estrogen and igf-1

[PunkRawk]

estrogen plays an important role in the body from what i read...it has something to do with the release of igf-1.....the question is how much estro should be blocked on a mass cycle of over 1 or 2 g's of test...blocking estro with arimidex or proviron seems block the release of igf-1.....so i am wondering if using clomid as a mild anti-e and then arimidex ever 5 days or so would be smart....there has to be a ratio to figure out how much estro we need in our bodies??

[Dr.Evil]

that´s a good question, but i don´t know if there´s ever been a documented study to answer your question.

[PunkRawk]

well i figured you might know this....lets look it from this angle maybe the two of us and can up with some sort of hypthosis....supposedly nolvadex can kill igf-1 production by up to 24% in people.....nolvadex is a pretty weak anti-e compared to arimidex ....arimidex stops the conversion completely right?? nolva just binds to the receptors....so my train of thought is that arimidex might kill igf-1 completely....and if it does then how are people growing off large mass cycles?? or are they not?? clomid is a synthetic e that has no estrogen like values....it binds to the receptors so that "real" estro can't....i dunno...this is all so confusing...i want the best mass i can get without hindering things due to water retention...seems like 25mg's proviron ed or eod and clomid eod during a cycle might be good and if signs of gyno pop up then hit it hard with arimidex or nolva....

PUNKRAWK

[Dr.Evil]

but if less estrogen means less igf-1 then women should have much more igf-1 than men. the mechanism may not be estrogen mediated or estrogen receptor mediated.

[PunkRawk]

wait i think i read this somewhere....progesterone and igf-1 work together in the female body....i need to go dig up some info...

[TxLonghorn]

Well, I may have this mis-remembered, but arimidex won't lower igf-1 as much as nolva. In fact, I seem to recall reading that nolva could lower igf-1 levels by ~58%, clomid ~31%, and arimidex ~18%.

Letrozole , which is the next generation anti-e will actually increase igf-1 levels.

What I would like to know is the whole fina/gyno issue. Is it prolactin, igf-1, WHAT?

[D00fy]

hope this helps u

http://www.anabolicreview.com/vbulle...threadid=15226