System Admin review Insulin Profile

[TexasFitnessGirl]

I. Drug History



Insulin is a proteinaceous hormone which is manufactured in the pancreas and which has a number of important physiological actions in the body. It's a polypeptide made from 51 amino acids, separated in an A and B chain by a sulfide bridge (Covalent bond). It is an essential hormone in maintaining the body's blood glucose level so that the brain, muscles, heart and other tissues are adequately supplied with the fuel they require for normal cellular metabolism and normal function. Insulin also plays an essential role in fat and protein metabolism. For example, it promotes transport of amino acids from the bloodstream into muscle and other cells. Within these cells, insulin increases the rate of incorporation of amino acids into protein (amino acids are the building blocks of protein) and reduces protein break down in the body ("catabolism"). These physiological actions probably form the basis regarding the additional anabolic gains which might be made through the use of exogenously administered insulin.



Normally, blood glucose and blood insulin levels are not both elevated for any extended period of time as these two chemicals influence each other through a feedback system in the body. In the post-absorptive state, the blood insulin concentration tends to decrease during exercise, allowing the blood glucose to be maintained at or above resting levels and to provide increased energy supplies (fuel) to muscle cells. Following a meal, the blood glucose and amino acid levels rise (the absorptive state) and this triggers an increase in insulin release from the pancreas, driving glucose and amino acids from the blood into cells and maintaining the blood glucose level within a certain physiological (operating) range.



Medically, Insulin is typically used in the treatment of diabetes. Diabetes is a disease that affects the body's ability to produce or respond to insulin, a hormone that allows blood sugar to enter the cells of the body and be stored or used for energy. Type 1 diabetes occurs when a person no longer is capable of making any insulin. This type of diabetes usually begins in childhood, adolescence, or young adulthood and requires insulin injections for treatment. Type 2 diabetes occurs when a person becomes resistant to his or her own insulin, thereby creating a need for greater amounts of insulin. This type usually happens after age 45. Type 2 diabetes is closely linked with obesity.



Bodybuilders use insulin due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscle. Insulin can also help athletes' stamina by providing then with "fuel" - glycogen, which stores carbohydrate energy - by taking insulin and glucose.



At one time, all insulin was produced by laboratory animals, most often cows and pigs. In the last decade, however, American insulin manufacturers have almost completely shifted to use of "recombinant DNA" technology, enabling laboratory production of a close analog to real human insulin. This "human" insulin is said to more closely match our endogenous (pancreatic) insulin.



Although labeled much like "animal source" insulin’s, recombinant DNA insulin’s are not quite the same, either in time-of-onset or in amount of insulin required. Experience shows that any switch between the one and the other must be done with care, and under your doctor's supervision. Use human insulin rather than an animal insulin preparation if possible (there is little animal insulin available now).



There are three types of non-prescription insulin. Short-acting, “regular” insulin which is mostly used, commonly known as Humulin-R, also Actrapid, Insulin Neutral, Humulin R, Hypurin Neutral). These slower acting insulins effect Blood Glucose levels to a lesser degree and are generally considered to be safer than longer acting insulin. Then there is an intermediate form (Humulin-N or Humulin-L) which can last almost three times as long, which means up to a day. And lastly there is the Humulin-U, which stays active for longer. Particularly useful for diabetics who may forget their shots, as it stays active longer than a day. There is the fast-acting form called Humalog, this type is only available via prescription in the US. Most bodybuilders prefer the fast acting insulin such as Humalog because of the rapid onset. The quick action of the insulin is important because muscles posses a short window of recovery, and in regards to muscle growth - rapid nutrient disbursement is crucial. There are also mixtures of short and fast acting insulin but for non-diabetics the mixed types are not recommended.





• Substance name



US Manufacturers



Eli Lilly and Company and Novo Nordisk Pharmaceuticals Inc.



In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company, the company also produces 5 other insulin formulations, but none of these should be used by bodybuilders.



Humulin R is the considered the safest because it takes effect in a fairly short amount of time but does not stay in the body for a long time period. The slow acting insulin formulations remain active for a longer time period thus the user has to monitor BGL for a longer period of time, the fast acting insulins onset is very quick so carb/sugar consumption has to occur immediatley following the injection - both of the latter can put an inexperienced user in an unexpected state of hypoglycemia.





• Date created



Eli Lilly and Company was the first to isolate and purify insulin for the treatment of diabetes, then a fatal disease with no effective treatment options. The work resulted in Lilly's introduction of Iletin, the world's first commercially available insulin product, in 1923.





• Medical Use / dosing



Injections are the most common delivery system.

Insulin pens are very convenient - look like a pen with a cartridge which holds 100 to 200 units of insulin.



Be aware that 1.0 ml of insulin contains one hundred International Units (100 IU), 0.1 ml of insulin contains ten (10) IU and 0.01 ml contains one (1.0) IU.

Note that 0.01 ml is the volume contained in the space between the smallest graduated markings on a 1.0 ml Terumo diabetic syringe.


All insulins sold in the United States today are of U-100 strength, 100 units of insulin per cc of fluid. But there are other dilutions in other countries, and if you were to encounter one of these (all perfectly usable), and inject your usual volume of insulin, you would get a higher dosage of insulin. Insulin manufactured outside the US and in higher units of cc per fluid is for use in Insulin pumps and should not be injected.



Inject about 1 IU per 10-20 pounds of lean bodyweight of insulin immediately following a workout when GH is surging. Manipulation of GH/insulin synergy is an effort to both dramatically enhance the anabolism of muscle tissue and reduce the fat accumulation that insulin would cause if used alone. It seems that post-workout timing is the key to maximum potential.



First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. It is unadvisable to exceed 10 IUs for your first Insulin cycle. This will allow you to safely determine a dosage. Insulin dosages can vary significantly and are dependent upon insulin sensitivity and the use of other drugs. First time users should inject only once a day for the first cycle.



Humilin R should be injected by the subcutaneous route (injecting just under the skin and preferably in the abdominal area or outer part of the upper thigh), (with a U-100 insulin syringe) not intramuscularly or intravenously as using the latter routes can lead to a rapid rise in blood insulin level and a sudden hypoglycemic episode.





• Androgenic-Anabolic Ratio/Aromatization



Insulin is not Androgenic but Anabolic, nor is it a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands...



So how is insulin anabolic? Insulin is a partitioning agent. If blood sugar levels are too high insulin is released, which stores more glucose in the cells as the polysaccharide glycogen, the prime energy source in the human body. This alone makes it a valuable hormone. But it also increases the uptake of other compounds into the cell. This includes protein. Since anabolic steroids increase protein synthesis, and we eat lots of protein, the only thing missing in that system is a way to get the amino acids to where the protein is synthesized. Insulin can do that.



In laymens terms....picture insulin as a transport system. Insulin aids in transporting nutrients where they need to go, it enables anabolism and is therefore it is anabolic.



Its interesting to note that insulin does not have a direct negative feedback system like steroids do. When blood sugar levels drop, cells simply become more resistant to the insulin and don't receive as much of an impulse to store glycogen as they would at first. This is important, as it will have certain implications. If not used properly.





II. Performance Uses and Effects



Insulin is often referred to as “the most anabolic hormone”. Unfortunately, this means it builds adipose tissue as well as muscle. Endogenous (naturally-produced) insulin production is reduced during and immediately after exercise. This is mostly due to the effects of increased circulating catecholamine (epinephrine and norepinephrine). These “fight or flight” hormones put the damper on one’s pancreas. This is too bad for bodybuilders since GH may really be flowing at this time (depending on meal timing, age, etc.) and it seems to have very, synergistic anabolic effects when present at the same time as insulin.



Research has shown that GH or insulin alone has little effect on weight gains, but when injected together there is evidence of a dramatic effect. It’s speculated that GH stimulates uptake of about half of the 9 or so essential amino acids into muscle, while insulin stimulates the uptake (or prevents the loss) of the complimentary half. All must be present for protein synthesis, since this does not occur naturally the two should be “injected together”. (GH and insulin are largely counter-regulatory (and not naturally present together).





• General Information



To further increase the effects of this powerful combination, a relatively mild aerobic or weight workout at least 4-5 hours apart from the “main” training session, can be used to get another GH surge and thus a second chance during the day to use insulin when it’s most effective. This second workout of the day need only be about 10-20 minutes in duration and at a moderate intensity to elicit a GH surge that lasts 15-40 minutes after exercise. This will up the anabolic drive, generally speaking you will lose existing fat because this minimal cardio workout won’t do much from a (fat) calorie-burning point of view. (Using a beta-2 adrenergic agonist like clenbuterol or an ephedra/yohimbe blend would only serve to suppress GH release as well.) This “two-a-day” approach is primarily for anabolic purposes.





• Effects on Body Composition



Growth Hormone in regards to muscle growth has shown to do very little without testosterone and/or insulin. The anabolism GH induces alone is largely organ mass and insulin is not only acutely dangerous if used improperly, it’s also likely to induce some serious fat gain if used alone. Together, however, there is the potential for enhanced muscle recovery and growth without tremendous fat accumulation.





• Goal-Orientated Cycling (examples)



6-8 week cycles

It is important to note, if you use the long acting insulin rather than the short or regular, you will have to monitor your glucose levels for atleast 24 hours and keep glucose (dextrose) on hand for the entire duration. This is the reason that Humulin R or Humalog are the preferred sources, and not a long acting insulin!

Start with no more than 5 IU (0.05 ml) of this short acting/ regular insulin preparation and increase the dose gradually over a period of one week, to a dose no higher than 20 IU (0.20 ml) per day. Doses above this will expose you to progressively greater risk and most bodybuilders who use insulin believe there is no advantage in taking doses higher than this. Anecdotal evidence amongst bodybuilders suggests increased doses leads to excess body fat accumulation.



For optimal results, use immediately after training (Post Work Out) because that is when your body is most depleted of Glycogen stores and is primed to overcompensate for the influx of nutrients. Insulin hits in 5-15 minutes so you must immediately ingest 10 grams of simple carbohydrates for every IU of insulin you inject. Taking in additional nutrients help contribute to muscle growth, such as amino acids whey isolate. Also have 5 grams of creatine at this time will aid in cell volumizing.



The best case scenario would be to do this twice a day (the more you deplete your Glycogen stores, the more of an opportunity you have to use insulin.) If you choose to inject twice daily you increase the risk of entering a hypoclycemic state. The General information section above gives detail on a two-a-day injection routine.



Immediately after, you should have a carbohydrate drink, again you should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. You can also take creatine monohydrate with the carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and you will most likely go into a state of hypoglycemia. Note: Sugar water will absorb the fastest, minimizing the risk as opposed to other carbs. Mix 150 grams of sugar in water and consume within 20 minutes of the injection and keep a glass with another 150 grams handy. If you finish the glass, immediately prepare another until the insulin has cleared the blood.



It is a good idea to invest in a Blood Glucose Monitor. It is a battery operated device that quickly and easily test Blood Glucose Levels. Monitors can be purchased at drug stores for about $15.00.





The Glycemic Index Factor:



Scientists have discovered that carbohydrate containing foods can be measured and ranked on the basis of the rate and level of blood glucose increase they cause when eaten. This measurement is called the "Glycemic Index" or "G.I. factor". The rate at which glucose enters the bloodstream affects the insulin response to that food and ultimately affects the rate at which this glucose (fuel) is made available to exercising muscles. Review the Glycemic Index to understand the G.I. factor to determine what foods are best to consume following an insulin injection.







III. Side Effects and Precautions



Insulin has one of the highest potentials for danger of all bodybuilding drugs. Use requires complete discipline and control. Insulin misuse should not be taken lightly because death can occur.



Repeated Insulin use in a non diabetic can cause you to become Insulin dependent. Misuse can also contribute to obesity.



The major risk associated with insulin is a physical state known as hypoglycemia or "low blood sugar". This occurs when the level of glucose in the blood falls below a certain level required for normal body function. If the blood glucose level is substantially reduced below this normal level and if this is not quickly corrected, there is a risk of disorientation, collapse, coma, permanent brain damage and even death. Exercise and reduced food intake decreases the body's need for insulin and increases the risk of hypoglycemia associated with non-medical use of insulin.



Hypoglycemia occurs when blood glucose levels are too low. It is a common and before you begin taking insulin, it is critical that you understand the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, you should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death.



It is possible to become sleepy after injecting insulin. This may be a symptom of hypoglycemia, and you should consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during his slumber, you are at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting.



Rather than waiting to the end of a workout, you may prefer to inject the insulin dosage 30 minutes before the training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. You may inject a few IUs before lifting to improve a pump, but this practice is extremely risky and best left to experienced insulin users. Finally, you may inject insulin upon waking in the morning. After the injection, consume a carbohydrate drink and then have breakfast within the next hour. Some find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way.



However, before you attempt to use insulin, you should educate yourself and make yourself aware of the consequences. One mistake in dosage or diet can be potentially fatal.



It is difficult to provide a quantitative estimate of risk for any drug but on a scale of risk in relation to other non-medical and unsanctioned drug use, the use of insulin in this manner would rank towards the higher end of the scale. If zero equals "no risk" of harm to a person's health and ten equals "extreme risk", the use of anabolic steroids in a non-medical context might rate towards the middle of the scale of risk (particularly in the medium to long term) whilst insulin would rate higher.





• Metabolites and Drug Detection Time



Insulin use can not be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete.





• Drug Half life



Humulin R – a short acting insulin that begins to work within an hour but stops working sooner than intermediate or long-acting insulins. Peaks 2 to 4 hours. Duration 6 to 8 hours



Humalog -- rapid acting insulin is an analog of recombinant DNA technology in which two amino acids of the human insulin molecule -- proline and lysine -- have been reversed. It begins to work in 15 to 30 minutes, peaks 1 1/2 to 2 hours, and lasts 4 hours, has a half-life of about one half hour.





• General Concerns



Consider using the natural method listed below to raise your blood insulin level during workouts by consuming glucose containing fluids at intervals during exercise. These fluids may have a protein sparing effect and at the same time, will help maintain keep your blood glucose and blood insulin levels. However, if you decide to use insulin, you should consider the following advice:



Don't use medium or long acting insulin in the middle or latter part of the day, as you may very well experience a hypoglycemic attack whilst you are asleep. If this happens, neither you nor anyone else will be aware of or able to respond to your urgent need for glucose, in order to prevent possible serious harm.



If you are going to use insulin, it is essential that you have a friend or peer observer remain with you in case you experience problems. This person really needs to be with you for the whole time while the insulin preparation used is working.



Be aware that the risk of hypoglycemia occurs not at the time of insulin injection but rather, when the insulin starts to take effect. The risk will be greatest when your insulin blood level nears or reaches its highest level, usually 30-60 minutes afterwards if a short acting insulin preparation is used (by subcutaneous injection) and up to 20 hours later if a long acting insulin is used.



***A Natural Method of Maintaining an Elevated Blood Insulin Level:

Noting the hypothesis that an elevated blood insulin level may be of some advantage to bodybuilders, a liquid meal consisting of 13.0 g protein, 31.9 g carbohydrate and 2.6 g fat per 100 ml and provided 825 kJ of energy.



It is possible with such intermittent feeding during intense weight training to maintain a person's blood glucose at or above resting levels and at the same time, significantly increase insulin levels for the duration of the workout. This suggests a potentially effective and safe non-drug method for achieving a sustained elevation of blood insulin levels.



It is also relevant to note that muscle repair and growth begins in the hours and days following heavy exercise. It is doubtful that the use of insulin just prior to a workout will have any anabolic effects over and above natural processes, at this time. However, use of insulin prior to a workout will certainly expose you to much greater risk of serious harm. If you believe it is beneficial to have a higher insulin blood level during workouts, try the natural method outlined here.



Intending users should also be aware that insulin stimulates lipid (fat) synthesis from carbohydrate ("lipogenesis"), decreases fatty acid release from tissues ("lipolysis") and leads to a net increase in total body lipid stores. The development of such increased body fat stores runs counter to the training goals of most body builders, athletes and those seeking to improve their physical appearance.





IV. Availability



Humulin-R can be bought over-the-counter for around $20 / 10 cc. (10 ml vial with strength of 100 IU per ml) bottle. Humalog for around $30.95.





• Manufactures



Eli Lilly and Company and Novo Nordisk Pharmaceuticals Inc.





• Counterfeits



Since Insulin can be readily purchased over the counter, counterfeiting of Insulin is not common as with steroids or illegal drugs. Check the packaging to be sure to note the manufacturer and brand name of the insulin you purchase.





• Miscellany



Insulin should be refrigerated and kept away from excessive heat.



Experience

Of the Non-Diabetic Anabolic Review users polled

11% preferred regular acting Insulin such as Humulin R
89% preferred fast acting Insulin such as Humalog
0% preferred slow acting Insulin.


91% experiencd positive results and will use it again
9% experienced positive results but felt the risk factor was too high or
there was too much involved and would not consider another cycle
0% experienced negative results



72% experienced positive results when used with a combination of HGH
and Steroids
21% experienced positive results when used with Steroids
7% experienced positive results when used with HGH

[joevette]

Looks good, but I would also discuss IM insulin use since that's really the best way. You could explain the activity times between subq and IM injections. Also, under your cycling examples I would specify the two times of the day you are speaking of. One in the morning and one PWO is what most two-a-dayers do, unless you workout in the morning then I don't know. Also, the generally recommended dosage to work up to is 10ius, I don't think a beginner should venture any higher or use more than once a day.

[Daven]

Ive read most of that before, but i also think you should put some reaslistic information in there. Most people will want to start insulin and think it will put mass on them alone, and it really doesnt happen.

[AnabolicBoy1981]

Ive read most of that before, but i also think you should put some reaslistic information in there. Most people will want to start insulin and think it will put mass on them alone, and it really doesnt happen.

reread it. It did say that. Unless she just edited it before i read it.

Anyway, shouldn't this be in the Insulin , GH, and IGF-1, forum?

[PT]

very, very good post. im impressed.

[DEVLDOG]

"Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia."

i believe ths should read HUMALOG is the safest....etc.humalog shot IM Is in and out wthin 2hrs

[DEVLDOG]

heres a slin profile from the big cat.there are some things in here you may want to touch on.


--------------------------------------------------------------------------------

Insulin



Effective dose: 5-15 IU/ day
Average Street-price: $20 for each 10 ml vial (1000 IU)
Available Doses: Humulin-R is most used, and is available without prescription at any pharmacy in 10 ml vials.

Characteristics:

Insulin is not an androgen, or a steroid for that matter. Insulin is a proteinaceous hormone that is secreted from the pancreas, mostly in response to high sugar levels. It's a polypeptide made from 51 amino acids, separated in an A and B chain by a sulfide bridge (Covalent bond). Its main use is to regulate blood sugar levels. If blood sugar levels are too high insulin is released, which stores more glucose in the cells as the polysaccharide glycogen, the prime energy source in the human body. This alone makes it a valuable hormone. But it also increases the uptake of other compounds into the cell. This includes protein. Since anabolic steroids increase protein synthesis, and we eat lots of protein, the only thing missing in that system is a way to get the amino acids to where the protein is synthesized. Insulin can do that. Its interesting to note that insulin does not have a direct negative feedback system like steroids do. When blood sugar levels drop, cells simply become more resistant to the insulin and don't receive as much of an impulse to store glycogen as they would at first. This is important, as it will have certain implications.

Insulin was designed for diabetics, a disease marked by one characteristic : too much blood sugar due to an insulin deficiency. There are two types of diabetics, but this is irrelevant to the discussion at hand. As with anabolic androgenic steroids, taking endogenous insulin will shut down natural pancreatic secretion action. This is not as easily solved as with steroids, where production eventually bounces back. Warning number 1 : Insulin use can, and in the long run will, make you a life-time diabetic. Keep that in mind before you decide that insulin might be for you. On the one hand this is a good way to get a discount maybe, on the other hand, injecting daily for the rest of your life is not a pleasant outlook. On second thought scratch that, there is no positive side as insulin is available freely without prescription at a fairly low cost. This is because when a diabetic does not get his insulin in time it may be fatal. When a diabetic goes into seizure you don't want to waste time going to a doctor to quickly obtain a prescription. By then its too late.

There are three types of non-prescription insulin. Fast-acting, which is mostly used, known as Humulin-R. Then there is an intermediate form (Humulin-N or Humulin-L) which can last almost three times as long, which means up to a day. And lastly there is the Humulin-U, which stays active for longer. Particularly useful for diabetics who may forget their shots, as it stays active longer than a day. There is also a really fast-acting form called Humalog, but this is only available via prescription since it's the most easily abused and the Humulin-R suffices for most diabetics. Humulin-R is the compound most used by the way because it's the shortest acting form. Yes, that's a good thing. In fact it's a very good thing. When administering supra-physiological doses of insulin, more glucose is stored as glycogen resulting in a lower blood sugar level. When your blood sugar level is too low, its called hypoglycemia and it can cause you to go into shock and die. Warning number 2 : If proper protocol for using insulin is not followed, you can die. This has two definite implications. First of all it explains why you want the short-acting form. Blood sugar levels need to be monitored over the active time, so you obviously don't want it to stay active for 24 hours or longer. The second implication is that obviously sugar has to be taken with the insulin to prevent hypoglycemia and sugar needs to be kept on hand for the entire duration of activity, which is 6-8 hours. If dizziness or weakness occurs, more sugar has to be taken. This will be discussed in the how to use section.

Initially, doses of insulin will make you leaner as you store more carbs that would otherwise be stored as fat. But as people will tell you, it eventually has a tendency to make you fat. As indicated earlier, there is no negative feedback, but cells develop a resistance to insulin, in which case circulating excess carbs will be processed as adipose tissue. And if you know what's good for you, you will have circulating extra carbs.

Stacking and Use:

Insulin is obviously best stacked with some form of anabolic androgenic steroid. Its mostly added to stacks including the extremely expensive human growth hormone .

Its proper use entails a single shot once a day of a short-acting compound. Usually Humulin-R, unless Humalog can be obtained. Its best used after a training session, when the body already has a tendency to store more carbs and protein. Although some people prefer other times of day. The standard protocol suggests the use of 1 IU per 20 pounds of bodyweight, but you would do best to start out at a lower dose like 2-4 IU and then work your way up a bit, until you feel you are taking enough. As doses increase, so does the amount of sugar that is ingested with them. Again a standard of 10 grams per IU is given, but I would recommend a dose of 150 grams regardless of the amount as long as it is below 15 IU's, if it is higher then add 10 grams for every IU. Since the compound stays active for 6-8 hours, hypoglycemia can occur at any moment during this time span. So consuming carbs during this time is advised, and at the very least keep a large amount of them handy, so you can act quickly. Dizziness, weakness and feeling sleepy are all pretty indicative of the onset of hypoglycemia and a good sign that you should take another good dose of sugar.

The carb source suggested here should be glucose (dextrose). This is basically blood sugar and will absorb the fastest, minimizing the risk as opposed to other carbs. Mix 150 grams in water and consume within 20 minutes of the injection and keep a glass with another 150 grams handy. If you finish the glass, immediately prepare another until the insulin has cleared the blood.

Again a reminder of the high risk involved with insulin. It can make you a life-long diabetic and in the worst case, it can kill you. I strongly advise against the use of insulin compounds. Should you not heed my warning, follow the protocol to the letter. One slip could mean your life.

[TexasFitnessGirl]

heres a slin profile from the big cat.there are some things in here you may want to touch on.


--------------------------------------------------------------------------------

Insulin



Effective dose: 5-15 IU/ day
Average Street-price: $20 for each 10 ml vial (1000 IU)
Available Doses: Humulin-R is most used, and is available without prescription at any pharmacy in 10 ml vials.

Characteristics:

Insulin is not an androgen, or a steroid for that matter. Insulin is a proteinaceous hormone that is secreted from the pancreas, mostly in response to high sugar levels. It's a polypeptide made from 51 amino acids, separated in an A and B chain by a sulfide bridge (Covalent bond). Its main use is to regulate blood sugar levels. If blood sugar levels are too high insulin is released, which stores more glucose in the cells as the polysaccharide glycogen, the prime energy source in the human body. This alone makes it a valuable hormone. But it also increases the uptake of other compounds into the cell. This includes protein. Since anabolic steroids increase protein synthesis, and we eat lots of protein, the only thing missing in that system is a way to get the amino acids to where the protein is synthesized. Insulin can do that. Its interesting to note that insulin does not have a direct negative feedback system like steroids do. When blood sugar levels drop, cells simply become more resistant to the insulin and don't receive as much of an impulse to store glycogen as they would at first. This is important, as it will have certain implications.

Insulin was designed for diabetics, a disease marked by one characteristic : too much blood sugar due to an insulin deficiency. There are two types of diabetics, but this is irrelevant to the discussion at hand. As with anabolic androgenic steroids, taking endogenous insulin will shut down natural pancreatic secretion action. This is not as easily solved as with steroids, where production eventually bounces back. Warning number 1 : Insulin use can, and in the long run will, make you a life-time diabetic. Keep that in mind before you decide that insulin might be for you. On the one hand this is a good way to get a discount maybe, on the other hand, injecting daily for the rest of your life is not a pleasant outlook. On second thought scratch that, there is no positive side as insulin is available freely without prescription at a fairly low cost. This is because when a diabetic does not get his insulin in time it may be fatal. When a diabetic goes into seizure you don't want to waste time going to a doctor to quickly obtain a prescription. By then its too late.

There are three types of non-prescription insulin. Fast-acting, which is mostly used, known as Humulin-R. Then there is an intermediate form (Humulin-N or Humulin-L) which can last almost three times as long, which means up to a day. And lastly there is the Humulin-U, which stays active for longer. Particularly useful for diabetics who may forget their shots, as it stays active longer than a day. There is also a really fast-acting form called Humalog, but this is only available via prescription since it's the most easily abused and the Humulin-R suffices for most diabetics. Humulin-R is the compound most used by the way because it's the shortest acting form. Yes, that's a good thing. In fact it's a very good thing. When administering supra-physiological doses of insulin, more glucose is stored as glycogen resulting in a lower blood sugar level. When your blood sugar level is too low, its called hypoglycemia and it can cause you to go into shock and die. Warning number 2 : If proper protocol for using insulin is not followed, you can die. This has two definite implications. First of all it explains why you want the short-acting form. Blood sugar levels need to be monitored over the active time, so you obviously don't want it to stay active for 24 hours or longer. The second implication is that obviously sugar has to be taken with the insulin to prevent hypoglycemia and sugar needs to be kept on hand for the entire duration of activity, which is 6-8 hours. If dizziness or weakness occurs, more sugar has to be taken. This will be discussed in the how to use section.

Initially, doses of insulin will make you leaner as you store more carbs that would otherwise be stored as fat. But as people will tell you, it eventually has a tendency to make you fat. As indicated earlier, there is no negative feedback, but cells develop a resistance to insulin, in which case circulating excess carbs will be processed as adipose tissue. And if you know what's good for you, you will have circulating extra carbs.

Stacking and Use:

Insulin is obviously best stacked with some form of anabolic androgenic steroid. Its mostly added to stacks including the extremely expensive human growth hormone .

Its proper use entails a single shot once a day of a short-acting compound. Usually Humulin-R, unless Humalog can be obtained. Its best used after a training session, when the body already has a tendency to store more carbs and protein. Although some people prefer other times of day. The standard protocol suggests the use of 1 IU per 20 pounds of bodyweight, but you would do best to start out at a lower dose like 2-4 IU and then work your way up a bit, until you feel you are taking enough. As doses increase, so does the amount of sugar that is ingested with them. Again a standard of 10 grams per IU is given, but I would recommend a dose of 150 grams regardless of the amount as long as it is below 15 IU's, if it is higher then add 10 grams for every IU. Since the compound stays active for 6-8 hours, hypoglycemia can occur at any moment during this time span. So consuming carbs during this time is advised, and at the very least keep a large amount of them handy, so you can act quickly. Dizziness, weakness and feeling sleepy are all pretty indicative of the onset of hypoglycemia and a good sign that you should take another good dose of sugar.

The carb source suggested here should be glucose (dextrose). This is basically blood sugar and will absorb the fastest, minimizing the risk as opposed to other carbs. Mix 150 grams in water and consume within 20 minutes of the injection and keep a glass with another 150 grams handy. If you finish the glass, immediately prepare another until the insulin has cleared the blood.

Again a reminder of the high risk involved with insulin. It can make you a life-long diabetic and in the worst case, it can kill you. I strongly advise against the use of insulin compounds. Should you not heed my warning, follow the protocol to the letter. One slip could mean your life.

Thanks guys I will work on the things you gave me. Many many thanks!

[TexasFitnessGirl]

"Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia."

i believe ths should read HUMALOG is the safest....etc.humalog shot IM Is in and out wthin 2hrs

I will have to research this more, because from what I have been reading the slow acting insulin is in fact the safest because of the warning time for possible Hypoglycemia? Am I wrong???

Thanks for the post, where have you been kinda missed hearing from you!

[Money Boss Hustla]

TFG...great to see you can take constructive criticism!!

[TexasFitnessGirl]

TFG...great to see you can take constructive criticism!!

Thanks, want it to be the best so since I am just basically copying what everything says don't want to miss anything that is important.

[DEVLDOG]

I will have to research this more, because from what I have been reading the slow acting insulin is in fact the safest because of the warning time for possible Hypoglycemia? Am I wrong???

Thanks for the post, where have you been kinda missed hearing from you!

man..thats really a catch 22 there.on one hand humalog is in and out of your system very quickyl,shot IM it peaks in an hour,shout sub q about 2 hrs.so you have to have your carbs(preferably dextrose) on hand immediately.but within 2 hrs its out and you can go back to your regular diet without fear of hypo.humalog is the only slin i have used.so i really cant comment on any other type other more then what i have read.i know though that while the slin is active wether it be humalog or humalin r or whatever you are always at risk of sudden spikes.so i would think it would be much safer to not have to deal with this for 6hrs or more.you really only want it for that pwo and ppwo meals just enough time to get all the nutrients where you really want them.after that its just a matter of staying out of hypo.
i hope that helps

[TexasFitnessGirl]

man..thats really a catch 22 there.on one hand humalog is in and out of your system very quickyl,shot IM it peaks in an hour,shout sub q about 2 hrs.so you have to have your carbs(preferably dextrose) on hand immediately.but within 2 hrs its out and you can go back to your regular diet without fear of hypo.humalog is the only slin i have used.so i really cant comment on any other type other more then what i have read.i know though that while the slin is active wether it be humalog or humalin r or whatever you are always at risk of sudden spikes.so i would think it would be much safer to not have to deal with this for 6hrs or more.you really only want it for that pwo and ppwo meals just enough time to get all the nutrients where you really want them.after that its just a matter of staying out of hypo.
i hope that helps

After everything I have read I really agree with you, I would rather deal with it immediately and then go on, but most things I have read say that it is better for the slower acting. I will put the info on both pos and neg and then the person will have to decide! I appreciate the help, so much!

[DEVLDOG]

no problem TFG..there are alot of smart bros that post on the GH,IGF,SLIN forum,whos brains you could pick.
goodluck

[Mallet]

I will have to research this more, because from what I have been reading the slow acting insulin is in fact the safest because of the warning time for possible Hypoglycemia? Am I wrong???

Thanks for the post, where have you been kinda missed hearing from you!

Your correct in saying that the slower acting slin effects your BG levels to a lesser degree ( hypo ) but you have toi take into consideration that using the slower or longer acting slin requires you to limit your fat intake for longer periods of time as well. I beleive this information may have been writen before humalog was on the market, so i think hunulin R is still useful especially sinse it's legal i beleive in more states than humalog is and both are legal in canada..but for the sake of bodybuilding and nutrient disposal humalog is still kinjg becaus eof the onset of the slin is quicker than humulin R as well..more like 15min rather than 30min, especially when there is such a short window of recovery for the muscles.

[TexasFitnessGirl]

Your correct in saying that the slower acting slin effects your BG levels to a lesser degree ( hypo ) but you have toi take into consideration that using the slower or longer acting slin requires you to limit your fat intake for longer periods of time as well. I beleive this information may have been writen before humalog was on the market, so i think hunulin R is still useful especially sinse it's legal i beleive in more states than humalog is and both are legal in canada..but for the sake of bodybuilding and nutrient disposal humalog is still kinjg becaus eof the onset of the slin is quicker than humulin R as well..more like 15min rather than 30min, especially when there is such a short window of recovery for the muscles.

Thank you very much, I will put that in there. Anything else you think of let me know!

[system admin]

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[Unknown$$]

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[shadowman25]

I love the way you started the third sentence in the drug history. It flows very nice. Your article is easy to follow and your details support your topics , nice job!

[Billy_Bathgate]

what are you guys talking about IM injection

go sub-q

its absorbtion rate is much higher than IM

humalog is they way to go

would be smart as well to get a glucometer, keep blood sugar above 70-80 the best you can....below 40 is when most people i see are out of it

[TexasFitnessGirl]

what are you guys talking about IM injection

go sub-q

its absorbtion rate is much higher than IM

humalog is they way to go

would be smart as well to get a glucometer, keep blood sugar above 70-80 the best you can....below 40 is when most people i see are out of it

Thanks, I meant to put that in there with a price. Good one

[TexasFitnessGirl]

what are you guys talking about IM injection

go sub-q

its absorbtion rate is much higher than IM

humalog is they way to go

would be smart as well to get a glucometer, keep blood sugar above 70-80 the best you can....below 40 is when most people i see are out of it

I guess I am not getting the IM Injection, and Sub Q what do you mean???

[TexasFitnessGirl]

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[SportsMedVIP]

Good info. Bump for more proof reading.

[Billy_Bathgate]

IM= Intramuscular

SubQ = Subquetaneous aka under the skin

[TexasFitnessGirl]

Good info. Bump for more proof reading.

thanks we need more proofreading!

[joevette]

what are you guys talking about IM injection

go sub-q

its absorbtion rate is much higher than IM

humalog is they way to go

would be smart as well to get a glucometer, keep blood sugar above 70-80 the best you can....below 40 is when most people i see are out of it

How do you figure, BB? With an IM slin injection its absorbed in half the time. Did you ever see Einstein1905's excel plot before he got banned? It clearly showed that IM slin is in and out in half the time of Subq.

[DEVLDOG]

How do you figure, BB? With an IM slin injection its absorbed in half the time. Did you ever see Einstein1905's excel plot before he got banned? It clearly showed that IM slin is in and out in half the time of Subq.

i was gonna as the same question

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[TexasFitnessGirl]

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[TexasFitnessGirl]

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[Mallet]

The onset of activity is much quicker with IM than with subQ..I have tried both ways and there is no comparison, another added benefit to going IM is that injections near a muscle that you have worked can dramatically increase the absorption rate and effect of your dose of slin. We could also add things like Chromium, ginseng, ALA, cinnamon all increase insulin sensativity.

[Billy_Bathgate]

How do you figure, BB? With an IM slin injection its absorbed in half the time. Did you ever see Einstein1905's excel plot before he got banned? It clearly showed that IM slin is in and out in half the time of Subq.

open up a PDR. they have it plotted precisely.

[Billy_Bathgate]

actually, i double checked and this is how it is...maybe ill scan the page later if anyone is interested that much

but there is a comparison of IV, IM, and SubQ

IV is very rapid and off the chart obviously

IM initially, has plasma concentrations higher and sharper than subQsubQ maximum, and even then its a fairly fine line

However, the biggest observation, is that the peak blood plasma concentration IS achieved with SubQ, not IM


The graphs are nearly identical, but higher levels are achieved with SubQ


PDR 2002 Ed. 56

[TexasFitnessGirl]

actually, i double checked and this is how it is...maybe ill scan the page later if anyone is interested that much

but there is a comparison of IV, IM, and SubQ

IV is very rapid and off the chart obviously

IM initially, has plasma concentrations higher and sharper than subQsubQ maximum, and even then its a fairly fine line

However, the biggest observation, is that the peak blood plasma concentration IS achieved with SubQ, not IM


The graphs are nearly identical, but higher levels are achieved with SubQ


PDR 2002 Ed. 56

Good info thanks!

[TexasFitnessGirl]

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[metallicafan4u69]

Too much to read...sorry

[TexasFitnessGirl]

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[angelxterminator]

yea billy is right. Prior to popular belief highest blood plasma levels are achieved sub-q as compared to IM.. Obviously IV is the highest, but that is another story!

Either way IM onset is still faster. And this information in the pdr is also biased and incorrect in some examples!
One example of this would be if you were to inject something fat soluble, obviously onset if injected sub-q would be much much slower than the alternatives!
There are many more factors to consider when actually administering your injections than what they did when the graph was plotted. That is just a general guideline, and is in no way precise to what we are doing!

[angelxterminator]

i believe jyzza and i had this same conversation in a thread about a week ago, i think he posted the graph also!