3N-GH lasts 24 times as long as regular growth hormone

[Turkish Juicer]

Researchers at Novo Nordisk are working on a new generation of growth hormone analogues, which users have to inject far less frequently than the growth hormone currently available on the market. According to a study published in Endocrinology, the pharmaceutical company has a hormone that lasts 24 times as long in the body as regular growth hormone does.

The biochemical trick that Novo Nordisk, maker of NovoPen [shown here] with which chemical athletes will be familiar, is using has already been used by the pharmaceutical company Amgen. Amgen produced Aranesp by attaching the EPO molecule to sugar groups. The result was an EPO variation that lasts longer in the body. The sugar groups get in the way of enzymes that break down the EPO hormone.

So we can do that too with growth hormone , thought the researchers at Novo Nordisk. Human growth hormone is a long chain of 191 amino acids. The researchers made genetically modified cells attach a sugar chain on the amino acids 93, 98, 99 and 104. Because the modified cells attached an amino acid to 98 or 99, but not to both, the new analogue had 3 new sugar chains.



The researchers call their new compound 3N-GH. The N stands for N-glycosylation: the chemical term for attaching a glucose-based sugar chain to an N atom on a side chain of arginine or asparagine.

The researchers injected their new preparation into rats that were no longer able to synthesise their own growth hormone. Because the half-life of 3N-GH was extended by a factor 24 compared with regular growth hormone, the animals grew much faster from a one-time injection of 15 nanomols 3N-GH than from daily injections of 10 nanomols.





This is because 3N-GH led to a long-term rise in IGF-1. GH stimulates growth mainly by raising the IGF-1 level.

It’ll be a while before 3N-GH makes it onto the market though. Reading between the lines of the article, the researchers have not yet perfected the production process.

Source: Endocrinology. 2010 Nov; 151(11): 5326-36.

ergo-log

[marcus300]

Long acting growth hormone that's injected once a week

[human project]

When will it be available?? And are there any projections of cost?

[M302_Imola]

Seems as though this would raise systemic IGF-1 levels which wouldn't be good from a health stand point. I prefer to use my GH in a pulsation manner in which you have a spike lasting around 3 hours followed by a trough...seems as though you would have no trough with this long acting HGH which might sound appealing to some but the trough is important at refreshing pathways so when a large GH spike is induced again it can work it's magic.

[human project]

Seems as though this would raise systemic IGF-1 levels which wouldn't be good from a health stand point. I prefer to use my GH in a pulsation manner in which you have a spike lasting around 3 hours followed by a trough...seems as though you would have no trough with this long acting HGH which might sound appealing to some but the trough is important at refreshing pathways so when a large GH spike is induced again it can work it's magic.

You know i was just talkin about this window in reference to when to take your t4 in connection with hgh..... Since there is only a 3hr window I've been thinking about taking my t4 before bed and takin my hgh as soon as I wake up so t4 is already present..... Just a thought.....

[beerdogg]

I believe the T4 half life is 24 hours. I thought I read that somewhere. I take my T4 when I wake up then pin.

[M302_Imola]

You know i was just talkin about this window in reference to when to take your t4 in connection with hgh..... Since there is only a 3hr window I've been thinking about taking my t4 before bed and takin my hgh as soon as I wake up so t4 is already present..... Just a thought.....

Not a bad idea but I've never had a prob taking my T4 at the same time as my HGH as beerdogg stated T4 has a long half-life.