Done it twice..
Seems to kick in about 12 hours after i took it both times..
and like 24-30 hours later it really kicks in nicely, and it stays nice for another day or so..

so in my case.. It seems to effect me for about 4-5 days.. with the effects being the best around day 3/4 .. day 2 is nice too.

I've been taking it about an hour before i go out on weekends, but next weekend i'll try n take it a day before i go out, see if it works better.

thats my experience thus far.
Potency the second time is just as nice as the first...

annoyances really flushed in the first 8 hours of taking it. In those hours i really dont feel the effects of it either..
so another reason to take it a whole day earlier next time, get the flushed feeling out of the way.