It seems like the by product of the drug going into the intestinal track is causing colitis, and other nasty Lower GI issues.
I think that if they made it in an injectable form, it may solve the issue.
But, that would be exspensive and what not.
http://www.injuryboard.com/national-...oogleid=246086
http://www.drug-injury.com/druginjur...-by-roche.html
http://accutane.poweradvocates.com/
Best
T