The truth on Ibuprophen??

[cache49]

This is posted on the diet board as well, so i appoligise to those who read it twice. There seems to be ment differing opinions on this topic, id like to se what u guys think. How does the use of ibuprophen affect muscle gain, if at all?? Thanx.

[Dizz28]

Neither drug had any influence on whole body protein breakdown, as
measured by rate of phenylalanine appearance, on serum
creatine kinase, or on rating of perceived muscle soreness
compared with PLA. These results suggest that over-thecounter
doses of both ibuprofen and acetaminophen suppress
the protein synthesis response in skeletal muscle after eccentric
resistance exercise

Ibuprofen and acetaminophen are purported to relieve
muscle soreness and pain through separate mechanisms.
Ibuprofen is known to block cyclooxgenase (EC
1.14.99.1), which then reduces metabolites produced by
this enzyme, such as prostaglandins, that are at least
partially responsible for inflammation and algesia (14,
35, 36). However, prostaglandins have also been shown
to regulate protein metabolism, and NSAIDs similar to
ibuprofen have been shown to blunt protein metabolism
in animal skeletal muscle (24, 30). Therefore,
skeletal muscle protein metabolism may be influenced
in individuals who consume ibuprofen after unaccustomed
exercise. The mechanism of analgesic action of
acetaminophen, also known as paracetamol, is less
clear; however, it is believed to have its analgesic
action within the central nervous system (8, 11, 15, 32,
36). Thus acetaminophen would not be expected to
interfere with muscle protein metabolism after exercise.

......However, long-term use of
these drugs may inhibit the normal hypertrophic response
to resistance training. Future studies on the
impact of chronic consumption of over-the-counter
doses of these drugs on skeletal muscle are warranted.


All taken from this study...

http://209.85.165.104/search?q=cache...lnk&cd=1&gl=us

[Dizz28]

In other words, even an OTC dose of Ibu can have an effect on muscle mass gain. It doesn't cause muscles to break down like Thyroid hormones or some cortico steroids but it will have an effect on protien synthesis to rebuild muscles after exercise.

[cache49]

Thanx diz, good factually based awnser. In the garbage with the Motrin it is.

[Dizz28]

Thanx diz, good factually based awnser. In the garbage with the Motrin it is.

It has it's uses, i just wouldn't take it too much while trying to build.

Anyway, remember that Motrin and Naproxen are a little ruff on the liver to metabolize so you wouldn't want to take them while on an oral AAS for that reason either

[YouAintKnow330]

Good Read

[cache49]

I wasnt aware of that negative affect on the liver. AAs are bad enough, i dont want any undue stress. Thanx

[AandF6969]

Wrong forum