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Thread: Epinephrine? Can I just eat your adrenal gland?

  1. #1
    Frontpump is offline Associate Member
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    Epinephrine? Can I just eat your adrenal gland?

    Short version: can anybody PM me a sweet direction on how to obtain, use, or stimulate production of epinephrine? I'm familiar with using phenylalanine and nac-tyrosine for endogenous. Just wondering if there are epi-pens available on the interwebs or better methods I'm not aware of. I'm sure it's dangerous too so fill me in on that if possible.

    Long version:

    Not in med school, but I have all of my cousin's text books, and I'm reading some interesting shit. A lot of stuff I've been doing wrong.

    I've been taking arginine for over a year and a half in fairly large quantities, because of it's stated benefits. Since that time though I've not lost more than 10 pounds, in spite of eating only spinach and meat for weeks along with moderate cardio and heavy lifting. Occassional shift in muscularity, but no body fat gone.

    So then I'm reading in a bio-chem text that arginine is insulinogenic. Well ****ing duh. I remember reading somewhere how to test the purity of arginine by measuring the change in your blood sugar. (the actual tutorial was flawed, but the premise remains).

    In this same text, epiniphrine is said to be an insulin antagonist. So one defeats the other. Instead of scaring myself into low blood sugar, I'm wondering if there are effective route to this end.

    Hit me!

  2. #2
    lovbyts's Avatar
    lovbyts is offline Knowledgeable Member
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    I dont know much of anything about it but sound dangerous messing with adrenalin. Ill stick to coffee thank you.

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    You shouldn't be trying to come up with strategies based on literature that is beyond your comprehension level, since your understanding is completely backwards.

    Being insulinogenic, arginine will boost insulin without any glucose release, thus lowering your BGL. This is a good thing.

    Epinephrine does the opposite, as it stimulates adrenergic receptors in the liver, releasing more glucose into the bloodstream (part of the fight or flight response) and slows insulin release to maintain a higher BGL.

    Of course, we all know that stimulants cause weight loss, but that has nothing to do with epinephrine's effects on insulin and BGL.

    As far as increasing epi levels: caffeine and other stimulants work fine.
    You can't supplement with actual epi, since it is available by Rx only, expensive, has a 2 minute half-life, and continuous dosing would raise your heart rate and BP and quickly kill you (as well as require an IV drip).
    Last edited by Bonaparte; 05-20-2015 at 07:35 AM.

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    Quote Originally Posted by Bonaparte View Post
    You shouldn't be trying to come up with strategies based on literature that are beyond your comprehension level, since your understanding is completely backwards.

    Being insulinogenic, arginine will boost insulin without any glucose release, thus lowering your BGL. This is a good thing.

    Epinephrine does the opposite, as it stimulates adrenergic receptors in the liver, releasing more glucose into the bloodstream (part of the fight or flight response) and slows insulin release to maintain a higher BGL.

    Of course, we all know that stimulants cause weight loss, but that has nothing to do with epinephrine's effects on insulin and BGL.
    That's why I stick to peanut butter and jelly sandwiches, or is it jelly and peanut butter?

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    Quote Originally Posted by lovbyts
    That's why I stick to peanut butter and jelly sandwiches, or is it jelly and peanut butter?
    Mmmm sammiches...
    lovbyts likes this.

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    Frontpump is offline Associate Member
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    Bonaparte:

    I don't think I have it backwards, but maybe I wasn't clear. Or maybe I do have it backwards and you can further clarify.

    Arginine>>insulin >>transport of existing glucose>>decreased triaglyceride metabolism>>fat or muscle gain (not what I currently want).

    More insulin, less weight loss. Regardless of existing blood or liver glucose.

    epiniphrine:
    -"increase degradation of glycogen and triaglycerides"
    -suppressed insulin levels
    -elevated glucagon>>"increased lypolysis"

    It looks to me as if the stimulant epinephrine is the factor responsible for weight loss, through elevated glucagon and resulting "increased lypolysis".

    I'm taking this stuff straight out of the text. And if I've got it all wrong, then I want to know that. If it's all wrong then kindly point me to your references. Hit me some with NLM.gov

  7. #7
    Bonaparte's Avatar
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    As I stated, stimulants do cause fat loss. But you original premise was far too narrow and oversimplified.
    I'm looking at the broader implications of your plan (which should include anabolism), not just catabolism at any cost.

    There are plenty of stupid things you could try by reading a particular chapter of a physiology textbook, but they'll never get you the body you want and will land you in the hospital. I remember one guy a few years ago who wanted to take some experimental drug to shut down his pancreatic beta cells so that he couldn't produce insulin , then lose tons of weight by staying in diabetic ketoacidosis. Sounds great on paper (if you have no medical background), but the end result is death within days.

    If you want to take a bunch of caffeine and ephedrine to stimulate adrenaline production, go for it. But trying to use exogenous epi is fully retarded. Of course, you'd figure that out after your first 300 mcg shot...
    Last edited by Bonaparte; 05-20-2015 at 06:36 PM.

  8. #8
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    Quote Originally Posted by Bonaparte View Post
    As I stated, stimulants do cause fat loss, but not because of their effects on insulin that you're misunderstanding.

    If you want to take a bunch of caffeine and ephedrine to stimulate adrenaline production, go for it. But trying to use exogenous epi is fully retarded.
    And you know what they say, Never go full retard...

  9. #9
    Frontpump is offline Associate Member
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    So what I'm gathering is that I'm not misunderstanding the mechanism of action...

    it's just a fully retarded idea. Roger that ghost rider.

  10. #10
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    Quote Originally Posted by lovbyts
    That's why I stick to peanut butter and jelly sandwiches, or is it jelly and peanut butter?
    myyyyyyyyyy favorite ....... Mmmmmmmm sammies

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