Nolvadex during the whole cycle. Enough?

[Merc..]

Have read this thread ??

http://forums.steroid.com/showthread...light=estrogen

Nolva lowers IGF ( and can effect your gains )...

Merc.

[ChuckLee]

Have read this thread ??

http://forums.steroid.com/showthread...light=estrogen

Nolva lowers IGF ( and can effect your gains )...

Merc.

oops

[Merc..]

oops

LOL.CL. No no .. I was just saying ...

[manwitplans]

Have read this thread ??

http://forums.steroid.com/showthread...light=estrogen

Nolva lowers IGF ( and can effect your gains )...

Merc.

Yep I actually have.
But what do you recommend when I have gyno from puberty?
Nolvadex will help with keeping the estrogen higher then arimidex throughout, so that's better then, for the gains, right?

Would it be wize for a guys like me to start a cycle of say perhaps 500mg test and run it till I get gyno symptoms? I don't think so, since i've already got it, but share your honest opinion on which approach you would do if you were in my shoes.

[Merc..]

Yep I actually have.
But what do you recommend when I have gyno from puberty?
Nolvadex will help with keeping the estrogen higher then arimidex throughout, so that's better then, for the gains, right?

Would it be wize for a guys like me to start a cycle of say perhaps 500mg test and run it till I get gyno symptoms? I don't think so, since i've already got it, but share your honest opinion on which approach you would do if you were in my shoes.

Yes, nolva binds the receptor ( but it doesn't lower total estrogen levels )like a AI does ...

Like I said nolva lowers IGF-1 so it can reduce gains as well.. Here is a study showing that nolva has a effect on IGF ( there are tons of studies on this)..

Tamoxifen reduces serum insulin-like growth factor I (IGF-I).Pollak MN, Huynh HT, Lefebvre SP.
McGill University, Montreal, Quebec, Canada.

Antiestrogens are widely used in the management of hormonally responsive breast cancer in both adjuvant and palliative settings, and are currently being evaluated as chemopreventive agents. The classical mechanism of action of these drugs involves inhibition of estrogen-stimulated neoplastic cell proliferation by blockade of estrogen receptors present on breast cancer cells. This paper reviews recent clinical and laboratory data that suggest that the commonly used antiestrogen tamoxifen also acts to reduce serum IGF-I levels. Estrogens appear to play a permissive role in growth hormone (GH) release by the pituitary gland and GH is known to stimulate IGF-I expression by hepatocytes. It is therefore possible that blockade of estrogen receptors in the hypothalamic-pituitary axis by tamoxifen interferes with GH release, leading to reduced hepatic IGF-I expression. In view of results suggesting that IGF-I is a more potent mitogen than estradiol for breast cancer cells and data demonstrating a positive correlation between estrogen receptor level and IGF-I receptor level of breast cancer cells, the IGF-I lowering effect of tamoxifen may contribute to the cytostatic activity of the drug. The interrelationships between steroid hormone physiology and IGF-I physiology may have relevance to a variety of commonly used treatments for hormonally responsive cancers.

PMID: 1421427 [PubMed - indexed for MEDLINE]


How bad is your gyno ?? You could look into using nolva .. I was just saying that it can also effect gains ..

Have you considered trying to treat your gyno ? ( using a non surgical method ) ??


Merc.