Quote Originally Posted by Bonaparte View Post
Short answer: no. High doses of insulin (and concurrent use of shitloads of carbs) will contribute to insulin resistance (bear in mind that AAS decrease insulin resistance, so they largely balance each other out), but there is no reason why it would negatively affect the pancreas.
And it's not like one's pancreas stops producing insulin just because they are using insulin for BB'ing purposes. We only take one or two doses daily of fast-acting insulin, so there is still plenty of opportunity for the pancreas to secrete insulin.