1. If that is the case then I suspect that you were either not having enough T4 or too much T4 as both hypothyroidism and hyperthyroidism can make you feel tired.
2. People suffering from both hypothyroidism and hyperthyroidism experience water retention problems, maybe your wife does not need 50mcg of T4 with 1.8iu's of rHGH or she may need more? Has she had her bloods done whilst taking this amount of rHGH?