Letro Bashing

[AnabolicBoy1981]

okay..lately i see alot of "negative" posts on letro. This post is just to give some perspective. Im not saying some of the things aren't true, but even though alot of us try not to parrot, i still think alot of us are guilty of it. Also, everybody tho all HUMAN has similar physiology, but remember we are all different. So im just gonna give my perspective on the stuff...
On PAPER, yeah it should "bottom" out e2.
Ok i have ran letro of several diff brands at up to 2.5, board sponser included, and e2 was never bottomed out.
I have ran letro for extended periods of time...7 months, 4 of which we at max dose, 2.5. Honestly, liver values were untouched, lipids were normal(and heart disease is in my family), and no my joints didnt hurt. At week 8 of the 7 month run, I had a testosterone level of 1600 and an e2 of 30
Yes, it affects penile sensitivy and can go days/weeks without spanking it or sex. The only "lethargy" i get is at night time i feel like im ready for bed and can do so without jerking off.
It kept me "bone dry" yes, but did also feel that it affected pumps, though, if i carb loaded i still filled out.
Im not saying anyone should do what i did, but bloodwork every 6 weeks on any compound will keep you from making assumptions or parroting old/new info.
Theres alot of stuff true on paper..theres alot of other user experiance....but there are things i have seen on my bloodwork on certain compounds that make absolutely no sense and in complete contradiction of litature of popular user experience.
Juuusst sayyyyin
*daily grain of salt*(dont worry its Sea Salt)

[austinite]

Clinical studies say otherwise. So does my personal experience. It's impossible for doses of milligram after milligram not to demolish your E2.

To give you an example of how low this drug is supposed to be dosed, it was studied in extremely obese hypogonadal men. Overweight men convert far more estrogen than non-overweight men. This is because they carry far more aromatase enzymes. Using Letrozole , these highly aromatizing men were treated with doses of 2mg to 2.5mg once per week. If we break that up, you're looking at about 285 micrograms per day. That's it. This powerful drug never, under any circumstances should be used in a milligram + basis on a daily administered protocol. It is simply outrageous. Reference here.

Get a prescription and you'll see exactly what I speak of.

Here's my prescription... note the dose please....



That's correct, you're not seeing things... 100 MICROgrams. 25 times LESS than the average dose that everyone on internet boards take and recommend...

So my E2 was at 47 pg/ml. On a sensitive E2 scale the recommended range is under 29 pg/ml. I needed to bring it down so I decided to go with Letro and see what happens.

I administered 100 mcg. (Micrograms) daily. After the 10th day I felt miserable and so I discontinued use. One week after I stopped, I tested E2 again and it came back 2 pg/mL. Remember, this is a full week after Letrozole was discontinued. So it had to be at zero, or "too low to count" for several days. I was bedridden for several days. Completely useless and couldn't find a reason to get up and about. If you've killed your E2 before, you know exactly what I mean. I don't wish this on anyone. Really amazes me that some folks are running this thing using milligram after milligram several times per week. And these "Gynecomastia Reversal" threads using these astronomical doses are just mind boggling. Pretty eye opening once again. Anyway, I waited a while and got back on DIM.

My dose should have been 25 micrograms and that may have saved my E2.

Here's my blood work...



Below was drawn 7 days after I discontinued Letrozole doses...




So there you have it. If letrozole is working for you... great. I will not get into chem sites, and I don't want anyone asking me questions about specific chem sites because I will ignore it. Do not attempt to put words in my mouth. But I will say, that if you're not demolishing your e2, your letro is severely underdosed. Period. No question about it whatsoever. This is not about "responding" or how your body reacts, there is no human being that will not be severely damaged by these ridiculous doses that everyone is supposedly taking. Period. We're humans, not superhumans.

With regard to gynecomastia, the idea of using Letrozole stems from a flawful study done in 2001 on mice. Not on humans. You can reference PMID 11850204 for the garbage that we've been relating to humans.

Dated: 2011 - Effects of aromatase inhibition on male breast

Tamoxifen was much more effective, however, in the prevention of gynecomastia in these men. Due to these disappointing results, aromatase inhibitors are not recommended as a first-line treatment for gynecomastia in men.

Reference the above here...

So in closing... I'll tell you that you are not using properly dosed Letrozole. And that is the reason why you are assuming you're superhuman. I assure you, you are not.

[AnabolicBoy1981]

nice post. It very well may be that letro i used was underdosed...but with letro being so strong, even if it was watered down to 1/4th or even 1/8th i would still have some of the bad sides, i would think(low libido did happen tho). I'm not saying any of your post is untrue. Im sure its all true, and probably is for 98% of humans. There are some ppl who dont respond to any drug or metabolize it faster. I agree tho, its more likely that even between several brands, they may have been underdosed. If you think about it from a chem site selling perspective, letro hands down would be the best perfect drug to cut corners with, because it does definetly have effects at pretty much any dose.