First time contemplating DNP

[gonzo6183]

Hey im lookinf for a detailed giude to first time use on DNP, have read the profile but looking for a good thread and have been unable to search "DNP" this is just gathering knowledge on the compound at this stage.

Cheers

Gonzo

[Crest]

There used to be a good sticky from a bloke called tai boxa. Looks like it's been deleted. Not sure if he still posts at all????

[Times Roman]

We've had a variety of discussions regarding this "dietary" product. The conclusion is usually the same.... something to avoid due to the toxicological response. Straight up, this stuff is poison!

http://en.wikipedia.org/wiki/2,4-Dinitrophenol

2,4-Dinitrophenol (DNP), C6H4N2O5, is a cellular metabolic poison. It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a rapid consumption of energy without generation of ATP.

Dinitrophenols as a class of compounds, of which there are six members, do not occur naturally but are all manufactured compounds.
Chemical properties

2,4-Dinitrophenol is a yellow, crystalline solid that has a sweet, musty odor. It sublimes when carefully heated and is volatile with steam. It is soluble in ethyl acetate, acetone, chloroform, pyridine, carbon tetrachloride, toluene, alcohol, benzene, and aqueous alkaline solutions.[1] Its crystalline sodium salts are also soluble in water. It forms explosive salts with alkalies and ammonia, and emits toxic fumes of nitrogen oxides when heated to decomposition.[2] It is incompatible with heavy metals and their compounds.

[edit] Uses

Commercial DNP is primarily used for scientific research and in manufacturing. It has been used at times to make dyes, other organic chemicals, and wood preservatives. It has also been used to make photographic developer, explosives, and pesticides.

[edit] Pharmacological action

In living cells, DNP acts as a proton ionophore, an agent that can shuttle protons (hydrogen ions) across biological membranes. It defeats the proton gradient across mitochondria and chloroplast membranes, collapsing the proton motive force that the cell uses to produce most of its ATP chemical energy. Instead of producing ATP, the energy of the proton gradient is lost as heat.

DNP is often used in biochemistry research to help explore the bioenergetics of chemiosmotic and other membrane transport processes.

[edit] Dieting aid

DNP was used extensively in diet pills from 1933 to 1938 after Cutting and Tainter at Stanford University made their first report on the drug's ability to greatly increase metabolic rate.[3][4] After only its first year on the market Tainter estimated that probably at least 100,000 persons had been treated with DNP in the United States, in addition to many others abroad.[5] DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat. The inefficiency is proportional to the dose of DNP that's taken. As the dose increases and energy production is made more inefficient, metabolic rate increases (and more fat is burned) in order to compensate for the inefficiency and meet energy demands. DNP is probably the best known agent for uncoupling oxidative phosphorylation. The production or "phosphorylation" of ATP by ATP synthase gets disconnected or "uncoupled" from oxidation. Interestingly, the factor that limits ever-increasing doses of DNP is not a lack of ATP energy production, but rather an excessive rise in body temperature due to the heat produced during uncoupling. Accordingly, DNP overdose will cause fatal hyperthermia. In light of this, it's advised that the dose be slowly titrated according to personal tolerance, which varies greatly.[6] Case reports have shown that an acute administration of 20–50 mg/kg in humans can be lethal.[7] Concerns about dangerous side-effects and rapidly developing cataracts resulted in DNP being discontinued in the United States by the end of 1938. DNP, however, continues to be used by some bodybuilders and athletes to rapidly lose body fat. Fatal overdoses are rare, but are still reported on occasion. These include cases of accidental exposure,[8] suicide,[7][9][10] and excessive intentional exposure.[9][11][12]

There are limited and conflicting data on the pharmacokinetics of DNP in humans. The EPA states that "Data on the elimination kinetics of the dinitrophenols or their metabolic products in humans were not found."[13] The ATSDR's Toxicological Profile for Dinitrophenols also states that "No studies were located regarding distribution in humans after oral exposure to 2,4-DNP. Limited information is available regarding distribution in animals after oral exposure to 2,4-DNP." However, they do state that "Elimination from the body appears to be rapid, except possibly in cases of compromised liver function."[14] This coincides with a review in the NEJM on the biological actions of dinitrophenol, which stated that "Judging from the metabolic response, DNP appears to be eliminated entirely in three or four days; in the presence of liver or kidney damage it is possible that the drug will be retained over a longer period."[15] Oddly, more recent papers give an array of possible half-lives, ranging from 3 hours,[16] to 5–14 days.[7] Other recent papers maintain that the half-life in humans is unknown.[9]

Although further investigation is needed, one case report notes that dinitrophenol-induced hyperthermia has been successfully resolved with dantrolene administration.[17] "Dinitrophenol uncouples oxidative phosphorylation, causes release of calcium from mitochondrial stores and prevents calcium re-uptake. This leads to free intracellular calcium and causes muscle contraction and hyperthermia. Dantrolene inhibits calcium release from the sarcoplasmic reticulum which reduces intracellular calcium. The resulting muscle relaxation allows heat dissipation. There is little risk to dantrolene administration. Since dantrolene may be effective in reducing hyperthermia caused by agents that inhibit oxidative phosphorylation, early administration may improve outcome."[18]

While DNP itself is considered by many to be too risky for human use, its mechanism of action remains under investigation as a potential approach for treating obesity.[19] Currently, research is being conducted on uncoupling proteins naturally found in humans.

[edit] Environmental toxicity

DNP is considered an important environmental contaminant by the United States Environmental Protection Agency. It has been found in 61 of 1400 priority sites that need clean-up of industrial waste. It can enter the air from automobile exhaust, burning of certain industrial substances, and from reaction of nitrogen in air with other atmospheric chemicals. The major site of degradation is the soil, where microorganisms metabolize it.

However, the effects of DNP on anaerobic micro-organisms are still largely undetermined. Some studies suggest that there is anaerobic toxicity due to a reduced methane production.

[vBRAH]

I've run DNP a few times, I'm a fan of it to be honest. Just need to make sure you do your research, keep fluids up, eat right, train right, stay healthy and remember it isn't a magic pill. Google "DNP for dummies" or "How not to fcuk up on DNP" for a few good reads - its not for everyone and as with everything if you abuse it you're in a whole heap of trouble.

[slimshady01]

I get scared just seeing the word DNP.

[jimmyinkedup]

There seems to be a resurgence of this on several boards now. Its rather alarming. Somehow its becoming almost "cool" to use it. Young kids on boards trying to run the craziest cycles and using thing like dnp emphasizing how safe it is based on BS like studies it doesnt cause cancer while ingnoring the simoe fact that its hyperthermic effects could cause great harm even death. Thank god it isnt likethat here. Also OP im not saying thats the case with you by any means (the being cool thing)

At what point do we get back to simple discipline and hard work? Why is this "short cut" even necessary? When I see the recommendations of those that run it - with the supplementation scheudle etc to offset all these effects i say to myself wtf? How about simply burning more calories than you eat? Not many could tell me using this isnt just being lazy....lkets be hionest those posting in these boards arent 5 days out from the olympia with several extra pounds to lose which could mean the diff in large sums of maoney. We dont pay our bills doing this. How the hell is the use oif this susbstance justified as worth it? I hear many sayt oh its just an aid like AAS I say BS - AAS take us above our genetic potential. ANYONE can burn fat if the burn more calories than they eat - period end of story. IMO its time to take a step back - honestly assess where we are within this sport - and make more prudent , long term decisions and get back to the discipline , desire and hard work that is the foundation of this sport as opposed to using something like DNP.

[Crest]

Good post! Let face it we can lower the risks with AAS but lets face it. They aren't doing you any good. Why poison yourself more than you have to?

[dece870717]

This page has some good information http://www.steroid.com/The-Whole-Truth-About-DNP.php .

I've personally ran DNP multiple times and it definitely is an amazingly fast fat burner. Side effects just like with anything are dose dependent, high doses make you feel like crap, while low doses are quite bearable to almost not very noticeable. Now high doses with high carb intake is the absolute WORST! High doses with very low to almost no carb is much more bearable but comes with a little extra lethargy and can make you go hypo if doing something too physically intensive.

[m16a2]

I've used DNP for fat burning cycles numerous times over the last 6 years. There is so much information available that it can be overwhelming. In the end, I would say that if you have good discipline, self control, and patience, then DNP *might be something that would work for you. After trying a variety of combinations, the best results I've seen are at a low dose for 3-4 weeks. You will barely feel the heat so people tend to increase the dose (this is where discipline comes in). Next, if you weigh yourself daily, you won't notice any changes for at least 7-10 days (patience). It is easy to cheat on your diet while on DNP. But if you want to see the fat drop instead of the realizing a net-zero effect from an increased caloric intake, then you need to have self control. Then, you will notice over the next 14 days, the weight slowly drops. I've consistently gotten 10-12 lbs of fat loss with my method with almost no muscle loss.

In summary, the most effective method is probably the safest with the lowest dose. You just need to be mentally prepared to run the cycle properly. I've documented my last 4 cycles, spanning 4 years, so my results are statistically reliable and consistent.

[AnabolicDoc]

If you don't mind, I wanted to know what dose you took, and what your regimen was regarding AAS, supplements, and any other ancillaries when running DNP.

I tried sending you a PM, but I don't have such privileges yet.

Thank you in advance.

[samatash]

I actually ran DNP for a whole month recently. 200mg per day, taken in the morning upon waking up.

With such a low dose I experienced minimal sides at worst but benefited greatly from its fat-burning effects. I have never calculated my body fat % so I can't give you results based on it, but to give you an idea I dropped my waist size from a tight 34 to a 28-30, lost no strength at all, absolutely no muscle loss.

I think the ONLY side effects I experienced were dry mouth after about 2 weeks in and also yellow-colored semen, but these quickly went away as soon as I stopped with my cut.

DNP works very well with EC stack, which I took it with. I recommend Bronkaid for your E.

[Perseverance1]

I actually ran DNP for a whole month recently. 200mg per day, taken in the morning upon waking up.

With such a low dose I experienced minimal sides at worst but benefited greatly from its fat-burning effects. I have never calculated my body fat % so I can't give you results based on it, but to give you an idea I dropped my waist size from a tight 34 to a 28-30, lost no strength at all, absolutely no muscle loss.

I think the ONLY side effects I experienced were dry mouth after about 2 weeks in and also yellow-colored semen, but these quickly went away as soon as I stopped with my cut.

DNP works very well with EC stack, which I took it with. I recommend Bronkaid for your E.

Were you on cycle when you took DNP, or off?

[AnabolicDoc]

I actually ran DNP for a whole month recently. 200mg per day, taken in the morning upon waking up.

With such a low dose I experienced minimal sides at worst but benefited greatly from its fat-burning effects. I have never calculated my body fat % so I can't give you results based on it, but to give you an idea I dropped my waist size from a tight 34 to a 28-30, lost no strength at all, absolutely no muscle loss.

I think the ONLY side effects I experienced were dry mouth after about 2 weeks in and also yellow-colored semen, but these quickly went away as soon as I stopped with my cut.

DNP works very well with EC stack, which I took it with. I recommend Bronkaid for your E.

Thank you very much for sharing your experience. I really appreciate it. Your results sound incredible. How long did it take for u to see those results? (I see that you referenced 2 weeks, I'm just not sure if that's how long you took the DNP for.)

I agree Bronkaid is great. I have also started to see Primatene on the shelves again, after a brief hiatus.

I was considering a dose of 50mg per day, or rather 100mg eod (only bc I have not yet come across tabs of a dosage lower than 100mg). I'd rather err on the less hazardous side and have more modest results. I must admit that I am definitely scared from all the horror stories of DNP, even if they were at higher doses.

If anyone has experienced with doses of less than 200mg per day and is willing to share, it would be very much appreciated.

On other forms when the topic of DNP comes up some ppl can get very nasty and overheated (no pun intended). I appreciate the civility of this forum and its definitely one of the main reasons I joined (that and I have always loved the educational material at steroid.com. Thank you.

[samatash]

Were you on cycle when you took DNP, or off?

I have not taken any AAS yet. DNP is touted for its muscle-sparing qualities, btw. I think this holds all the more true considering I took a very moderate dose.

[AnabolicDoc]

I actually ran DNP for a whole month recently. 200mg per day, taken in the morning upon waking up.

With such a low dose I experienced minimal sides at worst but benefited greatly from its fat-burning effects. I have never calculated my body fat % so I can't give you results based on it, but to give you an idea I dropped my waist size from a tight 34 to a 28-30, lost no strength at all, absolutely no muscle loss.

I think the ONLY side effects I experienced were dry mouth after about 2 weeks in and also yellow-colored semen, but these quickly went away as soon as I stopped with my cut.

DNP works very well with EC stack, which I took it with. I recommend Bronkaid for your E.

Thank you very much for sharing your experience.

I was wondering if anyone has tried doses of less than 200mg per day and what kind of results they had. I haven't come across capsules less than 100mg per day, so I was thinking either 100mg ed or eod.

[Perseverance1]

Thank you very much for sharing your experience.

I was wondering if anyone has tried doses of less than 200mg per day and what kind of results they had. I haven't come across capsules less than 100mg per day, so I was thinking either 100mg ed or eod.

Based on my limited knowledge of this poison, I think 400mg/day is the "normal" amount for short cycles...but I would suggest 200mg a day over a little longer period of time as this stuff is no joke...actually I would recommend staying away from it...but to each his own I suppose.

[AnabolicDoc]

Based on my limited knowledge of this poison, I think 400mg/day is the "normal" amount for short cycles...but I would suggest 200mg a day over a little longer period of time as this stuff is no joke...actually I would recommend staying away from it...but to each his own I suppose.

I understand where you're coming from. Ideally we'd all have the time, discipline, and genetic predisposition to lose weight the old fashioned way. And I mean that sincerely (I do my best although I'm sure I could be doing much better). But many ppl feel that way about AAS use as well. And while I don't agree with AAS naysayers, I don't completely agree with DNP naysayers.

While I do agree that DNP is a poison and AAS are not classified as poisons, they both have the potential to offer great benefits if used properly and great harm if misused. The biggest problem with DNP use seems to be that ppl think more is always better. This is clearly not the case and many have suffered as a result. But there are many institutions that are still researching DNP use for its role in weight loss. I've seen studies that show clinical effectiveness at 30mg per day and I'd like to try a dose close to that (like I said in my earlier post i was thinking of 100mg eod).

But if possible I'd first like to hear from anyone who may have tried a lower dose so that I can learn from their experiences. I have searched the forums for dinitrophenol, and I will continue to do so but it is time consuming to sift through all the threads. Many of the threads are just ppl arguing about its toxicity and attacking one another for considering its use and so forth. That's not to say that I haven't come across plenty of useful information and experiences as well. I really appreciate the civility that has been shown on this thread and I hope it continues.

Thank you to all this who contribute. It is very much appreciated. And if I hijacked this thread, I apologize but there were no posts in over a year. So I hope I have not inconvenienced anyone.

[Perseverance1]

I understand where you're coming from. Ideally we'd all have the time, discipline, and genetic predisposition to lose weight the old fashioned way. And I mean that sincerely (I do my best although I'm sure I could be doing much better). But many ppl feel that way about AAS use as well. And while I don't agree with AAS naysayers, I don't completely agree with DNP naysayers.

While I do agree that DNP is a poison and AAS are not classified as poisons, they both have the potential to offer great benefits if used properly and great harm if misused. The biggest problem with DNP use seems to be that ppl think more is always better. This is clearly not the case and many have suffered as a result. But there are many institutions that are still researching DNP use for its role in weight loss. I've seen studies that show clinical effectiveness at 30mg per day and I'd like to try a dose close to that (like I said in my earlier post i was thinking of 100mg eod).

But if possible I'd first like to hear from anyone who may have tried a lower dose so that I can learn from their experiences. I have searched the forums for dinitrophenol, and I will continue to do so but it is time consuming to sift through all the threads. Many of the threads are just ppl arguing about its toxicity and attacking one another for considering its use and so forth. That's not to say that I haven't come across plenty of useful information and experiences as well. I really appreciate the civility that has been shown on this thread and I hope it continues.

Thank you to all this who contribute. It is very much appreciated. And if I hijacked this thread, I apologize but there were no posts in over a year. So I hope I have not inconvenienced anyone.

It sounds like you're at least going about this the "right" way. Can't fault you for that. Best of luck to you man, let us know how it turned out if you do end up using it.

[Metalject]

I agree that DNP is pure poison. I think it's one of the few classified performance enhancing drugs that's insane to use. Even if you have a positive experience the first or second time you use it, even if you use the same amount the next time does not mean the experience will be as good...there are too many factors of consideration.

All that said, I have to disagree with comments about it not being a magic pill because it's about as close to magic as anything we can get. THis stuff will destroy fat cells, as in literally destroy them. Normally when you're losing weight you're only shrinking fat cells, but they're still there in the end.

Anyway, seen a lot of guys use DNP over the years. It's always been popular to one degree or another, at least in discussion. Of those guys, seen some success and seen some disasters. Knew one guy who used it for several years no problems and then his last run he ended up hospitalized and nearly died...miracle that he didn't. In my opinion, there are only two legitimate ways to lose weight, dieting and that can be with or without PED's or surgery, that's it. Personally I'll take a tuck or lyopsuction all day long over DNP.

[t-gunz]

used it twice will never use it again. sides were horrible, sweat is yellow sperm is yellow, hard time exercising

fat loss itsnt that great. if you got fat to loose just diet and train. simple and effective and SAFE this is from experience

[Perseverance1]

used it twice will never use it again. sides were horrible, sweat is yellow sperm is yellow, hard time exercising

fat loss itsnt that great. if you got fat to loose just diet and train. simple and effective and SAFE this is from experience

Can you elaborate a bit on your experience? How long did you use it, what dose, what were the results?

[t-gunz]

Can you elaborate a bit on your experience? How long did you use it, what dose, what were the results?

sure

i used it for 4 weeks both. and i started at 100mg and worked up to about 500mg for 3 days as i couldnt take it anymore. then tapered down and sat on about 300mg as i found it comfortable.

i did tow type of diets one was a lot of carbs about 350g a day and one was keto. i noticed no real difference. fat loss to me was minimal. i found i got better results eating clean and weights with cardio


i am no means saying not to use it just letting you know before you do it so you can see my point of view and anothers and make your conculsion

hope that helped a bit

[AnabolicDoc]

That does help, thank u.

I'm shocked that at roughly 300 per day you were unsatisfied with the results.