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Thread: GHRP no anabolic effects
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01-07-2013, 07:37 PM #1
GHRP no anabolic effects
Hi dear friends,
Everything what I've heard or read says that peptides do rise GH levels very successful, but there is no rises in IGF levels and no anabolic effects proven. Lets say you get 1iu GH from using peptides - it has not the same effect as you would pin real GH 1iu.
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01-07-2013, 09:12 PM #2
If GH levels are increased why would IGF levels not be increased? Do you have a source to support your statement?
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01-07-2013, 09:39 PM #3
I would like to know about this aswel and why doesn't it work the same? Hopefully a more knowledgable member will help. This is the issue I am having with bluetops, high growth hormone levels and barely any igf increase, it's very common with alot of these generics and peptides would be the same aswel.
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01-07-2013, 11:20 PM #4Associate Member
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All I know is the stuff works. The gains are slow but sure..
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01-08-2013, 12:20 AM #5Banned
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I'm sure there are people that wouldn't like it to be said but peptides are a fu*king joke....Only exception is TRUE LEGIT IGF-1, WHICH NO ONE will ever get anyways....
You can add it to that long list of supplements you don't need that you pick up at your local nutrition shop
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01-08-2013, 02:24 AM #6
i've been asking you this for i don't know how long, but what the hell are you talking about "nobody will ever get true legit igf-1?" and then you go on to call igf-1 lr3 garbage. is that right? why do pro bodybuilders take it? my dad took igf-1 lr3 during his last cycle, and saw spot improvement like he had never seen before, and this is a guy who has been cycling for over 20 years with pharm grade aas, and pharm grade hgh. all of a sudden he is going to imagine shit up because of a placebo effect? get real!
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01-08-2013, 02:54 AM #7Originally Posted by kaptainkeezy04
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01-08-2013, 02:55 AM #8Originally Posted by kaptainkeezy04
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01-08-2013, 03:30 AM #9
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01-08-2013, 03:41 AM #10
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01-08-2013, 08:54 AM #11Banned
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Because I'm not talking about lr3 garbage and neither am I really talking about for spot improvement....I'm talking about bio identical igf-1, you know, the sh*t your liver produces after you inject hgh...
This is the only igf-1 that matters...This is outcome of hgh....This is where your growth come from...Even for all the pharm grade gh users your body only wants to pump out so much igf-1 after a while...Bodybuilders need bio igf-1 to keep gains coming and coming....
The real sh*t is WAY expensive and fragile....Plus there is just too much fake sh*t people are trying to sell...This whole lr3 is shenanigans...It also needs to be taken with pharm gh for MAXIMUM results...
Just like hgh, if you don't have PHARM GRADE IGF-1 take a moment, set it down and then smash with a hammer...It's useless and pointless and a waste of money...
You talk up your pops as if he is kevin levrone, can't he answer all your questions?Last edited by calstate23; 01-08-2013 at 09:01 AM.
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01-08-2013, 08:58 AM #12Banned
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he is correct but i dont think he even knows why he is correct lol, systemic levels arent increased from ghrh/ghrp (which is what a igf bw looks for), it raises autocrine/paracrine IGF which is basically in the cells themselves and hard if not impossible to measure
Last edited by DanB; 01-08-2013 at 09:03 AM.
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01-08-2013, 08:59 AM #13Banned
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01-08-2013, 09:26 AM #14
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01-08-2013, 09:30 AM #15
I tell you something guys, I'm gonna safe my money in the future and going to invest in amino acids like bcaa and so on rather than peptides. The only peptide I'll keep buying is melatonan II - it makes me horny at least
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01-08-2013, 09:32 AM #16
GHRH (Growth Hormone Releasing Hormone) + GHRP (Growth Hormone Releasing Peptide) = 10 star GH Release (**********)
GHRP (Growth Hormone Releasing Peptide aka Ghrelin-mimetic) = 3 star GH Release (***)
GHRH (Growth Hormone Releasing Hormone) = 0 or 1 star GH Release (*)
GHRPs (GHRP-6, GHRP-2, Hexarelin, Ipamorelin) are like cardiac shock paddles. You administer a GHRP and a pulse of GH is created. This is predictable and reliable across all normal people.
GHRH creates no pulse. It only adds to what ever is happening naturally. If there is a pulse occurring then GHRH increases the GH release. If no pulse is occurring when GHRH is administered then it will have little effect on GH release.
I can not speak for Dr. Crisler but he indicated that Sermorelin (GHRH) by itself was not very effective at raising IGF-1 levels. However when he added GHRP-6 with it at saturation dose (I believe administered together twice a day), IGF-1 levels increase by 1/3.
This underscores the need for both a GHRH & a GHRP.
IF you are 100% sure you have CJC-1295 (and the odds are against it) then because it is a long lasting GHRH (half-life measured in days) it will always be available which means during natural GH waves & troughs. So it behaves differently and its effectiveness in terms of absolute GH release is higher then the other forms of GHRH.
CAVEAT - CJC-1295 raises base levels of GH not the pulses. It is possible that CJC-1295 never gives the somatotrophs sufficient time to reload stores of GH at the 100% level. Normally Somatostatin by stopping GH release activity gives the cells sufficient time to build up a big store of releasable GH. So CJC-1295 no matter how much GHRP you add may not be able to effect as strong a pulse as a GHRP + GHRH.
There is no reason NOT to combine a GHRP such as GHRP-6 with your GHRH, no matter whether the form of GHRH is Sermorelin, modified GRF(1-29) or CJC-1295. There is only BIG benefit.
On the flip side you can consistently and reliably effect GH pulsatile release with a GHRP alone. Without a GHRH the amplitude will not be synergistically higher. BUT it will be a strong pulse of GH release.
One more quick point. An iu of synthetic GH is 333mcg of compound. Thats all. A unit of GH doesn't give the same effect across all normal people and even within a person there is variability.
A far better measure is GH in plasma measured in many multiple intervals over a period of time. By sampling frequently you can determine the peak of GH in plasma and when it drops to baseline.
You can then measure IGF-1 levels to determine the effect that THAT dosing had on increasing circulating levels.
You can do the same thing with GHRH & GHRP.
The problem people have is they are stuck on absolute levels of GH in circulation as being of paramount importance. It isn't.
First it is free GH that is important. Anywhere from 10% to 90% may be bound at any given time with GH-Binding proteins or prolactin-binding proteins.
Second it is pulsation that is important for growth not absolute levels. Pulses send communicative signals to the cells. GH is simply the ligand that gives form to the wave. GH has no other value except to be a part of a communication signal.
The cells respond to this wave of GH by mediating events within the cell that are responsible for metabolism, protein synthesis, further ligand transcription & synthesis in the form of IGF-1 ...some of these signaling pathways in the cell carry messages to proliferate, differentiate or induce apoptosis . These intracellular pathways are common to many different tissue populations and respond to initiation from many different types of ligands binding to various receptors.
This behavior is optimized by pulsation ...continuous GH desensitizes these pathways (and sends certain signals that are common to females to mediate certain events such as creation of specific liver enzymes)...
So it is probable that I (and anyone who understands fully) could get more out of a small amount of GHRH + GHRP then someone who administers large amounts of GH. The validity of this statement is dependent on the use of other compounds...
Finally to answer your question directly:
I believe that if your CJC-1295 is modified GRF(1-29), coupled with GHRP-6, dosed as described you will achieve your goal of GH level (i.e. 2-3ius) and exceed both the quantity & quality of those growth optimizing events that THAT equivalent level of synthetic GH will be capable of mediating.
credits to others for this info, so yes you are correct no GHRP has little effect alone. Al old info theres no point to run alone as its a hit or miss.Last edited by largerthannormal; 01-08-2013 at 09:48 AM.
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01-08-2013, 09:43 AM #17
Cant wait for calstate23 to get ahold of that one , LOL...( i know he hates all this talk bout peps) I do personally agree it will not yield the same outcome of synth pharm grade gh if it would everyone would be on them and look like him..............
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01-09-2013, 06:35 AM #18
I have to respectfully disagree with you guys...you won't get aas results from peptides (GHRP/GHRH) but they are an effective tool in putting on slow lean amounts of muscle. I've been on GHRP/GHRH for alittle over a year now without aas usage and where as 1 year ago I was 193 lbs. @ 12% bf I'm now sitting at 203 lbs. at that same bodyfat. I normally pin 100mcg each (GHRP/GHRH) 3-4 times per day. 1 year ago my maintenance cals were 3200-3300 but now 1 year later on peps my maintenance cals are close to 4000 cals. So you see the peptides allow me to eat more cals while staying just as lean if not leaner then when not on peps. I will say that I about gave up on peptides 3 months in as results were somewhat non-existant (other than improved sleep), but I was told to continue running them as results will build overtime and boy am I glad I did!
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01-09-2013, 06:35 AM #19
Also, largerthannormal great info!
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01-09-2013, 07:39 AM #20
Thanks bro!
Imola , i hope to have your results as well thats a pretty significant difference for 1 year, yes you had more cals which people will say is your reason but for you to stay the same bf% is pretty cool!!
im 2 weeks in and i feel good!!! hope in 2-3 months I can see small visual changes!!
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01-09-2013, 07:44 AM #21
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01-09-2013, 09:51 AM #22Banned
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You can also get some results from low grade pro hormones too....I'm not saying you can't get ANY results whatsoever....But why? Why would I take testosterone boosters or a low grade pro hormone cycle when I can take Pharm grade anabolics?? I can also get SOME results from generic gh but again why would I do that? It isn't even comparable..
I'm also referring to the peptides 99% of the people are using, compared to pharm grade bio identical gh, igf-1 etc. etc.
Advanced bodybuilders are not using this type of products....All pharm grade high quality products and that's itLast edited by calstate23; 01-09-2013 at 09:55 AM.
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01-09-2013, 11:02 AM #23
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01-09-2013, 01:48 PM #24
Pro hormones will shut you down, aas will shut you down, peptide don't. You can run them post cycle and bridge your cycles with them without any worry of harming your endo system. GH costs alot more aswell and is faked much more often.
And as far as saying advanced bb's arnt using these products, that's just not correct. Some may not, some definately are.
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01-09-2013, 02:24 PM #25Banned
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There is also GARBAGE pro hormones that don't do sh*t either! So you also think someone would achieve the same results on test boosters then a cycle test, tren , and mast??
Ha ha come on, apparently you are not getting my analogy here! You are talking about stater bros select steak and I'm talking about Morton's Steak House...
You are wrong, no advanced bodybuilder that COMPETES uses the garbage you talk about! Waste of time and money. Now do I say all they use is ONLY Pharm grade direct from Manufacturers? No, but they will only use something proven worthy that actually gets RESULTS
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01-09-2013, 03:29 PM #26
Where did I say anything remotely close to "someone would achieve the same results on test boosters then a cycle test, tren , and mast?"
I get your analogy, but my orignal post stated my thoughts on it. Juice will shut you down, you cant run it safely post cycle or bridge (when I use peps). There is a time for everything, I never said peps were as good as aas or close to it, they are not, but they are better than nothing. I would rather gain slowly post cycle with my peptides than slowly lose my gains. They do help, I know from experience and studies that prove they do. If I could afford real GH i would run it. But between running chinese gh and spending more doing so and not knowing if its legit, Ill chose my peps that I know are legit and have worked for me in the past. My personal preferance.
Sorry bro, you are wrong about your last line.
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01-09-2013, 05:19 PM #27Banned
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You didn't say anything remotely close to that...But I'm making a comparison similar to what you are talking about....Comparing your "peptide" cycles to pharm gh is like comparing test boosters to the cycle I posted...Not even close...My point being save your money..
And sorry to you bro, but YOU are wrong...Many guys have to drop out of comps because they don't have enough money for the hormones they need...Do you think they are going to be wasting money on piece of sh*t peps? get real
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01-09-2013, 06:32 PM #28
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01-09-2013, 08:13 PM #29
I haven't read much about peps but I don't understand this ^^^^ even though I've heard it many times.
GH whether from a natural pulse or from injected rHGH is synthesized by the liver and causes the release of a few different growth factors, most importantly IGF-1. Even though many different types of cells have GH receptors that GH binds to (adipose tissue for fat loss for example) the main benefit (at least as far as anabolism goes) is the IGF-1 spike. So if there's no systematic rise in IGF-1 levels then it seems there's not much point in running peps other than healing and fat loss? And how could the GH released from GHRPs not have the same effect as all other GH?
And I'm not gonna use the search function I'm lazy and want an answer.
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01-09-2013, 11:18 PM #30Banned
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Ha ha I don't...Just realistic though....
Also, my point being is that who is to say you are even getting TRUE peptides? Just like if you don't get pharm grade gh there is really NO WAY of knowing 100% what you are even getting....
Just like all the other bogus products people make who is to say that it is even what they say it is?? And still, EVEN if it was it doesn't have a MAJOR impact...I've used Sermorelin with GHRP-6 that was even prescribed by doctor and I'd way rather use gh.....
Imagine trying to use anti estrogens to raise your test levels as if it were a cycle....Just not the same then having the direct hormone injected and pumping through your body..Last edited by calstate23; 01-09-2013 at 11:24 PM.
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01-11-2013, 06:42 AM #31
You can do it bro! I'm not attributing all of my results solely to the peptides as training and diet has improved somewhat too. That being said I'm amazed at the recovery and the amount of cals (even sloppy cals sometimes) I'm able to ingest while staying lean. Yeah you're right some will say "no wonder you gain weight, you upped your cals" but I've upped my cals to around 4K while not on peps and all that lead to was soft, sloppy gains. Largerthannormal, try to increase your cals gradually. It helps to be fairly lean to start with (I cut down to a low body fat % before the peps which helped w/ lean gains).
Exactly right! I mean if I didn't care about my overall health and the possibility of having kids one day I could just blast and cruise on test. There's no doubt I would grow and respond to this well, but in the overall grand scheme of "life" it's not worth it to me! I'm not a professional bodybuilder nor do I want to be. I body build to look good and from the health standpoint too. I've done several aas cycles as well as many prohormone cycles and I know my body responds well but instead of many that say "fuk it I'll just stay on" I come off and run a proper PCT. Because of this I'm 32 in descent shape, great health, and my test levels are around 700 (LH, FSH, and estrogen all look good). The reason I like peptides is there's no negative feedback or shutdown and to date I haven't read about any adverse side effects. Sure they're not exactly cheap but I've seen great results from them and don't plan on stopping usage anytime soon. Peps get the thumbs up from me!
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01-11-2013, 05:51 PM #32
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01-14-2013, 06:53 AM #33
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01-14-2013, 02:21 PM #34
you are right, why would pro bodybuilders use peptides while they are cruising on AAS and HGH all year long
but from what i read that you can use peptides at PCT and after that till time for your next cycle and keep gains from the cycle and occasionally gain more
dont you think that this is true ?
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01-14-2013, 03:51 PM #35
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01-15-2013, 07:20 AM #36
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01-15-2013, 01:37 PM #37
i have been up a few hundred cals( i re added and im 400 higher than when i was on cycle. im up 4 lbs in 2.5 weeks and i look leaner in the areas that count and muscles appear fuller. Im sure this is due to the extra cals im taking in.
another note lifts are up ridiculous in the past 2.5 weeks? im only 190 and my sets of 15 at 245 were butter on flat last night. I could play with the weights let it sit on my chest for seconds even at set 3 rep 15. I dont know what this is to contribute to? thats about 20lbs higher than normal for me and i usually struggle on 12-15 on my last set.
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01-16-2013, 12:23 AM #38New Member
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looking at all the long term members posts im sure mine will be bashed but i have been on ghrp-2 and mod 1-29 for about 5 or 6 weeks now and i started my pct 3 weeks ago of clomid and nolva. when i started my pct i was probly at a high 14%bf at 232lbs (my cycle was sust and winny) i put on a ton of size in this cycle and strength and i notice my joints suffering and my health. an amateur bb'r recommended these peps to me for my joints and healing. as far as my results go i certainly feel MUCH MUCH healthier in my joints and over all well being then i ever had on previous pct where its usual the most brutal experience i could imagine. i am sitting at 222 right now probably about 11-10% bf and none of my lifts have decreased rep or strength wise and i have REDUCED my calls in effort to drop some bf%. you can say all you want that these peps are garbage but how about you try them instead of reading online forums for you bro-formation. peps are inexpensive and i think are going to be part of any PCT i ever do. PCT is about recovery and they certainly did their job.
to be straight i am NOT saying these will give you anywhere near the anabolic results of gh, igf-1 lr3 or aas BUT they certainly should hold their place among gear heads for maintaining gains without hurting long term hormonal balances.
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01-16-2013, 07:10 AM #39
Dude that's strong for your weight...I'm jealous. I will be gearing up for a 10 week aas cycle here in a few months....can't wait!
Preach on brother! Thank you for your first hand experience w/ peps...you're right to many people go of hearsay or bro-science!
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01-16-2013, 10:56 AM #40
In about 3 months I will be doing one as well, And thanks man, My bench has been my all time weak point but the past 3 years I blasted it 2x a week changing up 5x5 3x15 4x10, 1x50 2 x 40 ( wierd stuff like that) alternating flat & incline dumbells and barbell. I was going for my states record on a single 3 months ago but it just got bashed by 30lbs from another guy, unofficially i took it prior to the bashing and was preparing for comp( I am not a power lifter by no means, just a fun thing i attempted to give a whirl) last competition local to me was cancelled, then I seen what was taken up north and I decided to hold off. Thats sports not for me just was a spare of the moment thing to maybe do on a weekend. I was going to compete at 181 raw mens open.
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