Gear and Prostate Issues

[stitch1967]

I've recently started Primo/Prop cycle. (3wks ago)

Recently I've had all the symptoms of a enlarged prostate: weak stream, frequent urination, straining to piss, etc.

I've done test before with no probs, so I'm guessing its the Primo.

I am taking a Prostate Health supplement with all the recommended ingredients.

Can anyone comment on same experience? Remedies?

[meathead320]

You could get blood work and find out what your Estradiol levels are.

E2 is the biggest problem for the prostate, as most new research is showing. Not Testosterone , or even DHT.

However, testosterone and other AAS that turn into E2 CAN be causing BPH.

If you find out you are too high on a blood test (and why not have other things like lipids and RBC checked out too?), then getting that down a bit with an AI may help.

That is my .02$, but there are guys on here who know more than me too.

[stitch1967]

yes I am also running .5mg of Arimidex EOD.

[meathead320]

yes I am also running .5mg of Arimidex EOD.

Then I doubt it is E2 being too high. That is plenty.

[Kratos]

get some dutasteride, start using it when you get it
Keep using it at .5mg ed for a few months after your cycle is over
Things may not get better until your cycle is over with primo being a DHT

[stitch1967]

Thanks bro, I'll def look into it. Oops and Winny is a DHT too....I bring it up because I was thinking of throwing in 50mg/ed the last 6 weeks.

can u from research labs like AI's and such?

[stitch1967]

Found the dutast...but have another question. I just rememebered I have some Flomax at the house my doc gave me that I never used. The active ingredient is Tamsulosin HCI not dutasteride. Is there a reason that the dutasteride would be preferable?

[Kratos]

Flowmax doesn't shink your prostate, but will quickly reduce symptoms of an enlarged prostate. May work well for you well on cycle, but I think post cycle you should run the dutasteride to make an effort to reduce the swelling. Don't want to be on flowmax for life if you are a young guy.

[Kratos]

Instead of shrinking the gland, it relaxes the muscles in the prostate gland. This relives the pressure on the urethra.

here is the list of side effects which is why you might not want to be on it forever.

Men using flomax are subject to a number of flowmax side effects, however. Common side effects include dizziness, drowsiness, nausea, diarrhea, headache, backache, chest pain, cough, sore throat, sinus problems, weakness, and sexual side effects. In some men, fainting can occur. You should use caution when driving or operating heavy equipment until you know how flomax will affect you.

[Kratos]

Dutasteride is AKA avodart if you wanted to do some research on it.

[stitch1967]

Thanks bro actually I did a search and found an article where they were doing studies on both as monotherapies and then running both. Therapies with Flomax alleviated symptoms quicker but the therapies with Dutasteride alone and the flomax/dutasteride therapy actually lower PSA's significantly more. I think I will run them both until the Flomax runs out then continue with the Dutasteride as you suggested thru PCT basically.

Thanks again for the info.

Below is a couple of the articles:

"PURPOSE: We investigated whether combination therapy with dutasteride and tamsulosin is more effective than either monotherapy alone for improving symptoms and long-term outcomes in men with moderate to severe lower urinary tract symptoms and prostatic enlargement (30 cc or greater). We report preplanned 2-year analyses. MATERIALS AND METHODS: The CombAT study is an ongoing, multicenter, randomized, double-blind, parallel group study. Men 50 years or older with a clinical diagnosis of benign prostatic hyperplasia, International Prostate Symptom Score 12 points or greater, prostate volume 30 cc or greater, total serum prostate specific antigen 1.5 ng/ml or greater to 10 ng/ml or less and peak urinary flow greater than 5 to 15 ml per second or less with a minimum voided volume of 125 ml or greater were randomized to 0.5 mg dutasteride, 0.4 mg tamsulosin or the combination once daily for 4 years. Symptoms were assessed every 3 months and peak urinary flow was assessed every 6 months. The primary end point at 2 years was the change in International Prostate Symptom Score from baseline. RESULTS: Combination therapy resulted in significantly greater improvements in symptoms vs dutasteride from month 3 and tamsulosin from month 9, and in benign prostatic hyperplasia related health status from months 3 and 12, respectively. There was a significantly greater improvement from baseline in peak urinary flow for combination therapy vs dutasteride and tamsulosin monotherapies from month 6. There was a significant increase in drug related adverse events with combination therapy vs monotherapies, although most did not result in the cessation of therapy. CONCLUSIONS: In men with moderate to severe lower urinary tract symptoms and prostate enlargement (30 cc or greater) combination therapy provides a significantly greater degree of benefit than tamsulosin or dutasteride monotherapy."

Another from Uro Today:

Objectives: The ongoing CombAT study is investigating whether combination therapy with dutasteride and tamsulosin is more effective than either monotherapy alone for improvement of symptoms and long-term clinical outcomes of AUR and BPH-related prostatic surgery in a population of men aged ≥50 years with moderate-to-severe BPH symptoms and prostatic enlargement. Results of pre-planned 2-year interim safety and tolerability analyses are reported. Materials and

Methods: The study is a multicenter, randomised, double-blind, parallel-group study. Eligible subjects were men aged ≥50 years with a clinical diagnosis of BPH, an IPSS ≥12 points, a prostate volume ≥30 cc by TRUS, a total serum PSA 1.5-10 ng/mL, and a Qmax <5 mL/sec and ≤15 mL/ sec with a minimum voided volume ≥125 mL. Subjects were randomised after a 4-week placebo run-in period to dutasteride 0.5 mg, tamsulosin 0.4 mg, or the combination once daily for 4 years. Adverse events and vital signs were recorded at every 3-month visit; PSA and laboratory tests at screening and annually. TRUS-guided prostate biopsies were conducted at the investigators' discretion.

Results: A similar proportion of patients in each treatment group reported adverse events (Table). No statistically significant differences were observed for combination versus either monotherapy in clinical laboratory or vital sign thresholds, or DRE changes. Prostate cancer was reported in 21, 11 and 26 men in the combination, dutasteride and tamsulosin groups. PSA decreased by a median of 56.0% and 55.0% from baseline in the combination and dutasteride groups, and increased in the tamsulosin group by 12.1%.


Conclusions: The profile of events for combination therapy was consistent with those reported for monotherapies. Drug-related events were more common with combination therapy than monotherapies. Both tamsulosin and dutasteride have different effects on ejaculatory function: this may explain the more than additive rate observed. Rates of withdrawal due to adverse events were low in all groups.

[stitch1967]

AWW! there was a table that would not paste with more info...here's the link.

http://www.urotoday.com/287/conferen...bat_study.html

[stitch1967]

yeah, I only have a couple weeks worth of the flomax. I think I'll use it to get symptoms down then just stick with the dutasteride.