IGF-1 at just 11mcg per day

[ginkobulloba]

Found this article that was published in MD and written by Palumbo. I know all about this guy's rep, etc...but this article seems to make sense in regards to higher dosages creating downregulation of the receptors.



(1)-STORAGE OF IGF-1(prior to mixing)
lyophilized (dry) IGF-1is stable at room temperture for three weeks; however, it should be stored below -18 degrees celsius (in the freezer section).

(2)WEIGHT OF IGF-1
1 milligram (mg) IGF-1 = 1,000 mcg (micrograms) IGF-1 (dry weight- before mixing).

(3) WHAT TO MIX THE IGF-1 WITH
when reconstituting, its important to remember IGF-1 can get "stuck" in the grooves of the glass bottle it comes packaged in. While glass appears smooth to the naked eye, under a microscope, it's a convoluted landscape of grooves and hidden recesses.
By mixing the lyophilized IGF-1 with an "sterile acetic acid" , the IGF-1 molecules are efficiently detached from the glass and solubilized in the mixture.

(4) ADDING THE ACETIC ACID
For the purposes of mathematical ease, I suggest mixing the dry 1 milligram (1,000 microgram) IGF-1 with 3ml (or 3cc) of the "acetic acid" mixture.

(5) PRESERVATION OF THE IGF-1
Next, using a 1cc insulin syringe draw out 1cc out of the bottle containing the 3cc acid water/IGF-1 mixture. In a seperate 1cc insulin syringe, draw up another 1cc of the solution. Freeze these two loaded insulin syringes. They will be utilized at a later date.

NOTE:Freezing can safely and effectively preserve IGF-1 (even after its been mixed).

(6)THE CORRECT DILUTION
To the remaining 1cc of IGF-1 thats left in the glass bottle, add 2cc of bacterialstatic water.This will return the total volume back up to 3cc.

(7)THE MATHEMATICS
(A)The original concentration of the IGF-1 solution was 1mg(1000 micrograms)
IGF-1 in 3cc of water.

(B)Each 1cc that was removed,then,contained approximately 333 micrograms IGF-1 per 1cc.

1,000 micrograms/3cc = 333 micrograms per 1cc

©The 1cc that was left in the bottle, then, also contains 333 micrograms of IGF-1.

(D)Next,we added 2cc of bacterialstatic water to the bottle and brought the volume back up to 3cc. The difference is we now have 333 micrograms in 3cc of water (instead of in 1cc)

(E)To determine how much IGF-1 is in 1cc syringe, you must divide by three.

333 micrograms/3cc=111 micrograms per 1cc

(F)To determine how much IGF-1 is in .10cc (or 1/10thcc) we do the following.

111 micrograms/10=11micrograms per .10cc

(8)EFFICTIVE DOSAGES OF IGF-1
Dosages in the range of 10 to 20 micrograms per day(taken 10 to 15 minuters after training) are quite effective for building and repairing muscle tissue.
More importantly,these moderate dosages (by some peoples estimation)
stimulate muscle growth yet escape rapid "downregulation" of the all important IGF-1 receptors.
Without receptors to recognize the IGF-1,it doesnt matter how much you inject.
NOTHING will happen.
As dosages climb to over 50 micrograms per day,receptor downgrade increases exponentially and, from what I've observed among bodybuilders, muscle gains come to a screeching hault.

Bodybuilders will have the most sucess with IGF-1 if they follow the protocol I outlined below. REMEMBER, more isn't always better.

11 micrograms per day for 30 days (cycle 1) 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 2)** 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 3)** 333 micrograms

8 weeks OFF

** The second and third cycles of IGF-1 treatment require that the two Frozen 1cc insulin syringes be defrosted, (only defrost one per cycle).
Next, inject the defrosted solution into an empty bottle.
Further dilute with 2cc bacterialstatic water. When adding the 2cc of water, use the syringe that originally held the frozen IGF-1.
This also helps to wash the syringe and ensure that no IGF-1 is stuck inside of it.

[fossilfuel7]

Thanks for posting this article Gingko!

It's a good read regardless of P's reputation.

[TheNextBigThing]

I personally don't put much stock in that article. Not because of the author, but because my personal experiences contradict it. I remember when that article first came out, I was thinking of expirimenting with it and I was talked out of it and simply upped my dose of IGF instead. If you want to give it a shot, by all means go for it, but I will tell you that the higher I go the better the results are (actually I think there is a cutoff thats different for everyone, but thats another discussion). If you decide to do it, let us know how it turns out, it could save everyone a lot of money.

[brjrj0000]

so i was gonna do igf for the first time i read on this site i should do 60mcg is that too much?

[ginkobulloba]

Well, this article I posted says that yes, 60mcg is overloading the receptors. Everyone else says a dose like 60mcg is fine. So, it's your call. This is the only article I've seen that has dosages this low and there doesn't appear to be a whole lot of feedback from anyone that has done it, at least not on this site. Personally, if I were going to run IGF-1 and I might, then I'd strongly consider this protocol for a few reasons. Sometimes, just a little is enough, and too much can be detrimental. GH gut, which comes from the IGF receptors in your intestines isn't much of a concern at these dosages, and you'll be saving money. Then, with the possibility of seeing better gains than running it at higher dosages...what have you got to lose?

[JC2007]

I would run Gavin's protocol, personally. 60mcg 3x/week.