HGH,AAS - increase the number of muscle cells?

[vitor]

HGH can also inhibit Myoatatin up to 40% according to valid studies, which might have an active role in muscle grow, it certanly has in animals.

bump, for more opinions on hgh and hyperplasmia...

[MuscleScience]

HGH can also inhibit Myoatatin up to 40% according to valid studies, which might have an active role in muscle grow, it certanly has in animals.

Good point!!!!

[IntenseAthlete]

Good point!!!!

elaborate

[MuscleScience]

elaborate

Believe it or not the human body is not designed to hold excessive amount of muscle mass for a couple of reasons evolutionarly speaking. One reason is that it takes a lot of energy and nutrients to build muscle. The second is that it takes a lot of energy to just maintain muscle mass. We have evolved very powerful inhibitory mechanisms to control muscle growth. Steroids, IGF and HGH seem to some extent inhibit the myostatin control mechanism. Myostatin is a protein that is expressed especially under fasting conditions that inhibit muscle mass development. If your starving you don't want the nutrients that you are comsuming to go to building muscle. Instead you want it to go to other more essiential parts of the body. Other control mechanisms include cortisol, which is a more systemic catabolic hormone that we all hear about.

[vitor]

Good point!!!!

There has been speculation if HGH could cause hyperplasmia thrue inhibiting the Myostatin aswell, something like this process:

If you neutralize myostatin, then the satellite cells would proliferate much longer, substansially increasing the number of myoblast produced. These myoblast would mature into myocits, then into myotubes, and ultimately into new muscle cells.

What do you think?

[MuscleScience]

There has been speculation if HGH could cause hyperplasmia thrue inhibiting the Myostatin aswell, something like this process:

If you neutralize myostatin, then the satellite cells would proliferate much longer, substansially increasing the number of myoblast produced. These myoblast would mature into myocits, then into myotubes, and ultimately into new muscle cells.

What do you think?

I was hoping no one would bring satellite cells up. LOL

If there is a mechanism this is as good as any. I personally feel that if indeed it does occur that this is the most likely way.

I have read a few papers about satellite cell being induced to differentiate into new muscle cells. The problem with it is that the literature is real hardcore physiology and they are long and boring to read so I don't like looking at it much.

But now my interest is sparked, I will probably go through some literature over xmas break when I have time. The journal of applied physiology is were I have seen most of this stuff. If you have ever read one of those papers then you know what I am talking about Victor. LOL

[vitor]

But now my interest is sparked, I will probably go through some literature over xmas break when I have time. The journal of applied physiology is were I have seen most of this stuff. If you have ever read one of those papers then you know what I am talking about Victor. LOL

Yeah I have gone thrue one of those papers. But english is my 2 language, so the literature became to heavy for me to read lol, I didnt understand it properly enough to explain this in detail

[MuscleScience]

Yeah I have gone thrue one of those papers. But english is my 2 language, so the literature became to heavy for me to read lol, I didnt understand it properly enough to explain this in detail

It seemed like you got it well enough to me.

[IntenseAthlete]

I was hoping no one would bring satellite cells up. LOL

If there is a mechanism this is as good as any. I personally feel that if indeed it does occur that this is the most likely way.

I have read a few papers about satellite cell being induced to differentiate into new muscle cells. The problem with it is that the literature is real hardcore physiology and they are long and boring to read so I don't like looking at it much.

But now my interest is sparked, I will probably go through some literature over xmas break when I have time. The journal of applied physiology is were I have seen most of this stuff. If you have ever read one of those papers then you know what I am talking about Victor. LOL

So this satellite cell/myoblast process is what studies say is hyperplasia?or where it could be happening?Or if it is possible this is the most likely way if it could be explained

[MuscleScience]

So this satellite cell/myoblast process is what studies say is hyperplasia?or where it could be happening?Or if it is possible this is the most likely way if it could be explained

Yep, that is were most of the interest is centered right now in much of the research. Keep in mind though its not a huge factor in muscle size increase, hypertrophy is still the main and most important way muscles grow in size.

[IntenseAthlete]

Yep, that is were most of the interest is centered right now in much of the research. Keep in mind though its not a huge factor in muscle size increase, hypertrophy is still the main and most important way muscles grow in size.

So size aside,for an athlete to dope in the off season hoping to acheive things he can recruite later when he is clean or during the season.Is this a more viable egde.In theory?Holding on to 1 or 2% of total performance improvement is podium to not even making the qualifing time.From where Im at its power not weight gain anyway.