Beta Blockers on cycle?

[jimmyinkedup]

Pretty sure beta blockers don't do that...but PDE5 inhibitors do (Viagra, Cialis, etc)

Third genration beta blockers do increase NO and result in vasodialation.
Also there are a couple that are b and a1 antagonists - these do result in vaosdialation as well.

[Bonaparte]

Third genration beta blockers do increase NO and result in vasodialation.
Also there are a couple that are b and a1 antagonists - these do result in vaosdialation as well.

Good stuff. I can see how B1 inhibition would relax blood vessels, since B1 receptors are responsible for vasoconstriction.
Through what mechanism do they increase NO?

[jimmyinkedup]

Good stuff. I can see how B1 inhibition would relax blood vessels, since B1 receptors are responsible for vasoconstriction.
Through what mechanism do they increase NO?

2 fold IIRC -
1-rise in calcium independant NO synthase
2-NO liberation from endothelial cells as a result of stimulation of p2y purinoceptor