T3, risky business?

[mad103]

How true or false is it that T3 will mess up/destroy your natural thyroid function? Looking to cycle it with clen but have held back because of the possible risk of T3.

[D7M]

properly cycling t3 won't permanently damage your thyroid.

but I wouldn't recommend t3 without AAS

[*RAGE*]

properly cycling t3 won't permanently damage your thyroid.

but I wouldn't recommend t3 without AAS

agreed, I should just attach that to your post,,,,,



Prone agrees...

[powerliftmike]

post t3 cycle we definently observe a crash and rebound period in terms of thyroid function. I dont see any evidence were it's permanently suppressed tho.

[M302_Imola]

post t3 cycle we definently observe a crash and rebound period in terms of thyroid function. I dont see any evidence were it's permanently suppressed tho.

even at a low dose of say 25mcg for a short duration (4-6 weeks)?

[mad103]

what is AAS? Will there be any need for a post cycle treatment? Or how will your thyroid go back to normal after getting off of T3?

[Phate]

post t3 cycle we definently observe a crash and rebound period in terms of thyroid function. I dont see any evidence were it's permanently suppressed tho.

i agree that's it's not permanently suppressed, but i don't think you would get much of a rebound effect if you used a very gradual ramp up and ramp down(at least a week ramp up and 2-3 weeks of ramping down depending on dosage)

[marcus300]

i agree that's it's not permanently suppressed, but i don't think you would get much of a rebound effect if you used a very gradual ramp up and ramp down(at least a week ramp up and 2-3 weeks of ramping down depending on dosage)

IMHO there is no need to ramp down with t3, all it does is keeps you longer suppressed, ive tried many ways and there are studies out there which point in the direction of just stopping the dosage and let your natural thyroid kick back in again. Have you tried noth ways Phate?

T3 can savage your hard earned muscle though, so taking compounds along side t3 what will keep you anabolic which will help with this issue

[Phate]

IMHO there is no need to ramp down with t3, all it does is keeps you longer suppressed, ive tried many ways and there are studies out there which point in the direction of just stopping the dosage and let your natural thyroid kick back in again. Have you tried noth ways Phate?

T3 can savage your hard earned muscle though, so taking compounds along side t3 what will keep you anabolic which will help with this issue

yes, i didn't notice much difference either way, but i couldn't get blood work either, something for me to check out in the future

[marcus300]

yes, i didn't notice much difference either way, but i couldn't get blood work either, something for me to check out in the future

Neither did I, but from how i felt and how my body responded i really feel ramping down only prolongs the recovery, might have to search some studies out

[inky-e]

Just knowing its potential harmful effects has kept me from using it...I'd rather err on the side of caution than fukk myself up. But thats just me.

[The Deuce]

So basically... from what I have learned from this thread is ... T3 works.. it's risky... but just like anything else.. right?? And not to ramp down.. just stop when you have scheduled to stop... like say you are running it for 12 weeks.. at 12 weeks... stop... right??? Am I correct in knowing this so far or am I off.. because if I am please tell me.. BECAUSE I KNOW NOTHING ABOUT T3 and I will be the first to admit it... what is the standard dosing in mcgs?? That people usually start out with??

[MuscleScience]

IMHO there is no need to ramp down with t3, all it does is keeps you longer suppressed, ive tried many ways and there are studies out there which point in the direction of just stopping the dosage and let your natural thyroid kick back in again. Have you tried noth ways Phate?

T3 can savage your hard earned muscle though, so taking compounds along side t3 what will keep you anabolic which will help with this issue

I agree with Marcus300 on this one.

I have read studies on thyroid replacement therapy and most of them seem to point to practically any dosage as being suppressive with about the same period of time to return to a euthryoid state after stopping treatment. This of course applies to someone that was already in a euthryoid state prior to treatment and was wrongly diagnosed and/or put on treatment plans.

[The Deuce]

I know I hijacked this thread but can someone PLEASE ... answer these simple Q's for me... I really don't wanna have to start my own thread.. but I will If I have to...

[Drake Hotel]

even at a low dose of say 25mcg for a short duration (4-6 weeks)?

As with steroids , even a low dose will shut you down, yes. Using 25mcg T3 ed is not a good idea as it will only establish a lower serum level than what's normal. 50mcg for a first-timer is a good dose.

So basically... from what I have learned from this thread is ... T3 works.. it's risky... but just like anything else.. right?? And not to ramp down.. just stop when you have scheduled to stop... like say you are running it for 12 weeks.. at 12 weeks... stop... right??? Am I correct in knowing this so far or am I off.. because if I am please tell me.. BECAUSE I KNOW NOTHING ABOUT T3 and I will be the first to admit it... what is the standard dosing in mcgs?? That people usually start out with??

So far so good yeah, you got it all right. 12 weeks is way too long though imo, but perhaps that was just an example Start out with 50mcg per day and see how you react. If you tolerate it you can go on for 4 weeks.

Since T3 increases not only protein synthesis but also protein breakdown, adequate protein intake is a MUST to avoid loss of muscle mass.

[The Deuce]

So far so good yeah, you got it all right. 12 weeks is way too long though imo, but perhaps that was just an example Start out with 50mcg per day and see how you react. If you tolerate it you can go on for 4 weeks.

Since T3 increases not only protein synthesis but also protein breakdown, adequate protein intake is a MUST to avoid loss of muscle mass.

Yah I was just using that as a for instance.. I dont know if I will ever run it.. I might.. if the PROS ever outweigh the CONS then yah I might give it a whirl... so 50mcg ED for 4 weeks is a good starting point??

and I am not new to the AAS world... I take in roughly 400g's of Protein per day now as it is.. 100g's from whey and 300 g's from real food.

I dunno I gots a lot more studying to do before I ever put that substance in my body I can tell ya that !!

[M302_Imola]

As with steroids, even a low dose will shut you down, yes. Using 25mcg T3 ed is not a good idea as it will only establish a lower serum level than what's normal. 50mcg for a first-timer is a good dose.

Can you elaborate on this "lower serum level" from 25mcg t3 ED? I was under the understanding that 25mcg t3 ED will slightly elevate your BMR and also aid in protein synthesis with a lot less chance of burning muscle. I understand that the body naturally produces around 25mcg of endogenous t3 but have also heard that a exogenous 25mcg t3 amount will be more effective at increasing BMR which will increase protein synthesis. Am I wrong? How effective would a 37.5mcg dose of t3 be?

[Drake Hotel]

Can you elaborate on this "lower serum level" from 25mcg t3 ED? I was under the understanding that 25mcg t3 ED will slightly elevate your BMR and also aid in protein synthesis with a lot less chance of burning muscle. I understand that the body naturally produces around 25mcg of endogenous t3 but have also heard that a exogenous 25mcg t3 amount will be more effective at increasing BMR which will increase protein synthesis. Am I wrong? How effective would a 37.5mcg dose of t3 be?

I will try to elaborate, but it's difficult for me. Really the problem is that I don't know the correct half-life for the liothyronine salt (i.e. the drug, not what's endogenously produced). I have seen figures ranging from 1hr to 24hrs, so it all becomes difficult. But let's consider the endogenous production first. A healthy male produces about 37.5mcg T3 daily, i.e. 1.5 pill of Cytomel . Assuming that Cytomel has the same active-life as endogenously produced T3, you can see that taking only 25mcg or two thirds of what you produce yourself, will only 1) depress your own production, and 2) establish a lower serum level. If the active-life of Cytomel is longer than that of endogenous T3, then of course there might not be a problem with using only 25mcg daily.

I should add also that, at first, basically any dose of Cytomel will increase BMR, as it takes some time for endogenous production to be suppressed. I've used 25mcg before powerlifting meets and achieved effect; it kinda becomes 37.5+25mcg in that case. Not exactly of course, but you understand the principle.

Excuse me for this poorly written wall of text, but I think you can gain something from it at least. If not, simply ask more questions and I'll try to answer better I think it's interesting what you mention about Cytomel potentially having greater effect on BMR than an equal dose of endogenous T3. I've never heard of it before but it's certainly interesting.

Oh btw, on wikipedia it says that the half-life of Cytomel is 2.5 days!

[bjpennnn]

so does taking t4 suppress your t3 levels?

[M302_Imola]

I will try to elaborate, but it's difficult for me. Really the problem is that I don't know the correct half-life for the liothyronine salt (i.e. the drug, not what's endogenously produced). I have seen figures ranging from 1hr to 24hrs, so it all becomes difficult. But let's consider the endogenous production first. A healthy male produces about 37.5mcg T3 daily, i.e. 1.5 pill of Cytomel . Assuming that Cytomel has the same active-life as endogenously produced T3, you can see that taking only 25mcg or two thirds of what you produce yourself, will only 1) depress your own production, and 2) establish a lower serum level. If the active-life of Cytomel is longer than that of endogenous T3, then of course there might not be a problem with using only 25mcg daily.

I should add also that, at first, basically any dose of Cytomel will increase BMR, as it takes some time for endogenous production to be suppressed. I've used 25mcg before powerlifting meets and achieved effect; it kinda becomes 37.5+25mcg in that case. Not exactly of course, but you understand the principle.

Excuse me for this poorly written wall of text, but I think you can gain something from it at least. If not, simply ask more questions and I'll try to answer better I think it's interesting what you mention about Cytomel potentially having greater effect on BMR than an equal dose of endogenous T3. I've never heard of it before but it's certainly interesting.

Oh btw, on wikipedia it says that the half-life of Cytomel is 2.5 days!

Thanks for the reply, I did shed some light from it. As far as 25mcg exogenous being greater than 25mcg endogenous (what the body naturally makes) is due to all the different coversions that t3 goes through (t4->t3 and vice versa) when made naturally (endogenously). I have heard that it looses some of its' potency due to these conversions. Plus the replace therapy dose of t3 I believe is 25mcg. I was under the impression that the half-life of t3 is somewhere between 8-12 hours.

[M302_Imola]

so does taking t4 suppress your t3 levels?

yes t4 is converted to t3

[mad103]

so from my understanding, T3 is not much of risk if taking moderately at no more than 50mcgs. what was meant by a crash and rebound period during the post cycle? what can be done to prevent or fix it?

[The Deuce]

So it's safe to say... a first timer dose of 50mcg's daily for 4 weeks is a good start...

Saaaay... ummm...

Running Test at 250mgs EW of Enan for 12 weeks.. and the first 4 weeks of this cycle using T3 at 50mcg's is a good starting point??

would this make any sense at all to do a cycle like this to burn fat??

[Phate]

So it's safe to say... a first timer dose of 50mcg's daily for 4 weeks is a good start...

Saaaay... ummm...

Running Test at 250mgs EW of Enan for 12 weeks.. and the first 4 weeks of this cycle using T3 at 50mcg's is a good starting point??

would this make any sense at all to do a cycle like this to burn fat??

personally i think it would be better to run the t3 weeks 2-12 to give the test for best results

[The Deuce]

personally i think it would be better to run the t3 weeks 2-12 to give the test for best results

10 weeks?? of T3 ?? At 50mcgs?? Every day??


Like I said... I know nothing of this compound but I am definitely going to have to utilize it to get to where I am going to have to be to be competition ready... ya know?? FRIGGEN FAT !!! LOL

[Phate]

10 weeks?? of T3 ?? At 50mcgs?? Every day??


Like I said... I know nothing of this compound but I am definitely going to have to utilize it to get to where I am going to have to be to be competition ready... ya know?? FRIGGEN FAT !!! LOL

actually on test i would be running it up to 100-125mcg/day

[bjpennnn]

damn son cant wait for this

[kidrock29520]

personally i think it would be better to run the t3 weeks 2-12 to give the test for best results

thats way too long for cytomel if he wants to go a long route of say maybe ten weeks i'd go 5 weeks cytomel and 5 weeks clenbuterol

[M302_Imola]

actually on test i would be running it up to 100-125mcg/day

with only 250mg/week of test I think that this dose would lead to muscle wastage!

IMO it is best to start low and see how your body reacts to the compound.