Thank you for your answer Machdiesel. When we talk about long term, I believe it means years. Actually I would not do it that long. With short cycles and break periods I would not worried about heart issues at all, but actually I am not an expert

I read in one of the threads here that someone had horribly shaky hands and he felt like an alcoholic. Is it common effect?
So, do you recommend to go up the highest mcg I can cope with, lets say within a week and keep that dose until the end of my planned interval? What is the reasonable BF reduction within a 30 period? How long should be one safe cycle?