High Estradiol Again

[bedada]

About a year ago my E2 was 88. Went on arimadex .25 2x week and it was 75. Took the Ultrasensitive test and it was 11 with the high scale being 29. I went off arimadex and increased test from .25cc a week to .50cc a week. Test level is perfect. total is 1118 with the high range at 1100. Free is 207 with range being 46-224. I feel great. Problem is E2 is 57 with the high being 29. Free Estradiol is 1.07 with the high being .45.

I don't want to lower my test. Can't believe a half CC a week is making E2 high. Is 57 something to worry about? I am going to try and find and endocrinologist but would like to have knowledge since I've been dealing with doctors for the last two years that have limited knowledge.

Thank you

[IncreaseMyT]

Sounds like 0.25mg might be the sweet spot. Sounds like you danced around that a few times but never tried it.

I would try just 0.25mg the day of or after your shot. I don't think it matters that much which day.

You should do this under the supervision of a licensed physician of course

PS Rapid Dissolve Tabs are available to our physicians, I really like this application. Melts under your tongue.

[kelkel]

E2 Sensitive Assay or standard estradiol?

[Youthful55guy]

About a year ago my E2 was 88. Went on arimadex .25 2x week and it was 75. Took the Ultrasensitive test and it was 11 with the high scale being 29. I went off arimadex and increased test from .25cc a week to .50cc a week. Test level is perfect. total is 1118 with the high range at 1100. Free is 207 with range being 46-224. I feel great. Problem is E2 is 57 with the high being 29. Free Estradiol is 1.07 with the high being .45.

I don't want to lower my test. Can't believe a half CC a week is making E2 high. Is 57 something to worry about? I am going to try and find and endocrinologist but would like to have knowledge since I've been dealing with doctors for the last two years that have limited knowledge.

Thank you

Same question as Kel. The post is a bit confusing. It sounds like you had 3 E2 tests and at least the second one at 11 (assume pg/mL) was a sensitive assay, but what about the other two? Many docs do not know how to order the right lab. My doc didn't, but at least she was teachable and I helped her find the right one through her clinic lab. When I get them myself through discountedlabs.com, it's the LabCorp Sensitive (LC/MS/MS) lab.

My humble opinion, getting misinformation from the wrong lab is worse than not knowing at all because it can lead you down an incorrect treatment path.

[Youthful55guy]

Oh, an after thought. Have you tested your SHBG? High SHBG can lead to high E2 and Total T measurements because the protein binds steroid sex hormones and prevents them from being metabolized in the liver. So high E2 could be a sign of high SHBG. The operative word there is "could" as there are many other factors involved with E2 levels.

[hammerheart]

Oh, an after thought. Have you tested your SHBG? High SHBG can lead to high E2 and Total T measurements because the protein binds steroid sex hormones and prevents them from being metabolized in the liver. So high E2 could be a sign of high SHBG. The operative word there is "could" as there are many other factors involved with E2 levels.

That might be the case with physiological eugonadism, but with enanthate /cypionate the displacing effect of test and DHT on SHBG could be massive enough to prevent significant binding of estrogens, due to stronger affinity of androgens. In fact, the opposite (imho) is more likely to happen: high SHBG combined with low E2.

[bedada]

To clarify, the first two times I was tested for E2 it was the standard. Levels were 88 and 75. The last two times I took the one KelKel told me to take which is the sensitive assay. Levels were 11 and 57.

Thanks

[Youthful55guy]

To clarify, the first two times I was tested for E2 it was the standard. Levels were 88 and 75. The last two times I took the one KelKel told me to take which is the sensitive assay. Levels were 11 and 57.

Thanks

That helps.

Just throw out the first two tests as the assay is meaningless and only gives you misinformation.

Regarding the last two tests, while taking 0.25 mg 2X per week. anastrozole and that dropped you E2 down to 11 (upper end of range 29) while on a prior 0.25 cc T (assuming T-Cyp @ 200 mg/mL), which equates to 50 mg T per week (a relatively small dose).

Then you doubled the dose and eliminated the anastrozole and the E2 jumped out of range to 57 but TT and Free T were good.

Assuming that is correct, you'll want to go back onto the anastrozole and use the labs to bring it down below about 30. I'd start at your prior dose of 0.25 mg 2X per week and then go from there with labs directing you. You do not want to leave you E2 out of range for an extended period of time.

Also, I'm assuming you are taking weekly injections, which is how many start out. I'm a big believer in breaking that dose up to into twice weekly or every 3 day injections. You'll have a smoother ride, lower peaks in T and thus a lower conversion to E2.