Melanotan 2: Protect the skin, get a tan and enhance the sex!

[RUI-Products]

MT2 (MelanotanII or MTII) is a synthetic analog of the naturally occurring class of hormones called “melanocortins”. Melanocortins are a class of peptide hormones, some of which are responsible for skin protection and the tanning process, one example of these is alpha-melanocyte stimulating hormone (a-MSH). To understand the melanocortin analog MT2 you must also have a bit of understanding about melanocortins in general.

Melanocortin hormones play many roles in the body aside from just skin protection or “the tanning process”. Melanocytes are melanin-producing cells located in the bottom layer of the skin's epidermis responsible for pigmentation formation. Although mechanisms of function for some of these melanocortins and melanocytes are poorly understood, current research is finding that they play many roles in the body aside from just in the skin. The melanocortin system in the brain is one example of many overlapping systems which regulate energy balance and it has been found that genetic mutations of this system may be a contributor to obesity. Melanocortins have also been found to play a role in the sexual functions in animals, both male and female. Researchers have even found that the administration of various types of melanocortins to result in spontaneous penile erections during studies (MT2 having shown great results here as well) and from this research there is now development of analogs other than MT2 to further research erectile dysfunction.

The focus of this article is on MT2 and its effects in enhancing pigmentation (tanning) and skin protection. MT2 was not a lone soldier out of the ashes, in fact MT2 was made after research on MT1 had begun. Researchers found a way to enhance and better utilize the effects of MT1 which led to the discovery and production of MT2. Melanotan was first synthesized at the University of Arizona and the project was headed by Victor J. Hruby and Mac E. Hadley. They found that MT1 & 2 was “approximately 1,000 times more potent than naturally found a-MSH” in test subjects. Further research showed very positive findings with MT2, with increased proliferation and melanogenesis being the main findings. The main focus of research was on the fact that MT2 research showed less DNA damage in test subjects that were subjected to UVA/UVB during MT2 treatment vs. the control group. As I am sure you know ultraviolet (UV) radiation is a major cause of skin ageing, carcinogenesis and cancer. MT2 was found to very effectively produce its protective effects by triggering a signaling cascade in the body by binding with the melanocortin receptor (MCR) on the surface of melanocytes in the epidermal layer of the skin. It does this by beginning a series of actions in the skin that result in melanocytes favoring the production of eumelanin (the protective brown pigment) over pheomelanin (red/yellow pigment). Even though MT2 has been around for a few years now and it still seems to be the most beneficial peptide for enhancing the pigmentation process and enhancing the skins protection to UV rays.

The positives do not stop there with Melanotan II, MT2 has also been found to block the feeling of food deprivation (hunger) in test subjects leading to less food hording. I feel this is just the very first steps of MT2 research in obesity. MT2 has also been found to enhance erections and sexual functions in both male and female subjects. The fact these finding show positives effects for both male and female subjects is of big interest to researches. MT2 acts more on the brain as opposed to just the sexual organs like most other compounds utilized in erectile dysfunction research seem to effect. These mentioned compounds are not found to be very effective to female subjects since the focus of sexual functions drugs is usually geared towards penile erection. This makes Melanotan II’s research findings VERY important to the scientific community. These findings were discovered accidentally while studying MT2’s effects on skin pigmentation and may yet be another possible area for research and development with MT2 and in fact a new compound has already been made from MT2 called PT-141 and it is being researched for its positive effects on female sexual dysfunction.

There are many positives found in MT2 research and the safety of this research has shown to be very high with little to no negative effects found in test subjects. MT2’s high rate of pigmentation with little to no UV stimulation has been found to be so effective that it is currently undergoing phase II and III clinical trials in subjects with photosensitivity disorders and those prone to nonmelanoma skin cancer.

MT2 research has come a long way recently. From simply looking into its effects on enhancing the pigmentation process (tanning) and skin protection, to the discovery of many other possible areas of worthy research for MT2 such as sexual enhancement, and even obesity issues; MT2 really is an amazing compound to work with. I hope this article has shed some light onto MT2’s history, possible utilizations, and how it works.

Check it out >> Melanotan II (lyophilized) 10mg

Ref:
1) Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival.Kadekaro AL, Kanto H, Kavanagh R, Abdel-Malek Z. http://www.ncbi.nlm.nih.gov/pubmed/12851336
2) The first preparative solution phase synthesis of melanotan II.Ryakhovsky VV, Khachiyan GA, Kosovova NF, Isamiddinova EF, Ivanov AS.http://www.ncbi.nlm.nih.gov/pubmed/19043625
3) Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'?Langan EA, Nie Z, Rhodes LE.http://www.ncbi.nlm.nih.gov/pubmed/20545686
4) Discovery that a melanocortin regulates sexual functions in male and female humans.Hadley ME.http://www.ncbi.nlm.nih.gov/pubmed/15996790
5) Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME.http://www.ncbi.nlm.nih.gov/pubmed/8637402
6) Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.Shukla C, Britton SL, Koch LG, Novak CM.http://www.ncbi.nlm.nih.gov/pubmed/22643233
7) Reflex penile erection in anesthetized mice: an exploratory study.Allard J, Edmunds NJ.http://www.ncbi.nlm.nih.gov/pubmed/18599219
8) MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake.Keen-Rhinehart E, Bartness TJ. http://www.ncbi.nlm.nih.gov/pubmed/17826779


Melanotan II (lyophilized) 10mg

[kelkel]

Personally I was impressed with how well it works on my Irish ars! I will definitly be using it again in early spring!

[likelifting]

I use this stuff all through the winter. It works.

[DB1982]

Curious to how safe this stuff is?

[likelifting]

^ I'm not sure about that. I do balance the use of MT2 with NOT having to spend nearly as much time in the sun.

[DB1982]

^ I'm not sure about that. I do balance the use of MT2 with NOT having to spend nearly as much time in the sun.

Yeah that's what I'm wondering? Is there any sides? Could it potentially cause cancer in the future

[gixxerboy1]

I had no sides and it worked great

[likelifting]

Yeah that's what I'm wondering? Is there any sides? Could it potentially cause cancer in the future

Nowadays, everything causes cancer if you believe the news, but I have no idea if it would cause cancer in the future. I haven't read anything about cancer and MT2.

[likelifting]

As far as sides, I get a little flushed and a little sick feeling for a half hour, but not much.

[Angel of death]

I've heard it has the potential to cause spots, no one has had that?

[likelifting]

I haven't noticed spots but I have a couple freckles and they turned DARK.

[DB1982]

I haven't noticed spots but I have a couple freckles and they turned DARK.

That's what I heard. It has been know to create moles. I was going to order some but my wife ( nurse ) told me no. She said if it can create moles or make them larger or darker then its has the makings to be cancerous .
If its true or not I don't know she nor I are Dr's.
Keep us posted.

[likelifting]

From what I understand freckles becoming darker is because my melanin levels are increased due to MT2. Increased melanin in itself will not, or should not cause cancer. MT1 was actually being used to prevent cancer in light skinned peeps by increasing melanin and darkening skin, iirc.

I have not read anything about creating moles. But I'd go with what your wife says. It makes for a better home life.

[DB1982]

[QUOTE=

I have not read anything about creating moles. But I'd go with what your wife says. It makes for a better home life. [/QUOTE]

I know right . Lol.
Im really interested in MT2. I go crazy standing still in tanners for 8-12 mins
I know I'm like a kids I got to stay moving.
And tanning beds gross me out. I know you can clean them but no thanks.

[reporich]

Ive been using it for 9 months and love it!

[Hephens]

I wouldn't use this stuff again. Made my moles bigger and darker, may have created new moles that I hadn't notice. But discontinuing it made the moles less darker. I became patchy black on my skin, looked like I came out of a chimney. But I should never have used this stuff cause I'm fairly tanned person anyway just needed to get out in the sun more.

[RUI-Products]

-USA Made Products
-Worldwide shipping
-All of our products are for research only and not human consumption

[william981125]

-USA Made Products
-Worldwide shipping
-All of our products are for research only and not human consumption

Loved how you add not for human consumption.

[Oki-Des]

I am a white guy, but can tan pretty good. I loved this stuff because it made me horny as hell and gave me awesome sex dreams. The only downside was it made me way too tan. I am married to a Latin woman and was the darkest one in the family. Lol. It also made my head darker than the rest of my body. Everyone made fun of me for a while and my dad knew straight away that I was on it. He is a doctor, but I was still surprised when he called me out on it. If you want a tan, this will do the trick; and then some. If it did not make me so tan, I would be on it for life. I tried PT 141 just for the sex sides without the tan; but it wasnt the same. Great product and I give it a thumbs up if you want a super tan!

[djgreen]

what are the sex sides do you get a boner right after you inject only or would I walk around all day with a tent

[Far from massive]

This is far from definitive but I was diagnosed with Goblet cell carcinoids (In my appendix) about 2 years ago while on it and asked my Oncologist if this could have been the cause or a contributing factor. He said "no not likely" which is very strong language for a doctor on a self administered drug.

[swiftly]

I get this same nauseous feeling so I take it in the evening right as I'm getting into bed so I don't really notice the nausea