2 kinds of gyno, progest & oest...

[Dr.Roidz]

Would an AI be effective against ligands that directly activate PGR?

Since your bored and all

[Swifto]

Would an AI be effective against ligands that directly activate PGR?

Since your bored and all

No but Tamoxifen would when treating PgR related gyno.

My point is controlling estrogen, helps to control progesterone. But you know that.

You think compounds such as, RU-486 (mifepristone) are needed with compounds that are full agonists of the PgR then?

If you wish to add anything, do so...

[Dr.Roidz]

No but Tamoxifen would when treating PgR related gyno.

My point is controlling estrogen, helps to control progesterone. But you know that.

absolutely

You think compounds such as, RU-486 (mifepristone) are needed with compounds that are full agonists of the PgR then?

For those that are unlucky enough to develop gyno as a result of PGR activation even in the absence of elevated estrogen levels.
When PGR is activated mammary epithelial cells act paracrinely to induce more neighboring cell branching. So I would say a PGR antagonist would be needed.

If you wish to add anything, do so...

Not really just picking your brain since you are bored and seem to have a lot of knowledge in the area.

[Swifto]

Not really just picking your brain since you are bored and seem to have a lot of knowledge in the area.

In the absence, yes. Buts thats extremely rare.

What's going to increase PgR levels in the absence of estrogen though?

Tren alone? With good cycle planning, the example(s) your about to give shouldnt exist IMHO. Unless I'm missing something.