I've searched over and over trying to find any thread with an answer or with this question at least being brought up..

If you're running an AI regularly through out a cycle, is there potential chance of an estrogen rebound from missing/going a certain period without your normal dosage?

To put my question in better perspective, when/if I start a cycle I plan to run Aromasin @ 12.5mg twice a day from day one. After manipulating your estrogen for so long could I come across any negative side effects from missing x amount of days? Obviously I would have plenty on hand to see it through the whole cycle, but you always need to be ready for the unexpected.