HGH injections and you liver

[kaptainkeezy04]

One thing I've read a few times is different people posting on various boards that things like tren "make my igf-1 levels go down" or "hgh doesn't do anything for me" etc. I'm of the opinion that what you get out of hgh is heavily dependent on having a healthy functioning liver, because this is where hgh is converted to igf-1. Taking large numbers of compounds, especially those that are harsh on your liver (like tren), will reduce your liver's ability to function properly and effect whether or not it proficiently converts hgh to igf-1. I would love to know if anyone has ever had their igf-1 levels tested on the gear and off the gear to see the difference.

You can obviously get bloodwork done which will tell you what you need to know about your liver, among other things, but there are often some telltale signs. Back acne (for me) is typically one of the signs that I am not taking care of my liver enough when on a cycle. For ages I would try all the different cleansers, chug water all day, etc. trying to clear up my back acne. One day I read about the liver and it basically being the filtration system for your body, and how acne in adulthood can be directly related to healthy liver function. The acne conversation is a side topic, but I just wanted everyone to know that there are some visible signs to be aware of.

I think to get the most out of your hgh injections and natural pulses, it is important to take milk thistle, liver detox pills, etc. year round (my back acne always clears up when I get on a good regiment of liver cleansers). If not for the sake of your expensive drugs, at least do it because of the fact that you only have 1 liver

Thanks for reading, I hope this helps.

[GearHeaded]

a healthy liver is vital for not only over all health, but for gaining muscle or getting lean.


regarding the topic at hand though, a lot of supposedly "liver toxic" AAS actually INCREASE Igf , not lower it. When taking Methylated oral AAS , like Dbol for example, your IGF levels go up, not down. this is likely a response to the way the liver is having to break these compounds down and metabolize them (this is much more pronounced with estrogenic based compounds like Dbol compared to non estrogenic compounds like Var)..

also with Tren , its notorious for increasing IGF levels (even higher then what some HGH dosages would provide) . but I do not think this has anything to do with liver toxicity though , I think it has way more to do with estrogen and its via estrogenic effects that IGF is being elevated from Tren, and not the Tren itself. whats happening is that Tren is a Progestin and it will act on progestin receptors in the body, which will then overly sensitize estrogen receptors.
its estrogen receptors in the liver that are responsible for hepatic output of IGF . so when taking Tren these hepatic estrogen receptors are overly sensitive and will thus stimulate more IGF production .


which leads me to my next point - ESTROGEN plays a huge role in hepatic IGF production. if your taking AI's or doing things to keep your E2 super low, then your IGF levels are also going to be super low.
also why when guys run a SARMs only cycle (with no test or AAS in there) their IGF levels plummet, because SARMs are not methylated (like oral AAS are which seems to raise iGF) and they also do not aromatize into estrogen, and they are suppressive to natty test, so estrogen levels go down (and thus so do IGF levels)


and one more note - muscle cells are NOT only dependent on IGF thats produced in the liver and shows up on blood work,, muscle cells when stimulated with heavy training have the ability to produce their own inter cellular IGF..
so just because blood serum levels of IGF are low, does not mean that the muscle cells don't necessarily have sufficient IGF because they can just produce their own