesting...

  29. #29
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    My beef:

    i've never seen a fat monkey.. so i'm assuming they almost definitely lost LBM.

  30. #30
    BajanBastard is offline VET Retired
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    Quote Originally Posted by chrisAdams
    My beef:

    i've never seen a fat monkey.. so i'm assuming they almost definitely lost LBM.
    I'm not at home now but i have an article showing that it was BF% loss. KB-141 stimulate brown fat cells to burn fat via UCPs i don't think UCP are catabolic. Besides the lab monkey could have been bred fat.

  31. #31
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    Quote Originally Posted by MMA
    how do you get into xperimntal trials? i live near a cluster of top universities, and i think some of the myostatin vaccine trials are near me too.

    BDTR, you're pretty close too. lets raid the lab tomorrow night. we can't take the chance of getiing stuck in the placebo group!
    ROFLMAO

  32. #32
    wannaberipped23 is offline Junior Member
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    I think the other name for this drug is..... DNP -600

  33. #33
    Scooby1 is offline Member
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    does anyone know whats happenig with this drug??

  34. #34
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    Sounds like I'lll need no cardio someday soon

  35. #35
    MER's Avatar
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    Who knows. Sounds too good to be true and it probably is.

  36. #36
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    Dear Lord,Please let this be the last post on this thread, and let it go to die. We are sorry for reseructing this old beast. Amen!

  37. #37
    Ultimate is offline Associate Member
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    sorry just had to be the last hehe

  38. #38
    BajanBastard is offline VET Retired
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    It's been 2 years. I can't find any 'new' info on this drug, anyone have anything?

  39. #39
    Merc.. is offline Steroidpedia
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    Quote Originally Posted by big k.l.g
    It's been 2 years. I can't find any 'new' info on this drug, anyone have anything?
    Man thats really strange you brought that up. I was just thinking about it the other day !! Where on the same brain wave BIG KLG LOL.. Bump for more input!!!

  40. #40
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    did some googling for KB-141...looks like theres no human version out as of yet...if this comes out it'll be a major breakthrough like the viagra pills were a couple of years ago....

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