Anavar drying out joints like Anavar?? HUH?

[Bonaparte]

http://www.mesomorphosis.com/article...our-joints.htm

Check out the info and sources if you like.

Winstrol is indeed 5 alpha reduced, as mentioned. However, it still acts as a progesterone antagonist, effectively mimicking the effect free DHT has in the body. The method is different, but the result is the same; decreased progesterone. I was simply never clear on the method, but have since researched further. My apologies for the unintentional dissemination of misinformation.

1) First off, Anthony Roberts is the biggest retard in the world of AAS and has 0 credibility. There is a sticky on this site explaining why.

2) That article is 5 years old, so a lot of things have changed since then (due to more recent studies and findings).

Other than that, yes, I believe that Winstrol does compete for the progesterone receptor, and that this might partially explain why it dries out the joints so bad. However, it doesn't actually lower progesterone, just compete with it at the receptor. And this is still largely speculation and theory based on this pub-med article:
http://www.ncbi.nlm.nih.gov/pubmed/8079819

You also have to take into account that Winny is 5a-reduced and binds tightly at the AR, so it antagonizes estrogen effectively, which will dry out your joints by itself to a degree.

[TKO Performance]

1) First off, Anthony Roberts is the biggest retard in the world of AAS and has 0 credibility. There is a sticky on this site explaining why.

2) That article is 5 years old, so a lot of things have changed since then (due to more recent studies and findings).

Other than that, yes, I believe that Winstrol does compete for the progesterone receptor, and that this might partially explain why it dries out the joints so bad. However, it doesn't actually lower progesterone, just compete with it at the receptor. And this is still largely speculation and theory based on this pub-med article:
http://www.ncbi.nlm.nih.gov/pubmed/8079819

You also have to take into account that Winny is 5a-reduced and binds tightly at the AR, so it antagonizes estrogen effectively, which will dry out your joints by itself to a degree.

Yes, I know no one likes the author, but you have to look deeper than that. I actually took the time to research his sources, and though the author may be a parrot for them; the source material is legitimate. This is evidenced by your link, which if I'm reading right dates back to 1994. It's pretty clear that progesterone modulates actual DNA synthesis relating to collagen synthesis. Until there is some groundbreaking study that shows otherwise I think we can safely assume that modern science is in agreement on that point.

The antagonistic effect on estrogen is also another reason why you can experience joint issues with Winstrol. From what I've read it seems that this effect is also likely progesterone based, but there is not 100% certainty on that at this time.