A single dose of 500mg TE impairs lipid profile by 15%

[Swifto]

US National Library of Medicine National Institutes of Health

Subst Abuse Treat Prev Policy. 2012 Mar 20;7:12.

Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase.

Gårevik N, Skogastierna C, Rane A, Ekström L.
Source

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

Abstract

BACKGROUND:

Cholesterol is mainly synthesised in liver and the rate-limiting step is the reduction of 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) to mevalonate, a reaction catalysed by HMG-CoA reductase (HMGCR). There is a comprehensive body of evidence documenting that anabolic -androgenic steroids are associated with deleterious alterations of lipid profile. In this study we investigated whether a single dose of testosterone enanthate affects the cholesterol biosynthesis and the expression of HMGCR.

METHODS:

39 healthy male volunteers were given 500 mg testosterone enanthate as single intramuscular dose of Testoviron ®--Depot. The total cholesterol levels prior to and two days after testosterone administration were analysed. Protein expression of HMGCR in whole blood was investigated by Western blotting. In order to study whether testosterone regulates the mRNA expression of HMGCR, in vitro studies were performed in a human liver cell-line (HepG2).

RESULTS:

The total cholesterol level was significantly increased 15% two days after the testosterone injection (p = 0.007). This is the first time a perturbation in the lipoprotein profile is observed after only a single dose of testosterone. Moreover, the HMGCR mRNA and protein expression was induced by testosterone in vitro and in vivo, respectively.

CONCLUSION:

Here we provide a molecular explanation how anabolic androgenic steroids may impact on the cholesterol homeostasis, i.e. via an increase of the HMGCR expression. Increasing knowledge and understanding of AAS induced side-effects is important in order to find measures for treatment and care of these abusers.

PMID:
22433938
[PubMed - in process]
PMCID:
PMC3342114

[RaginCajun]

so how would one keep there 'normal' cholesterol in the 'normal' range? lipid drugs? good read as usual swifto!

[Swifto]

So what now may you ask....

What does this mean Swifto?

It means you need to increase supplements or start such as:

CQ10
Omega 3 caps
Red Yest Rice
Niacin
EVOO
Coconut Oil
Policosonal
Nuts
Fish (salmon)
Eggs
Avacardo
Coconut milk

[Swifto]

so how would one keep there 'normal' cholesterol in the 'normal' range? lipid drugs? good read as usual swifto!

I was typing as you asked.

[RaginCajun]

thanks!

so by adding more natural fats in one's diet, it will help keep cholesterol levels down? this is good info because high cholesterol runs in my fam but mine is fine for now

[Swifto]

thanks!

so by adding more natural fats in one's diet, it will help keep cholesterol levels down? this is good info because high cholesterol runs in my fam but mine is fine for now

Yes.

Eggs, grass fed beef, raw milk, avacardos, cheeses, wild caught salmon, nuts.

[t-dogg]

Also GW-501516 seems to lower bad cholesterol. It may lower the good cholesterol also as well tho. Correct me if im wrong anyone. Im using it now, should get blood work done soon.

[RaginCajun]

Also GW-501516 seems to lower bad cholesterol. It may lower the good cholesterol also as well tho. Correct me if im wrong anyone. Im using it now, should get blood work done soon.

how do you like it so far? any results? cardio improvement?

[t-dogg]

how do you like it so far? any results? cardio improvement?

Yes and Yes. Cardio has improved alot. Also I have lost more fat. Also I feel I have more energy now. I dont take any energy drinks/supplements for the most part right now. I do 10mgs in the am, and then another 10mg's mid day. I have the liquid form right now. I will probally buy the powder form next.

[Swifto]

I believe you should get as far as you can using nutrition as your primary tool, then think about taking drugs if you need them.

[t-dogg]

I believe you should get as far as you can using nutrition as your primary tool, then think about taking drugs if you need them.

I agree 100% Swifto. Most of the food you listed is in my diet right now.

[DeadlyD]

great post swifto !! is high bad cholesterol directly linked to high blood pressure or is it just one leading factor?

[curioususer]

.........

[curioususer]

Also GW-501516 seems to lower bad cholesterol. It may lower the good cholesterol also as well tho. Correct me if im wrong anyone. Im using it now, should get blood work done soon.

i heard that stuff gives you cancer

[Atomini]

I ALWAYS run an all-inclusive lipid-support supplement while on cycle. Also plenty of EFAs and good fat sources.

[castiron]

I would like to see a placebo study where just oil was injected. I always suspected that injecting oil into your muscles would get it into your circulatory system and, well it is oil...why wouldnt cholesterol be affected. That study wasnt double blind placebo controlled and may be biased, as far as i can tell.

[Brohim]

So what now may you ask....

What does this mean Swifto?

It means you need to increase supplements or start such as:

CQ10
Omega 3 caps
Red Yest Rice
Niacin
EVOO
Coconut Oil
Policosonal
Nuts
Fish (salmon)
Eggs
Avacardo
Coconut milk

how about not injecting tons of cholesteral into your body. That is a good way not to raise your levels.

[Swifto]

I would like to see a placebo study where just oil was injected. I always suspected that injecting oil into your muscles would get it into your circulatory system and, well it is oil...why wouldnt cholesterol be affected. That study wasnt double blind placebo controlled and may be biased, as far as i can tell.

Makes no sense at all.

Thats like saying eating high fat diet, even saturated animal fat is going to cause an increase in cholesterol as the fat is going to block the walls of your arteries...

Same bullshit nutritionists, doctors and "those in the know" have been peddling for over 40 years. It nonsense and people need to wake up and read the most recent data on this subject. Fat does NOT increase cholesterol.

[DanB]

Makes no sense at all.

Thats like saying eating high fat diet, even saturated animal fat is going to cause an increase in cholesterol as the fat is going to block the walls of your arteries...

Same bullshit nutritionists, doctors and "those in the know" have been peddling for over 40 years. It nonsense and people need to wake up and read the most recent data on this subject. Fat does NOT increase cholesterol.

statins are a 20billion per year industry, (yes I said billion)

castiron google cholestrol myth and see where the theory came from and the backround it has now

[DanB]

i heard that stuff gives you cancer

if you make a statement like that you need proof to back it up

so..........????