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Thread: Yohimbe

  1. #1
    MASTER's Avatar
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    Yohimbe

    What dose of yohimbe should i take for fat burning, I bought some by optimum, but it says only to take 2 tabs a day, how many do i need for fat burning?

  2. #2
    prolangtum's Avatar
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    herbal yohimbe is not very good. Find some yohimbine HCL

  3. #3
    Spyder Guest
    yohimbine is also considered an aphrodisiac ... you'll want to nail anything that walks by you

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    i got mine do a search for yocoral there 5mg tabs

    stuff makes me al jittery and gives me bad headaches

  5. #5
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    how many 5mg tabs wud u pop in a day, do u split doses and is the stuff actually any gd

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    1/2 a pill would make me sweet and all jittery

  7. #7
    MASTER's Avatar
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    i found scifit yohimbe, which is apparently 24mg yohimbine per serving, is that to much?

  8. #8
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    as far as i know there 2 different products, maybe someone else can chime in here

    yohimbine i thought could only be sold in 5mg pills

    the product your talking is from the bark .

  9. #9
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    bump !

    for any people who really know about yohimbe and yohimbine hcl !!! please post here !

  10. #10
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    http://www.*************.com/?ingredients_id=11
    Yohimbine Science
    By David Tolson


    1. What is yohimbine?

    Yohimbine is an alkaloid found in the inner bark of a tree that grows in southern Africa, Corynanthe yohimbe. Yohimbe has been used for centuries as an aphrodisiac, and alkaloids derived from this tree have been studied in depth. Yohimbine is now used primarily in veterinary medicine and in the treatment of erectile dysfunction, and it may also be useful in the treatment of obesity.

    2. What application does yohimbine have?

    Yohimbine has not been researched as thoroughly in the area of fat loss as many other weight loss aids, especially where clinical trials are concerned, but the existing data is promising. A 3-week study in 1991 on 20 obese females on 1000 calorie diets found that 20 mg of yohimbine daily increased weight loss 3 lbs. over placebo (1). Multiple studies have found that yohimbine increases the amount of non-esterfied fatty acids (NEFAs), a product of lipolysis (the breaking down of fat), in the bloodstream in both lean and obese individuals (2, 3), and that this effect persists for at least 14 days, indicating that rapid tolerance does not develop (4). Yohimbine is also an appetite suppressant, and decreases energy intake in both lean and obese mice (5).

    3. How does yohimbine work?

    Yohimbine works by blocking alpha(2) adrenoreceptors. There are a number of feedback mechanisms that prevent the release of norepinephrine (NE), one of the body's primary lipolytic hormones. When NE is released, such as in periods of stress or after taking a sympathomimetic (such as ephedrine), it stimulates both the alpha and beta adrenoreceptors. Stimulation of the beta adrenoreceptors causes the breakdown of fat while stimulating the alpha(2) adrenoreceptors has the opposite effect, preventing the release of NE and lipolysis. Yohimbine prevents this negative feedback mechanism, thus increasing NE release and lipolysis.

    There are a number of reasons why alpha(2) inhibition is specifically useful. First, while the beta-adrenergic system primarily controls lipolysis during periods of intense activity, during rest, which makes up most of our day, the alpha-adrenergic system is in control (6, 7). Also, "stubborn fat" areas – usually the abdominal area in men and the glutofemoral area in women – contain a higher ratio of alpha(2) receptors (7), making yohimbine particularly effective in these areas (whereas other drugs that increase NE may be somewhat counterproductive). Finally, alpha(2) blockade increases blood flow in adipose tissue (7), which prevents fat from being retained in the area (8).

    3. What other benefits does yohimbine have?

    Aside from being a fat loss agent, yohimbine is well known as a sexual stimulant. Studies indicate that it increases copulatory behavior and reduces sexual exhaustion in male rats (9, 10). A recent review of the literature found that yohimbine, especially in combination with drugs that facilitate the action of nitric oxide, is effective in the treatment of male erectile dysfunction (11), and a study in women found yohimbine combined with L-arginine glutamate to increase sexual arousal in women with sexual arousal disorder (12). Yohimbine also slightly raises serum testosterone levels in men (13).

    4. What are the side effects of yohimbine?

    Anxiety is the most common side effect seen with yohimbine, especially higher doses, and for this reason it should not be used by individuals prone to panic attacks or with stress-related disorders (14, 15). Other common side effects are increased heart rate and blood pressure, although these do not appear to be a problem at the doses used for weight loss (2, 3). Other side effects associated with elevated levels of NE, such as insomnia, can also be expected. All of these side effects disappear after termination of use (11).

    5. What form of yohimbine is best?

    Yohimbine is available as an herbal yohimbe extract or pure yohimbine HCl, and it is also found in some topical fat loss solutions. Yohimbe extracts contain a variety of alkaloids, and yohimbine only makes up 10-15% of the alkaloids present (16). The activity of many of these alkaloids is not well known, and some of them may have toxic effects (there are many reports that yohimbe is an MAOI), which makes pure yohimbine HCl both a safer and more consistent alternative. For those wishing to deliver a higher quantity to a specific "trouble area" without the side effects of systemic delivery, topical solutions (such as Lipoderm-Y) are effective (17).

    6. How should yohimbine be taken?

    The dosage of .2 mg/kg (approximately 1 mg per 10 lbs.) per day is relatively free of side effects and effective for weight loss (2, 3), while .1 mg/kg is more commonly used for sexual stimulant effects. For fat loss, yohimbine is generally taken twice daily, in the morning and afternoon. It is best taken on an empty stomach, as taking it with a meal can reduce its lipolytic effects (3). The half-life of yohimbine is short (1-2 hours), but the half-life of a metabolite with similar activity, 11-hydroxy-yohimbine, is 6-8 hours (18), so it is not necessary to take it every 2 hours. It is best to start with half the dose or less to see how sensitive you are to yohimbine, as inter-individual bioavailability and tolerance can vary greatly.

    7. What are some good supplements to take with yohimbine?

    As covered above, arginine and other NO enhancers may operate synergistically with yohimbine as a sexual stimulant. It is also probably synergistic with caffeine for fat loss through PDE inhibition.

    A possible synergism between yohimbine and ephedrine hasn't been thoroughly explored, and the information that exists is somewhat contradictory. In theory, they should work well together as yohimbine blocks one of the negative feedback mechanisms that would normally make ephedrine less effective. Cell culture studies confirm that yohimbine increases the lipolytic effects of beta(3) agonists (19). However, a study using rats indicated that yohimbine blocked the effects of the same beta(3) agonist, indicating that the two may antagonize each other (19). Additionally, a study on cardiovascular variables found that ephedrine and caffeine together were safe, but the addition of yohimbine may produce undesirable effects (20). So it is still unknown whether the combination of yohimbine and ephedrine produces any additional benefit, and whether it is justified by the potential dangers.


    If you have any questions or comments regarding this article, please email dvdtlsn@*************.com.


    No part of this article may be reproduced in any form without the permission of David Tolson or Mike McCandless.

  11. #11
    nsa
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    Quote Originally Posted by JamesC
    i found scifit yohimbe, which is apparently 24mg yohimbine per serving, is that to much?
    24 mg of yohimbine per serving IMO would be overkill. All you need is 5 mg to be effective and keep in mind that yohimbine is also a monoamine oxidase inhibitor (MAOI) so be careful with what other compounds you take in conjunction with yohimbine, especially amino acids. Some amino acids that are normally broken down by the enzyme monoamine oxidase can be dangerous or even lethal when taken along with a MAOI.

  12. #12
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    thx prolangtum !

  13. #13
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    no problem I myself like yohimbine pre workout with caffiene, 400mg caffiene/10mg yohimbine HCL. Most will do fine with 5mgs. 5mgs insulffated pre workout is a nice kick occasionally too.

  14. #14
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    Nsa what compounds are dangerous to take with it then, and what sort of time period between taking them and yohimbine wud b safe?

  15. #15
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    when i was younger i got some yohimbe bark pills for energy and it works allright and it does make you kinda more horny ha ha!

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