Why does it take 4-5 weeks for testosterones full effect?

**Pac Man** · 08-19-2008, 05:24 PM

I haven't been able to figure this out yet.
If you inject today by day 3-4 your levels should be at their highest from the injection, so why does it take 4-5 weeks to feel the full effects of testosterone and not just 3-4 days? I'm mostly speaking on a HRT stand point and not so much on physical appearance and strength but more on mood, drive, etc.

**DS21** · 08-19-2008, 05:28 PM

When I use prop I start to notice the wood getting harder with in a week, so I'm guessing your talking about test e, that I've never tried so don't know, but would like too.

**JiGGaMaN** · 08-19-2008, 05:33 PM

Its a mystery thats been plaguing mankind since the dawn of time. Just kidding. Only reason is the ester attached. If you were injecting, say, test suspension youd be up and going in a couple days.

**Pac Man** · 08-19-2008, 05:34 PM

Yea but even so, the half life is 8-15 days so by week 4-5 it's almost completely through your system, am I correct on this?

**JiGGaMaN** · 08-19-2008, 05:36 PM

Well yeah, assuming you only inject for the first week.

**jstraw428** · 08-19-2008, 05:37 PM

It is simply due to the ester attached to the test......suspension would be almost imediate, where as enanthate would be 3-4 wks.....unless frontloaded....

**ChemWizard1** · 08-19-2008, 05:39 PM

im guessing that the higher levels of test up-regulate the receptors as well as the genes coding for the transcription machinery necessary for making the tRNA that protein is synthesized from. Long story short the machinery builds up after a few weeks i believe

**JiGGaMaN** · 08-19-2008, 05:43 PM

Originally Posted by ChemWizard1

im guessing that the higher levels of test up-regulate the receptors as well as the genes coding for the transcription machinery necessary for making the tRNA that protein is synthesized from. Long story short the machinery builds up after a few weeks i believe

You seem like the type of guy who does things like this:

2+2=?

(((2+2(8)/2)sqrt)-1)*2=4

**DS21** · 08-19-2008, 05:51 PM

Originally Posted by JiGGaMaN

You seem like the type of guy who does things like this:

2+2=?

(((2+2(8)/2)sqrt)-1)*2=4

lol.

**nhl1** · 08-19-2008, 05:46 PM

If I understand chemwizard, and I think I do, I guess he's saying that your receptors become more susceptible to the compound as time and exposure progresses.

This must make sense, or some other explanation such as this, because I was just pondering this earlier at the gym, and it otherwise makes no sense.

The primo Im injecting has a half life of 10-14 days, so theres no reason it should take until now (60 days in) that I am feeling this HUGE increase in strength and endurance. But, the fact remains, that I am.

Its wierd, but somehow, true.

**Pac Man** · 08-19-2008, 06:01 PM

Originally Posted by ChemWizard1

im guessing that the higher levels of test up-regulate the receptors as well as the genes coding for the transcription machinery necessary for making the tRNA that protein is synthesized from. Long story short the machinery builds up after a few weeks i believe

Good answer

**LATS60** · 08-20-2008, 07:15 AM

Originally Posted by ChemWizard1

im guessing that the higher levels of test up-regulate the receptors as well as the genes coding for the transcription machinery necessary for making the tRNA that protein is synthesized from. Long story short the machinery builds up after a few weeks i believe

mRNA, and no i'm not going to post the chemistry for the process of ar to protein end product through dimer doubling and DNA to nucleus,thank god i hear you say lol.

**ChemWizard1** · 08-21-2008, 12:13 AM

Originally Posted by LATS60

mRNA, and no i'm not going to post the chemistry for the process of ar to protein end product through dimer doubling and DNA to nucleus,thank god i hear you say lol.

* mRNA, sorry for the typo. Although tRNA production machinery is also up-regulated as well since a higher rate of protein synthesis requires more free tRNA available to bring in new amino acids to the new elongating polypeptides. Glad to see we got some other science backgrounds around here bro

**ChemWizard1** · 08-19-2008, 05:52 PM

by the way I have a degree in molecular bio and chemistry.....

**ChemWizard1** · 08-19-2008, 05:56 PM

same way that Clen down regulates or certain drugs can lose effectiveness over time due to disabling or down regulating receptors...Test is obviously a *********ary necessity so your body would up regulate in times of increased testosterone ...i.e. puberty and growth which coincides with higher test production

**dece870717** · 08-19-2008, 05:58 PM

This When will my "GEAR" kick in & frontloading explained...NOW READ IT! explains a bit of why its effect is delayed.

**xXDevilDogXx** · 08-19-2008, 06:12 PM

Actually, look at it like this:

24 Injections of 250mg Test Enanthate Every 3.5 Days would be a typical 12 weeker.
So:

Day 0 : 250
Day 1 : 238.1
Day 2 : 226.19
Day 3 : 214.29
Day 4 : 446.43
Day 5 : 422.62
Day 6 : 398.81
Day 7 : 625
Day 8 : 589.29
Day 9 : 553.57
Day 10 : 517.86
Day 11 : 729.16
Day 12 : 687.5
Day 13 : 645.83
Day 14 : 854.17
Day 15 : 806.55
Day 16 : 758.93
Day 17 : 711.31
Day 18 : 910.71
Day 19 : 857.14
Day 20 : 803.57
Day 21 : 1000
Day 22 : 942.98
Day 23 : 886.46
Day 24 : 829.93
Day 25 : 1021.42
Day 26 : 961.95
Day 27 : 902.48
Day 28 : 1093
Day 29 : 1030.07
Day 30 : 967.65
Day 31 : 905.22
Day 32 : 1091.54
Day 33 : 1027.64
Day 34 : 963.74
Day 35 : 1149.83
Day 36 : 1083.95
Day 37 : 1018.58
Day 38 : 953.19
Day 39 : 1136.57
Day 40 : 1069.71
Day 41 : 1002.86
Day 42 : 1186
Day 43 : 1118.38
Day 44 : 1050.77
Day 45 : 983.14
Day 46 : 1165.14
Day 47 : 1096.76
Day 48 : 1028.39
Day 49 : 1210
Day 50 : 1140.85
Day 51 : 1071.72
Day 52 : 1002.57
Day 53 : 1183.24
Day 54 : 1113.71
Day 55 : 1044.2
Day 56 : 1224.67
Day 57 : 1154.76
Day 58 : 1084.86
Day 59 : 1014.95
Day 60 : 1194.86
Day 61 : 1124.57
Day 62 : 1054.29
Day 63 : 1234
Day 64 : 1163.52
Day 65 : 1093.05
Day 66 : 1022.57
Day 67 : 1202
Day 68 : 1131.33
Day 69 : 1060.67
Day 70 : 1240
Day 71 : 1169.14
Day 72 : 1098.29
Day 73 : 1027.43
Day 74 : 1206.52
Day 75 : 1135.57
Day 76 : 1064.62
Day 77 : 1243.67
Day 78 : 1172.61
Day 79 : 1101.58
Day 80 : 1030.52
Day 81 : 1209.43
Day 82 : 1138.28
Day 83 : 1067.15
Day 84 : 996

This is figuring in the half life and the amount of days until your body reaches a stable dose that doesn't change much. Basically you have reached peak blood levels. For the sake of this sample Test E cycle, it is around day 21. Or at least 3 weeks in.

For cypionate , you are looking at around day 32.
For propionate , you are looking at around day 8.
For undeconoate, you are looking at around day 21.

Interesting? Yeah.

**wukillabee** · 08-19-2008, 06:42 PM

Originally Posted by xXDevilDogXx

Actually, look at it like this:

24 Injections of 250mg Test Enanthate Every 3.5 Days would be a typical 12 weeker.
So:

Day 0 : 250
Day 1 : 238.1
Day 2 : 226.19
Day 3 : 214.29
Day 4 : 446.43
Day 5 : 422.62
Day 6 : 398.81
Day 7 : 625
Day 8 : 589.29
Day 9 : 553.57
Day 10 : 517.86
Day 11 : 729.16
Day 12 : 687.5
Day 13 : 645.83
Day 14 : 854.17
Day 15 : 806.55
Day 16 : 758.93
Day 17 : 711.31
Day 18 : 910.71
Day 19 : 857.14
Day 20 : 803.57
Day 21 : 1000
Day 22 : 942.98
Day 23 : 886.46
Day 24 : 829.93
Day 25 : 1021.42
Day 26 : 961.95
Day 27 : 902.48
Day 28 : 1093
Day 29 : 1030.07
Day 30 : 967.65
Day 31 : 905.22
Day 32 : 1091.54
Day 33 : 1027.64
Day 34 : 963.74
Day 35 : 1149.83
Day 36 : 1083.95
Day 37 : 1018.58
Day 38 : 953.19
Day 39 : 1136.57
Day 40 : 1069.71
Day 41 : 1002.86
Day 42 : 1186
Day 43 : 1118.38
Day 44 : 1050.77
Day 45 : 983.14
Day 46 : 1165.14
Day 47 : 1096.76
Day 48 : 1028.39
Day 49 : 1210
Day 50 : 1140.85
Day 51 : 1071.72
Day 52 : 1002.57
Day 53 : 1183.24
Day 54 : 1113.71
Day 55 : 1044.2
Day 56 : 1224.67
Day 57 : 1154.76
Day 58 : 1084.86
Day 59 : 1014.95
Day 60 : 1194.86
Day 61 : 1124.57
Day 62 : 1054.29
Day 63 : 1234
Day 64 : 1163.52
Day 65 : 1093.05
Day 66 : 1022.57
Day 67 : 1202
Day 68 : 1131.33
Day 69 : 1060.67
Day 70 : 1240
Day 71 : 1169.14
Day 72 : 1098.29
Day 73 : 1027.43
Day 74 : 1206.52
Day 75 : 1135.57
Day 76 : 1064.62
Day 77 : 1243.67
Day 78 : 1172.61
Day 79 : 1101.58
Day 80 : 1030.52
Day 81 : 1209.43
Day 82 : 1138.28
Day 83 : 1067.15
Day 84 : 996

This is figuring in the half life and the amount of days until your body reaches a stable dose that doesn't change much. Basically you have reached peak blood levels. For the sake of this sample Test E cycle, it is around day 21. Or at least 3 weeks in.

For cypionate , you are looking at around day 32.
For propionate , you are looking at around day 8.
For undeconoate, you are looking at around day 21.

Interesting? Yeah.

Well im on week 3 day 2 of test e shoot every 3.5 days for a total of 500mg for 12 weeks total. Havent noticed anything yet, no sides, no real increase in libido, no strength gains, not even water retention. From this chart i should be almost at my peak, if this is my peak with no results then this sucks. My gear is a legit ugl so thats not a problem.

***ANABOLIC SUPERMAN*** · 08-19-2008, 06:51 PM

Originally Posted by wukillabee

Well im on week 3 day 2 of test e shoot every 3.5 days for a total of 500mg for 12 weeks total. Havent noticed anything yet, no sides, no real increase in libido, no strength gains, not even water retention. From this chart i should be almost at my peak, if this is my peak with no results then this sucks. My gear is a legit ugl so thats not a problem.

Wtf is a legit ugl?

**wukillabee** · 08-19-2008, 06:57 PM

Originally Posted by bigbigt

Wtf is a legit ugl?

HAha, good point. Its a good local ugl that many use around here. Just made kinda thick with a nice little sting. Just wondering why week 3 and really nothing yet. Am i just gonna wake up one day in week 4 or 5 and be like superman with wood, strength gains, and water retention? DIet and training is in check as well as sleeping 8hrs each night.

***ANABOLIC SUPERMAN*** · 08-19-2008, 07:00 PM

Originally Posted by wukillabee

HAha, good point. Its a good local ugl that many use around here. Just made kinda thick with a nice little sting. Just wondering why week 3 and really nothing yet. Am i just gonna wake up one day in week 4 or 5 and be like superman with wood, strength gains, and water retention? DIet and training is in check as well as sleeping 8hrs each night.

Week 4-6 is normal for it to kick in so be patient bro. Keep up the training and diet.

**xXDevilDogXx** · 08-20-2008, 06:25 AM

Originally Posted by wukillabee

Well im on week 3 day 2 of test e shoot every 3.5 days for a total of 500mg for 12 weeks total. Havent noticed anything yet, no sides, no real increase in libido, no strength gains, not even water retention. From this chart i should be almost at my peak, if this is my peak with no results then this sucks. My gear is a legit ugl so thats not a problem.

No biggie, this is all 'in theory' and won't be the same for everyone. Remember, all I did was calculate exo test levels. This doesn't account for SHBG and the like.

Just be patient, it'll kick in. Test E usually takes me about 4 weeks and Cyp takes about 6 for me. Some people are different.

Let us know when it's in full swing!

**XNathan** · 08-20-2008, 07:09 AM

I simply dont understand you in this matter.

If I inject testosteron enanthate I will gain weight in first week and in second my libido is huge and I began to experience gyno when my dose is up 300mg/wk.

I gain weight in first 4-6wks and strenght I feel since 3-4wk. I allways realise that you are speaking about kick in just in metter fo strenght and better workout. But you guys from overseas are speaking about all effects.

This is my observation from test E dose 500mg/wk
1wk bloat +4-6lbs
2wk another weight 2-4lbs, elevated mood and agravated anxiety, libido boost
3wk weight another 2-4lbs, low increase in strenght, libido is huge, elevated mood and less anxiety, need AI for gyno
4wk +2-4lbs, moderate strenght gain, still good mood, high libido, normal level of anxiety
5-6wk +1-3lbs, strenght gain more than noticable all like before
7-8wk 1-2lbs lower strenght gain, lover but still high libido, normal mood
9-10wk no weight gain, low strenght gain little higher libido than normal

and end of cycle and PCT.

And testosteorne enanthate dont have half-life 10-15days!!! Its active life! So real half-life is shorter...

**LATS60** · 08-20-2008, 07:19 AM

Originally Posted by xXDevilDogXx

Actually, look at it like this:

24 Injections of 250mg Test Enanthate Every 3.5 Days would be a typical 12 weeker.
So:

Day 0 : 250
Day 1 : 238.1
Day 2 : 226.19
Day 3 : 214.29
Day 4 : 446.43
Day 5 : 422.62
Day 6 : 398.81
Day 7 : 625
Day 8 : 589.29
Day 9 : 553.57
Day 10 : 517.86
Day 11 : 729.16
Day 12 : 687.5
Day 13 : 645.83
Day 14 : 854.17
Day 15 : 806.55
Day 16 : 758.93
Day 17 : 711.31
Day 18 : 910.71
Day 19 : 857.14
Day 20 : 803.57
Day 21 : 1000
Day 22 : 942.98
Day 23 : 886.46
Day 24 : 829.93
Day 25 : 1021.42
Day 26 : 961.95
Day 27 : 902.48
Day 28 : 1093
Day 29 : 1030.07
Day 30 : 967.65
Day 31 : 905.22
Day 32 : 1091.54
Day 33 : 1027.64
Day 34 : 963.74
Day 35 : 1149.83
Day 36 : 1083.95
Day 37 : 1018.58
Day 38 : 953.19
Day 39 : 1136.57
Day 40 : 1069.71
Day 41 : 1002.86
Day 42 : 1186
Day 43 : 1118.38
Day 44 : 1050.77
Day 45 : 983.14
Day 46 : 1165.14
Day 47 : 1096.76
Day 48 : 1028.39
Day 49 : 1210
Day 50 : 1140.85
Day 51 : 1071.72
Day 52 : 1002.57
Day 53 : 1183.24
Day 54 : 1113.71
Day 55 : 1044.2
Day 56 : 1224.67
Day 57 : 1154.76
Day 58 : 1084.86
Day 59 : 1014.95
Day 60 : 1194.86
Day 61 : 1124.57
Day 62 : 1054.29
Day 63 : 1234
Day 64 : 1163.52
Day 65 : 1093.05
Day 66 : 1022.57
Day 67 : 1202
Day 68 : 1131.33
Day 69 : 1060.67
Day 70 : 1240
Day 71 : 1169.14
Day 72 : 1098.29
Day 73 : 1027.43
Day 74 : 1206.52
Day 75 : 1135.57
Day 76 : 1064.62
Day 77 : 1243.67
Day 78 : 1172.61
Day 79 : 1101.58
Day 80 : 1030.52
Day 81 : 1209.43
Day 82 : 1138.28
Day 83 : 1067.15
Day 84 : 996

This is figuring in the half life and the amount of days until your body reaches a stable dose that doesn't change much. Basically you have reached peak blood levels. For the sake of this sample Test E cycle, it is around day 21. Or at least 3 weeks in.

For cypionate , you are looking at around day 32.
For propionate , you are looking at around day 8.
For undeconoate, you are looking at around day 21.

Interesting? Yeah.

No. just very confusing, how on earth did you arrive at those figures?

**xXDevilDogXx** · 08-21-2008, 03:45 AM

Originally Posted by LATS60

No. just very confusing, how on earth did you arrive at those figures?

My numbers are very similar to these for Test E:

Originally Posted by one8nine

injection frequency
Test Injection Frequency Graphs

check that chart

**one8nine** · 08-21-2008, 10:40 AM

Originally Posted by xXDevilDogXx

My numbers are very similar to these for Test E:

i know i got your back dog ha
get it
dog

**steropower** · 08-20-2008, 05:37 AM

Wait one more week.At 500mg you could see the effect around the end of 3rd-4th week.But you should have water retention from the first week.Just wait..

**one8nine** · 08-20-2008, 10:53 AM

injection frequency
Test Injection Frequency Graphs

check that chart

**slamman119** · 08-20-2008, 05:30 PM

me im taking cyp. and its the second week. is 200a week enough.

i keep telling my buddy that supplies me that i should double it, but he said it should work fine for my first cycle.

**one8nine** · 08-20-2008, 05:39 PM

Originally Posted by slamman119

me im taking cyp. and its the second week. is 200a week enough.

i keep telling my buddy that supplies me that i should double it, but he said it should work fine for my first cycle.

lets do some math
actual test produced naturall is between 10mg-15mg daily
this breaks down to 70mg-105mg actual test naturally
100% testosterone cypionate = 70% testosterone + 30% cypionate
so 200mg of test c breaks down to 140mg actual testosterone
so this cycle wont do much more than you can do naturally

**XNathan** · 08-21-2008, 12:00 AM

Originally Posted by one8nine

lets do some math
actual test produced naturall is between 10mg-15mg daily
this breaks down to 70mg-105mg actual test naturally
100% testosterone cypionate = 70% testosterone + 30% cypionate
so 200mg of test c breaks down to 140mg actual testosterone
so this cycle wont do much more than you can do naturally

10-15mg??? Wow man! This amount have gifted ones! 4-9mg is right amount. You produce 28-63mg test/wk. By your numbers everyone schould have test level in blood 807ng/dl to 1211ng/dl and this is simply untrue

So 200mg/wk is good dose to see results in most cases.

**one8nine** · 08-21-2008, 10:39 AM

Originally Posted by XNathan

10-15mg??? Wow man! This amount have gifted ones! 4-9mg is right amount. You produce 28-63mg test/wk. By your numbers everyone schould have test level in blood 807ng/dl to 1211ng/dl and this is simply untrue

So 200mg/wk is good dose to see results in most cases.

im talking about young people youre right for old people though

**TranscriptionFactor** · 08-21-2008, 02:14 AM

The pharmokinetics of the blood plasma levels of the drug is one thing, but the drug in question is an anabolic steroid . As is alluded to above, the mechanism of action of anabolics is to enter into the cell nucleus and upregulate transcription of mRNA and hence proteins. This is a process which is not instantaneous. We're not talking about a pyschoactive substance say like valium which has a more direct mechanism of interacting with cell surface receptors and changing ion gradients. Transcription and translation (making new proteins) takes time.

**ChemWizard1** · 08-21-2008, 02:30 AM

Originally Posted by TranscriptionFactor

The pharmokinetics of the blood plasma levels of the drug is one thing, but the drug in question is an anabolic steroid. As is alluded to above, the mechanism of action of anabolics is to enter into the cell nucleus and upregulate transcription of mRNA and hence proteins. This is a process which is not instantaneous. We're not talking about a pyschoactive substance say like valium which has a more direct mechanism of interacting with cell surface receptors and changing ion gradients. Transcription and translation (making new proteins) takes time.

TF- you an Aquatic/Marine Bio major by any chance...."Way down below the sea". Good form

**TranscriptionFactor** · 08-21-2008, 02:59 AM

nah...just have a bit of medical/biochem knowledge.

I like diving. Had that song Atlantis by Donovan in my head since a lot of us here are from mythical places.