Will using t3(Cytomel ) while taking an Proton-pump inhibitor which helps with gastroesophageal reflux disease (GERD) and acid buildup. Examples of names omeprazole (Prilosec otc) or Protonix. Decrease the effectiveness of t3? I’m on omeprazole for acid build while eating and am taking t3 I haven’t really felt or notice t3 being that effective for me started at 25mcg then 50mcg and now 75mcg. I’m asking because when looking these 2 drugs up it says that omeprazole or protonix may decrease the effectiveness of t3 (Cytomel) and May half to increase dosage if taking these drugs.