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  1. #1
    Sheldon is offline New Member
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    Effective HCG Dosage

    Hi All

    I spoke to an endocrinologist yesterday who told me that dosages of HCG below 10000 units at a time is a waste. Does anyone have any comments?

  2. #2
    yerg is offline Associate Member
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    at a time????????!!!!! That would be my full multi dose bottle!!!!!

  3. #3
    THE RHINO's Avatar
    THE RHINO is offline New Member
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    .5cc every 5 days or .25 every 2. I prefer the .5 every 5th day.

    It may be that your Dr. meant the entire 10ml bottle which would equal the dosage of 10000 units.

  4. #4
    Mesomorphyl's Avatar
    Mesomorphyl is offline Smart Ass Member
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    He needs to become a better informed doctor... I would not go over 2000-3000iu every 4 days and that is with nolvadex ... Do not do 10000iu at one time.

  5. #5
    Drummerboy's Avatar
    Drummerboy is offline Anabolic Member
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    The problem with HCG is that it is not normally used for bodybuilding to prevent testicle shrinkage. It is used for fertility. Some men have problems producing sperm, and a one time super high dose of HCG may get enough out to cause pregnancy... ive read of doses like 50 000iu!! dont know if thats true, but doses for this purpose are high.... the problem is, after such a hit, the testicles can become PERMANENTLY desensitized to natural LH.... this means sterility for us... so the low dose is to prevent shrinkage only, and 500iu E4D is mild enough to not cause desensitization of the testicles, especially when used with nolvadex , which is thought to help stop the desensitizing effect of HCG.... so take em together while on cycle until longest ester has run out.... IMO anyway

  6. #6
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
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    Tell him to read this.

    Posted by hhajdo at S’ology

    Differential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization.

    Smals AG, Pieters GF, Boers GH, Raemakers JM, Hermus AR, Benraad TJ, Kloppenborg PW.

    This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 +/- 0.2 (SEM) X the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 +/- 0.1 X baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 +/- 0.2 X baseline) and then also fell to a nadir value of 0.6 +/- 0.2 X baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 +/- 0.1 X baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 +/- 0.6 X baseline] and the ratio E2/T (2.7 +/- 0.3 X baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 +/- 0.2 X baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 +/- 360 vs. 1647 +/- 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/T ratio fell to a nadir value of 0.6 +/- 0.1 X baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCG-induced increases in E2 and 17-OHP (r = +0.88, P less than 0.001), as well as the ratio 17 OHP/T (r = +0.64, P less than 0.02).

    JohnnyB

  7. #7
    JohnnyB's Avatar
    JohnnyB is offline AR-Hall of Famer / Retired
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    Quote Originally Posted by Mesomorphyl
    He needs to become a better informed doctor... I would not go over 2000-3000iu every 4 days and that is with nolvadex... Do not do 10000iu at one time.
    Those doses will not help, read the study I posted. Never go over 500iu

    JohnnyB

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