SARMS not SERMS

[testfeind123]

Idk if anyone noticed but there seems to be a lot of pct threads in here but this is suppose to be for threads about Selective Androgen Receptor Modulators not Selective Estrogen Receptor Modulators there is a difference brothers

[testfeind123]

Bump jus as a reminder

[Bonaparte]

Correct. Unfortunately, most of the guys who start threads in this section will never understand the difference between an ER and AR.

[West Coast Winner]

Hahaha bump!

[att123]

what is the diff of sarm vs serm. i get the abreviated break down of what it stands for but the diff??

[Simon1972]

Selective Estrogen Receptor Modulator or SERMs Compounds that bind with estrogen receptors and exhibit estrogen action in some tissues and anti-estrogen action in other tissues. The ideal SERM would deliver all the benefits of estrogen without the adverse effects. ex: Clomiphene Citrate (Marketed as Clomid or Serophene). Tamoxifen (Marketed as Nolvadex ).

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.
http://forums.steroid.com/showthread...highlight=sarm

Selective Estrogen Receptor Modulator (SERM) Compounds that bind with estrogen receptors and exhibit estrogen action in some tissues and anti-estrogen action in other tissues. The ideal SERM would deliver all the benefits of estrogen without the adverse effects. ex: Clomiphene Citrate (Marketed as Clomid or Serophene). Tamoxifen (Marketed as Nolvadex).

Aromatise Inhibitor (AI) Aromatase inhibitors exhibit a very different mechanism of action than SERM’s. Aromatase inhibitors prevent the conversion of androgens into estrogen in fat, muscle, breast, and brain. ex: Anastrazole (brand name Arimidex ). FEMARA (letrozole tablets).

NOTE: Clomid and Nolvadex are both anti-estrogens belonging to the same group of triphenylethylene compounds. They are structurally related and specifically classified as selective estrogen receptor modulators (SERMs) with mixed agonistic and antagonistic properties. This means that in certain tissues they can block the effects of estrogen, by altering the binding capacity of the receptor, while in others they can act as actual estrogens, activating the receptor. In men, both of these drugs act as anti-estrogens in their capacity to oppose the negative feedback of estrogens on the hypothalamus and stimulate the heightened release of GnRH (Gonadotropin Releasing Hormone). LH output by the pituitary will be increased as a result, which in turn can increase the level of testosterone by the testes.

Although these two are related anti-estrogens, they appear to act very differently at different sites of action. Nolvadex seems to be strongly anti-estrogenic at both the hypothalamus and pituitary, which is in contrast to Clomid, which although a strong anti-estrogen at the hypothalamus, seems to exhibit weak estrogenic activity at the pituitary.

[att123]

Awesome Simon! Thanks

[KINGKONG]

Thought we we had somme break through info huh?