Cjc 1295 with Dac bad idea for recovery and joint and connective tissue repair?

[greenwell001]

I understand that the cjc 1295 with Dac will cause gh to "bleed" out of the pituitary at a steady rate. I have read that you can still get normal pulses over the base "bleed". I am a fighter and really just want to recover and get the sleeping and connective tissue benefits, but a little extra lbm would be a positive as well, but that's not the goal. I want pinning to a min hence just running one peptide. The disadvantage to the bleeding is what I don't fully understand. Thoughts, suggestions.

[greenwell001]

Ok, I have read ar-r post about the constant flow of gh released via the pituitary, notably they say nothing negative about this. But states using ghrp for the pulses of gh. I know most everyone on here is using peptides for lbm growth and that's great, but I am a lean 205 lb fighter and don't really need massive gains from it. I'm guessing I will still get pulses through natural ghrelin release. I don't want to use a ghrp because of the strictly timed pinning for gh pulses. Again my goal is recovery, better sleep, and tendon and joint/tendon repair. Times roman, swifto, thoughts?

[956Vette]

Hey greenwell001, there are other reasons besides GH bleed to would avoid the CJC-1295 (DAC), namely the complex manufacturing & cost assoc (to attain legit CJC). Might be better off to inject intermittent vials of either rHGH or TB-500 (for rest/recovery/healing/lbm). GHRH alone is for grandpa & offers little value for a fighter imo....

[greenwell001]

Hey greenwell001, there are other reasons besides GH bleed to would avoid the CJC-1295 (DAC), namely the complex manufacturing & cost assoc (to attain legit CJC). Might be better off to inject intermittent vials of either rHGH or TB-500 (for rest/recovery/healing/lbm). GHRH alone is for grandpa & offers little value for a fighter imo....

thanks vette, it's been a while since I've been on here I almost forgot about you. I will look at times roman tb- 500 log. I will have to research the half life of the rhgh.

[greenwell001]

This came straight from ar-r

CJC-1295 is a Growth Hormone Releasing Hormone Analogue. Growth Hormone Releasing Hormone (GHRH) is a peptide hormone that is produced in the Hypothalamus. It stimulates receptors on the pituitary gland to release Growth Hormone. This occurs in what is known as a “pulse pattern”, meaning the release is not consistent and steady but occurs in spurts if you will.

CJC-1295 is an analogue of GHRH, meaning it physically and chemically mimics GHRH, inducing the same effect as GHRH itself within research subjects. There is, however, one major difference between CJC-1295 and GHRH. CJC-1295 has something called a Drug Affinity Complex (DAC) added to the peptide chain. This essentially protects the CJC-1295 from being broken down, extending the half-life of CJC-1295 making it much longer than GHRH itself.

So what ultimate effect does this have on the research subject? Well instead of a pulse or spurt of Growth Hormone (GH), there is a steadier, sustained and constant release of Growth Hormone, raising levels and keeping them increased for quite some time. This allows the Benefits of GH to be observed over a much longer period in research subjects.

What are those benefits? Well an increase in GH has been proven in research to improve lipolysis (fat burning), an increase in lean body mass (muscle), an improved sense of emotional well-being, higher energy levels, improved sleep, and increased IGF (insulin -like growth factor). The increased expression of insulin-like growth factor should not be overlooked in our research. IGF is a primary hormone responsible for muscle development and maximal muscle growth in research subjects.

So essentially rather than the above benefits being experienced in peaks and valleys throughout the day, CJC-1295 affords researchers the opportunity to induce these benefits in a sustained manner, throughout the entire day! One can surely see the benefit to this effect in our research. Another additional benefit to the increased half-life of CJC-1295 over GHRH is that the administration frequency to our research subjects is greatly reduced.

It becomes relatively easy to see the benefits afforded by CJC-1295 in our research; however it is important to talk about possible ways to synergistically optimize or maximize those benefits. One of the primary ways one can do this in their research is to combine CJC-1295 with a Growth Hormone Releasing Peptide such as GHRP-2 or GHRP-6. Why is this? Well there are a couple reasons.

GHRP-2 and GHRp-6 act in a different manner to essentially induce the same effect. Rather than exert there effect from the pituitary and on the hypothalamus like CJC-1295, they exert their effect on the Ghrelin receptor. This is another extremely effective way to induce the release of Growth Hormone in research subjects. Essentially utilizing these 2 different pathways allows the researcher to induce maximum GH release in their research subject.

Also by utilizing the combination of CJC-1295 and a GHRP (2 or 6), a researcher is inducing the release of GH in 2 different manners. One is a sustained, steady release (CJC-1295), the other is in a pulse type release or spurt (GHRP 2 or 6). This affords quite the powerful 1-2 GH punch in research subjects. You have sustained, steady, increased GH and IGF throughout the day, exerting their benefits in research subjects from the CJC-1295. Then you also have peaks in GH at optimally timed intervals that correspond with the naturally occurring GH release patterns form the GHRP. The combining of these 2 GH release patterns may very well offer the best of both worlds when it comes to the benefits of increased GH and IGF in research subjects.

As you can observe, CJC-1295, whether used alone or in conjunction with a GHRP, offers significant benefits that can be observed in our research subjects. CJC-1295 is an often misunderstood peptide that’s benefits and effects can be quite profound in our research. By understanding exactly how CJC-1295 and what it does, a researcher can optimize its benefit, making it a valuable addition to our peptide research stable.

We sincerely hope this write up has helped you to understand CJC-1295 a little bit better. How it works, what it does in research subjects, and how these effects can be optimized in our research. Get your CJC-1295 at our store now!

Check it out > CJC-1295 2mg

Refs:
*Stand, Kim (24 September 2013). "Current Research Findings Regarding CJC-1295". EP. Retrieved 27
*Kalia, J.; Raines, R. T. (2010). "Advances in Bioconjugation". Current organic chemistry 14 (2): 138–147. PMC 2901115. PMID 20622973
*Tang SS, Zhang JH, Du MH, Wu J, Liu JJ (2004). "Construction and activity of a novel GHRH analog, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys.". Acta Pharmacol. Sin. 25 (11): 1464–70. PMID 15525469
*Woods AG, Guthrie KM, Kurlawalla MA, Gall CM (1998). "Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats". Neuroscience 83 (3): 663–8. doi:10.1016/S0306-4522(97)00539-3. PMID 9483550
*Obál F, Krueger J (2001). "The somatotropic axis and sleep.". Rev Neurol (Paris) 157 (11 Pt 2): S12–5. PMID 11924022
*J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. Epub 2005 Dec 13. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Teichman SL1, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA.
*Cell Immunol. 1991 Sep;136(2):291-302.Growth hormone releasing hormone receptors on thymocytes and splenocytes from rats. Guarcello V1, Weigent DA, Blalock JE.

[greenwell001]

I believe I will try this peptide out and if and when I have time I will keep a log if anyone is interested. Vette, the way arr describes it, the Dac makes it better than a ghrh. It sounds like it could be what I'm looking for. Hey, it's only $360 for 6 weeks supply @ 2mg/wk. hopping I will see results by then. Thanks for the input vette. Wishing I had the time to pin ghrp with it but no way can I pin 3x per day and train/work/eat and keep my little girl entertained. Geez

[Juced_porkchop]

I would rec ghrp2 and sermorelin from arr. also I would rec you look into TB500. great stuff

[greenwell001]

I would rec ghrp2 and sermorelin from arr. also I would rec you look into TB500. great stuff

I don't want to pin 3x ed, that's why I didn't choose the ghrp2 or 6. Have you had experience with sermorelin jp? I have read it is like 1295 w/o Dac but not really as good which I would still have to pin 3x ed. I read tr's tb 500 thread and it seemed to me it didn't repair/strengthen anything, just reduced inflammation. Anybody with experience with 1295 with Dac or any other comparable peptide with long half life? I have seen the research and so far have not found any negatives for it. Seems the best part about it is base level gh comes back up very quickly after insulin is introduced whilst ghrp and mod (30 min half life) disappear quickly. Please correct me if I am wrong, I'm only about 6 hrs in on research and prefer individual experience if you guys have any.

[greenwell001]

bump^^^^^