Results 1 to 1 of 1
Thread: Nandolone and memory!!!!
-
04-08-2012, 09:38 AM #1
Nandolone and memory!!!!
Hi.
I have found this article on pubmed about Nandrolone and cognitive ability!
Is this true or not?
Are there any other studies that prove this or say the opposite?
http://www.ncbi.nlm.nih.gov/pubmed/18405416
Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors.
Kouvelas D, Pourzitaki C, Papazisis G, Dagklis T, Dimou K, Kraus MM.
Source
Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. [email protected]
Abstract
Anabolic androgenic steroids (AASs) affect areas of the central nervous system, which are involved in emotional and cognitive responses such as sexuality, anxiety, and memory. In the present study we imitated the abuse of AASs by administering high doses of the AAS nandrolone decanoate (ND) to rats. Thereafter rats were exposed to an elevated plus-maze and an olfactory social memory test to evaluate their anxiety-like and cognitive behaviour. To reveal whether these emotional and cognitive changes evoked by ND were caused via direct activation of androgenic receptors (ARs) in the brain, the AR antagonist flutamide (FL) was administered intracerebroventricularly (i.c.v.). Male rats were randomly divided in four groups, one group received 15 mg/kg ND subcutaneously, once daily for 6 wk (ND group). In the second group, in addition to ND, a daily dose of 5 microg FL was injected i.c.v. also for 6 wk (ND+FL group). The third group of rats received only FL and in the control group the vehicle was injected. The ND group clearly spent more time investigating the open arms in the maze test and recognizing the juvenile during the olfactory social memory test in comparison to the control group. In the ND+FL group rats showed similar emotional behaviour and cognitive ability to that of the control group. Injection of FL alone did not affect either anxiety or memory. These results indicate that repeated, high-dose administration of ND decreases anxiety and impairs memory in rats via direct activation of central ARs.
Thread Information
Users Browsing this Thread
There are currently 1 users browsing this thread. (0 members and 1 guests)
Zebol 50 - deca?
12-10-2024, 07:18 PM in ANABOLIC STEROIDS - QUESTIONS & ANSWERS