tamoxifen sides?

[poshjoss]

Tamoxifen , what is it made from.? Is it at all toxic.? Will the body increase eostrogen to counteract the blockade.? How can the excess eostrogen be metabolized faster when blocked.? Calcium d-glucarate? indole 3-carbinol?

[shortie]

Anabolic Review Profile: Nolvadex (Tamoxifen Citrate) No-No-None to metabolize-WTF?-WTF? See profile for clarification.

[poshjoss]

I have read the profile. It did not answer these questions. Hence the thread. I really don't mind if no- one else has bothered to check these things, but why bother posting if you do not no the answers.

[shortie]

I have read the profile. It did not answer these questions. Hence the thread. I really don't mind if no- one else has bothered to check these things, but why bother posting if you do not no the answers.

I did answer your questions-In order but with less detail, Is it at all toxic.? No, it is not toxic(actually it is, but very negligible, I mean after all they do give it to women at several times the doses we use for years on end).Will the body increase eostrogen to counteract the blockade.? No, there is no estrogen rebound in response to nolva, remember, your body thinks it is estrogen, if anything it will downgrade production.How can the excess eostrogen be metabolized faster when blocked.?-answered by previous question. Calcium d-glucarate? indole 3-carbinol? I do not know what you are asking here. Are you asking what it is made of-Might I suggest the profile again as it has the exact chemical name listed. Tamoxifen citrate.

Sorry if I do not wish to type all day answering questions you could answer in 20 seconds by using the search engine.

[magic32]

Sorry if I do not wish to type all day answering questions you could answer in 20 seconds by using the search engine.

M.

[Wanderlei Silva]

I've never noticed any side affects on Nolva.

[Swifto]

I've never noticed any side affects on Nolva.

Same here. I have seen blurred vision been reported. Though, very, very rare.

[T3/T4 GSR]

That is a side effect I usually see reported from clomid.

[Swifto]

That is a side effect I usually see reported from clomid.

True. I have also seen this with Tamoxifen Citrate's use.

[shortie]

I have read a few posts regarding vision distortion and Nolva, generally at very high doses(80mg ed+), and there is one around here by a former mod about his vision permanently altered by nolva use, low dose. But after searching online several med journals I can find no scientific study regarding this side effect.

[Swifto]

I have read a few posts regarding vision distortion and Nolva, generally at very high doses(8mg ed+), and there is one around here by a former mod about his vision permanently altered by nolva use, low dose. But after searching online several med journals I can find no scientific study regarding this side effect.

Same here. I dont take Clomid due to the vision disturbences it occassionally brings. I'm blind in my right eye, so vison blurriness will REALLY effect me. I use Nolva during PCT, however. I've found that these sides are so rare with Tamoxifens use, I use it during PCT and if gyno signs appear.

[poshjoss]

Sorry mate, not trying to suggest that you are only around to answer my questions. The compounds Indole-3-carbinol & Calcium-d-glucarate are found in a couple of products by a vitiamin and mineral company called biocare. Biocare are not involved in any aspect of sports nutrition. I think I am right in saying that eostogen is an adreno-cortico steroid hormone, thus it will be metabolized, and either excreted or the componants re-entered into the adreno- cortico hormone cycle. Nolvadex is a SERM, which I think means that eostrogen will be selectively blocked from affecting certain tissue types. Great. If I am getting anything wrong please correct me as I do not wish to continue with wrong info. However this still leaves an amount of eostrogen floating around the body with no where to go. This at some point, is apparently able to convert into a bad eostrogen, which is worse than the regular kind, a possible carcinogen.... need I say more, and has even worse side effects Indol and gluc are meant to prevent this conversion and to help eliminate what they cannot save. I assume that the suppression of eostrogen would be less favourable than allowing the eostrogen to be reconverted into its base componants and re-used in the bodies natural hormone cycle.
So, how do you make a hormone?
Don't pay her.....

[shortie]

Actually, estrogen is predominantly a sex hormone, with the vast majority produced in the sexual organs. A very small amount is produced in the Adrenal glands, so you will find it listed both as and adrenocortical steroid and as a sex hormone. You are correct in how the nolva will interact with the estrogen, in that it does block it form attatching to the estrogen receptors and Nolva has a very high affinity for binding with th eR in breast tissue. Nolva does not however reduce the amount of estrogen in the body, as you said, merely block is from activating a receptor site. It is important to say that estrogen in the male body is needed for a healthy body and active muscle growth, but excess estrogen does have negative side effects, short term being water retention(bloat), gynecomastia , decreased sex drive, and increased fat retention. When cycling the primary concerns would be water retention and gyno, the others will be moderated by the additional androgens taken in during cycle. Nolva will do nothing for bloat, it just won't, it simply does not lower estrogen and excess estrogen will make you retain H20, but it works wonders on gyno due to it's aforementioned affinity for breast tissue. So you can see that short term raised estrogen levels are limited in nature and effect easily moderated by a SERM or AI. Long term effects can be much more serious though, long term excess estrogen has been linked to heart disease(odd since correct levels are heart healthy), diabetes, and yes some cancers. To help you body metabolize some of the estrogen there are several steps one can take;

By, Rick Cohen, M.D

1) Lose weight. Fat cells, especially in the abdominal region, produce the aromatase enzyme, which converts testosterone into estrogen.

(2) Reduce or eliminate alcohol consumption to enable your liver to better remove excess estrogens.

(3) Get 80-90 mg a day of zinc. Zinc functions as an aromatase inhibitor for some men.

(4) Increase the amount of cruciferous vegetables such as broccoli and cauliflower and flax these promote the liver to metabolize and excrete excess estrogen Taking milk thisle or a liver supplement, such as liv 52 would help with this also

(5) Reduce or eliminate and medications that you are regularly taking that may interfere with your healthy liver function. Common medications include NSAIDs (e.g. ibuprofen, acetaminophen, aspirin), the "statin" class of cholesterol lowering drugs, some heart and blood pressure medications, and some anti-depressants.


Edit, just looked these up:Indole-3-carbinol-Taken from milk thistle. Calcium-d-glucarate-Taken from powdered broccoli. Both are natural elements that simply improve liver function


A little clip and paste, some of my own thinking, hope it helps~

[poshjoss]

Right, I think that explains everything. Shortie you have been patient and helpful. Much appreciated. Tyhankyou.

[shortie]

Right, I think that explains everything. Shortie you have been patient and helpful. Much appreciated. Tyhankyou.

Glad to help, sorry if I was kind of dick the other day. We get too many around here who just want the answer and not the why/how so my answers are sometimes a bit short.

[speak]

Good to see some love around here

Seems like tempers have been running high.