Tren / 5AR blockers / Hairloss?????

[Duke of Earl]

Anyone got any info / experiences with tren hairloss & finasteride / dutasteride??
Tren is not DHT based so it should be metabolised by 5AR to a DHT derivative...............does anyone know if it's these 5AR metabolites or the tren itself that's responsible for hairloss??

[hill8985]

From what I have read trenbolone does not appear to undergo 5-alpha reduction in humans. As such, it does not display the strong anabolic /androgenic dissociation noted with nandrolene. It retains the same amount of potency when entering cells of various androgen target tissues as it doesn when entering muscle tissues, and does not get any weaker. This makes tren far more androgenic in appearance. The induction of double bonds at c9 and c11 seem to increase the androgen receptor binding. This represents a reason that trenbolone's potency is increased. Side effects like acne,body/facial hair growth and HAIR LOSS are therefore all possible during use of trenbolone.


info from
Disposition of 17 beta Trenbolone in humans. Spranger,Metzler. J Chromatogr 564(1991) 485-92

[Duke of Earl]

Hmmmm...... so this would suggest that finasteride / dutasteride would be of no use in reducing tren induced hairloss?
Do you think topical spiro would be of any use (competing with / blocking androgen receptors in the scalp)??
Also is topical spiro be effective against winny induced hairloss? It should be in theory....?

[BajanBastard]

5-a-blocker are useless against tren . Get something topical.

[soo2bhuge]

so the question is will anything slow down or stop tren hairloss

bump

[Duke of Earl]

big K.L.G

5-a-blocker are useless against tren. Get something topical.

any more info / research on this?

[BajanBastard]

Anyone got any info / experiences with tren hairloss & finasteride / dutasteride??
Tren is not DHT based so it should be metabolised by 5AR to a DHT derivative...............does anyone know if it's these 5AR metabolites or the tren itself that's responsible for hairloss??

Ok let me clear this up as best as i can.

Trenbolones' chemical make-up makes it resistant to the 5-a-reductase enzyme. Trenbolone ITSELF is highly androgenic so it causes hair loss on its own. Funny thing is when i was doing the profile on tren i found that one of trens metabolites was still highly active with a strong binding to the A.R........however it does not bind as well to 5-a-r tissues (scalp, prostate)

[hill8985]

ok so i will be bold

http://www.hairclub.com/

nice

[Duke of Earl]

[QUOTE]i found that one of trens metabolites was still highly active with a strong binding to the A.R........however it does not bind as well to 5-a-r tissues[QUOTE]

Hmmmmmmmmm sounds very intersesting.....Any more info (on what this metabolite is?)

Also - I've got a load of topical spiro, but haven't really felt the need to use it - has anyone used it alone? or with tren ? Just interested whether it really works????????

[promiscio]

anyone have any more info on this? What do you take to prevent hairloss on Tren ? Or slow it?

[Duke of Earl]

anyone have any more info on this? What do you take to prevent hairloss on Tren? Or slow it?

topical spiro