Why it’s worth combining IGF-1 and GH

[Turkish Juicer]

Why it’s worth combining IGF-1 and GH

It would of course be horrendously expensive, but in theory there’s a lot to be said for combining growth hormone [structure shown below] and IGF-1, writes the Dutch endocrinologist Joop Janssen in an article in Reviews in Endocrine Metabolic Disorders. The article is worth looking at if you’re a chemical athlete.

The first argument that Janssen comes up with is that IGF-1 remains active for longer in the body if you inject it in combination with growth hormone . This is because IGF-1 is active for longer if it is attached to the binding protein IGFBP3. If you inject IGF-1 on its own, the production of this binding protein goes down. But if you inject growth hormone and IGF-1 together, the concentration of this binding protein increases. That might mean that you would have to inject less frequently, as IGF-1 breaks down quickly in the body.

A second argument is that growth hormone makes the cells ‘ignore’ insulin . As a result, blood sugar levels rise, as does the insulin level. In the long run this might not be so beneficial to health, and it would inhibit muscle growth. If you use IGF-1 together with growth hormone, then the muscle cells become more sensitive to insulin. And that would mean more muscle protein build-up.



The advantage of combining IGF-1 and GH is also a potential disadvantage, according to Janssen. The same processes involved in muscle growth are also found in cancer cells and tumours. The combination of both hormones might therefore give any tumours a growth stimulus. The same applies to other side effects such as undesirable growth of the jawbone, headache and trapped nerves in the hands.

In the final section of the article, the endocrinologist stresses that there have been very few studies on the effect of combined administration of GH and IGF-1, and that his article is mainly theoretical. "Determination of whether coadministration of GH and IGF-I is indeed superior to GH alone or IGF-I alone awaits further study", concludes Janssen.

Source:Rev Endocr Metab Disord. 2008 Jul 6. [Epub ahead of print].

ergo-log

[ScotchGuard02]

Good article, I did read an article about IGF-1 and tumor growth. The study basically said that that the the tumor generated IGF-1 "like" substance to fuel tumor growth. However, it was inconclusive if the IGF-1 produced by the body, that is external to the tumor, actually is used by the tumor to fuel growth.

[Granovich]

guys are we talking about the IGF-Lr3 research peptide ?
because i believe the IGF-1 in this article isnt the same as the research peptide.
Great read TJ. thanx

[Granovich]

Good article, I did read an article about IGF-1 and tumor growth. The study basically said that that the the tumor generated IGF-1 "like" substance to fuel tumor growth. However, it was inconclusive if the IGF-1 produced by the body, that is external to the tumor, actually is used by the tumor to fuel growth.

hey scotch can you please elaborate on that . was the Igf-1 what cause the creation of the tumor or helped it to grow faster
also do you mean taking IGf-1 or that could happen from taking HGh which will increase IGF in the body
its scary

[Granovich]

sorry about multiple comments. Tj what does Protein breakdown means and why GH increase it ?
isnt that like braking down Fat which means " BURN " it
so is GH protein wasting ?? cuz my understanding GH is great in retaining muscle and alot of people use it successfully between cycles to retain muscle. thats what im planning to do anyway

[Turkish Juicer]

hey scotch can you please elaborate on that . was the Igf-1 what cause the creation of the tumor or helped it to grow faster
also do you mean taking IGf-1 or that could happen from taking HGh which will increase IGF in the body
its scary

Let me answer this question on his behalf, since I have already read your question:

IGF-1 doesn't cause tumor formation; however, it accelerates the process of tumor growth, if a tumor were to exist.

I had a 2 inch benign tumor removed from my belly about 3 months ago, pathology results confirmed it was the ''neo-plastic'' tumor type, none of the top-notch doctors I had talked to seemed to have an idea about ''what may have caused the formation in the first place'' because there are way too many variables to make a successful guess. For the record, I had never used HGH, IGF-1 LR3 and/or Insulin before the actual formation of this tumor started to take place, so go figure...

[Perseverance1]

What about ghrp-6/cjc-1295 without dac +++ igf-1 lr3?
Same thing?

[M302_Imola]

So I'm assuming the article is referring to anything that elevates IGF-1 levels (insulin or IGF peptide)?

[Bonaparte]

Couple issues here:
1) Actual IGF-1 is hard to obtain and expensive.
2) Janssen seems to ignore the fact that GH converts to IGF-1 and that the two hormones do already act synergistically this way (the converted IGF-1 prolongs remaining GH's half-life).
3) GH pinned sub-Q lasts plenty long for performance enhancement purposes, so dragging out the active life would only appeal to those needing actual GH replacement.
4) IGF-1 is taken up largely by local receptors, so his theory must involve pinning both IV.

[M302_Imola]

Couple issues here:
1) Actual IGF-1 is hard to obtain and expensive.
2) Janssen seems to ignore the fact that GH converts to IGF-1 and that the two hormones do already act synergistically this way (the converted IGF-1 prolongs remaining GH's half-life).
3) GH pinned sub-Q lasts plenty long for performance enhancement purposes, so dragging out the active life would only appeal to those needing actual GH replacement.
4) IGF-1 is taken up largely by local receptors, so his theory must involve pinning both IV.

GH clearing time really depends on how much HGH is used. I wouldn't expect 2-3 iu's HGH to keep GH levels elevated for more than 6 hrs. and that's being conservative...now 5-10iu's is a whole other story. You've brought up some good points here.